The Distribution of Some Enzyme Group Systems Among Marathis and Gujaratis in Bombay

Blake, N. M.; Kirk, R. L.; Baxi, A.J.

doi:10.1159/000152337

Cited by 28 publications

(9 citation statements)

References 2 publications

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“…Among the Gujarati and Marathi-speaking persons sampled in Bombay, Blake et al [1970] found AK2 frequencies of 0.1115 and 0.0909, respectively. The Parsis have a slightly lower AK2 frequency of 0.0670 and in the small series of Iranis the frequency of AK2 is only 0.0208.…”

Section: Adenylate Kinasementioning

confidence: 91%

“…The situation in India, however, is different and a distinctive LDH variant 'Calcutta-1' is found commonly with frequencies of 1-4% [D as et al, 1970a, b;Blake et al, 1970Blake et al, , 1972, 'Calcutta-1' represents the heterozygote for an LDH A subunit mutation, and a single case of the homozygote combination LDHCa^/LD//Cal-l has been observed in a 19-year-old girl in Tamilnadu [A n a n th a k r ish n a n et al., 1970]. In the present survey LDH 'Calcutta-1' was present among the Parsis with a frequency of 3.6% but no example was observed among the 48 Iranis examined.…”

Section: Lactate Dehydrogenasementioning

confidence: 99%

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The Distribution of some Enzyme Group Systems Among Parsis and Iranis in Bombay

Undevia¹,

Blake²,

Kirk³

et al. 1972

Hum Hered

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A total of 418 Parsis and 48 Zoroastrian Iranis were sampled in Bombay and tested for 9 red cell enzyme systems controlled by genes at 11 loci. There were marked differences between Parsis and Iranis for the frequency of alleles in the acid phosphatase system, but the two populations were similar in the frequency of alleles in the phosphoglucomutase and adenylate kinase systems. No electrophoretic variation was found in either population for the peptidase A and B, ‘oxidase’, malate dehydrogenase and phosphoglucomutase (locus 2) systems, or for the lactate dehydrogenase and 6-phosphogluconate dehydrogenase systems among the small series of Iranis. Among the Parsis, however, for the 6PGD system the PGD^C allele had a frequency of 0.0263 and the PGD^R allele had a frequency of 0.0012. The Parsis also had a relatively high frequency of LDH ‘Calcutta’ variants, the frequency of the LDH^Cal-1 allele being 0.0179. The results are discussed in relation to the history of the Parsi and Irani populations in India, and compared with previous studies among Marathi and Gujarati-speaking populations in Bombay and other groups elsewhere in India.

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Section: Adenylate Kinasementioning

confidence: 91%

Section: Lactate Dehydrogenasementioning

confidence: 99%

The Distribution of some Enzyme Group Systems Among Parsis and Iranis in Bombay

Undevia¹,

Blake²,

Kirk³

et al. 1972

Hum Hered

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“…Acid Phosphatase Three alleles, PHsA, PHs& and PHsc have been reported previously in Indian populations, the commonest being PHsB and PHsA [A n a n th a k r ishnan and K ir k . 1969; Blake et al, 1970;D as el al., 1970a]. H opk in so n [1968] quotes unpublished results for 222 Indians sampled in England giving a PHsc frequency of 0.02, but investigations by our own group so far have not been able to confirm this value.…”

Section: Red Cell Enzyme Groupsmentioning

confidence: 99%

The Distribution of Serum Protein and Enzyme Group Systems among North Indians

et al. 1971

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The distribution of electrophoretic variants in 4 serum protein and 12 red cell enzyme systems has been determined among nearly 500 persons belonging to various castes in North India. No electrophoretic variants were found for transferrin or for the enzyme systems malate dehydrogenase, peptidase B, ‘oxidase’, phosphoglycerate kinase and phosphoglucomutase-locus 2. Two persons with abnormal albumins were detected, and the slower moving band has been identified provisionally as albumin Gainsville. One person with an unusual caeruloplasmin was found also, and this has been identified provisionally as Cp A_Nigera. In the haptoglobin system the overall frequency of Hp² = 0.20 is similar to that found previously in North India. The lowest Hp²frequency (0.12) was found among the Scheduled Castes. The PHs^c gene in the red cell acid phosphatase system was of low frequency (0.005) as also was the PGD^C allele (0.02) in the 6-phosphogluconate dehydrogenase system. Three phenotypes were present in the adenylate kinase system, and the AK² gene frequency of 0.09 is among the highest values reported so far. For phosphoglucomutase-locus 1, in addition to the common alleles PGM¹₁ and PGM²₁ there were several examples of the rarer PGM³₁, PGM⁶₁ and PGM⁷₁ alleles. PGM¹₁ frequencies varied from 0.63 to 0.79 in different caste groups. Seven examples of heterozygotes for the Calcutta-1 variant of lactate dehydrogenase were detected giving an overall frequency of LDH^Cal. = 0.007. A single case of Pep A 2–1 was observed in the peptidase A system. Three other enzyme systems showing electrophoretic variation had been studied previously only on Indians living in England. In the present study 3 phenotypes were present for adenosine deaminase, and the ADA² allele had a range of frequency of 0.06 to 0.20. The latter figure, for the Arora, is the highest frequency so far reported for this allele. Only rare variants were present in the phosphohexose isomerase and NADH diaphorase systems. There were 6 PHI 3–1, 1 PHI 5–1 and 1 PHI 9–1 phenotypes in a total of 490 samples tested. Half of these variants were found among the 83 persons belonging to the Scheduled Castes. In the diaphorase system there were 6 2–1 and 1 4–1 phenotypes distributed between the caste groups.

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“…Das et al (1970) first reported Calcutta-1 (Cal-1), an LDH variant at the A locus. Later it was discovered in 1-4~ of the population of India (Das et al, 1970;Blake et al, 1970;Ananthakrishnan et al, 1970). Madras-I, an LDH variant at the B locus has been found only in Madras city.…”

Section: Lactate Dehydrogenase (Ldh) Calcutta-1 and Madras-1mentioning

confidence: 99%