The Distribution of Potassium Isotopes in Biological Material

Mullins, L. J.; Zerahn, K.

doi:10.1016/s0021-9258(18)57380-4

Cited by 17 publications

(1 citation statement)

References 20 publications

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“… 78 being the only published contemporary dataset for comparison (see also the early historical work of Mullins et al. 90 and preprint of Higgins et al. 79 ).…”

Section: Discussionmentioning

confidence: 99%

Exploring the K isotope composition of Göttingen minipig brain regions, and implications for Alzheimer's disease

et al. 2022

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Natural stable metal isotopes have shown utility in differentiation between healthy and diseased brain states (e.g. Alzheimer's disease, AD). While the AD brain accumulates some metals, it purges others, namely K (accompanied by increased serum K, suggesting brain-blood transferal). Here, K isotope compositions of Göttingen minipig brain regions for two AD models at mid-life are reported. Results indicate heavy K isotope enrichment where amyloid beta (Aβ) accumulation is observed, and this enrichment correlates with relative K depletion. These results suggest preferential efflux of isotopically light K + from the brain, a linkage between brain K concentrations and isotope compositions, and linkage to Aβ (previously shown to purge cellular brain K+). Brain K isotope compositions differ from that for serum and brain K is much more abundant than in serum, suggesting that changes in brain K may transfer a measurable K isotope excursion to serum, thereby generating an early AD biomarker.

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“… 78 being the only published contemporary dataset for comparison (see also the early historical work of Mullins et al. 90 and preprint of Higgins et al. 79 ).…”

Section: Discussionmentioning

confidence: 99%