The distribution of transferrin, group-specific component and phosphoglucomutase-1 subtypes among the Lepchas of Darjeeling, Eastern India

Saha, N.; Mukhopadhyay, Barun; Bhattacharyya, Sudipta; Gupta, Ranjan; Basu, Amitabha

doi:10.1007/bf01910287

Cited by 6 publications

(4 citation statements)

References 35 publications

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“…This may correspond to the Mongoloid gene flow rather than be of any ecological significance as suggested by Mourant et al (1976). The distribution of Gc alleles shows a significant mongoloid gene flow into Sri Lankan populations, which corresponds to the presence of HbE in Sri Lanka (Saha, 1987). However, the observations of T] °chi in the Oraons by Kirk, Parker and Bearn (1964) could not be confirmed by our recent study.…”

Section: Resultscontrasting

confidence: 71%

Distribution of group-specific component (Gc) subtypes in several Mongoloid populations of East Asia

Saha¹

1989

Annals of Human Biology

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The distribution of group-specific component (Gc) subtypes was determined by isoelectric focussing in thin layer polyacrylamide gels of pH range 4 to 6.5, in a group of 2412 individuals from 10 Mongoloid populations of East Asia. The sample comprised 959 Chinese from different localities (Singapore, 249; Malaysia, 347; Taiwan, 246; Hong Kong, 57; Fuzhou mainland, 60), 338 Koreans, 277 Filipinos, 484 Thais, 330 Malays and 24 Indonesians. The Filipinos and Malays had lower frequencies of Gc2 (0.15 and 0.18) compared to other Mongoloid populations (0.23 to 0.32) and the Chinese (0.24 to 0.32). The frequencies of Gc1F varied from 0.39 to 0.49 in the Chinese and 0.35 to 0.52 in other Mongoloid populations. Low frequency of rarer variants was observed in most of the populations. The average frequency of Gc2 was higher in the Japanese (0.26 +/- 0.01) than in the Chinese (0.24 +/- 0.02), and in Mongoloids of East Asia (0.23 +/- 0.01) and South-East Asia (0.17 +/- 0.01). The average frequencies of Gc1F and Gc1S were similar in the Chinese and Japanese, whereas the Mongoloids of South-East Asia had a much higher frequency of Gc1F and a lower frequency of Gc1S than the Chinese, Japanese and East Asian Mongoloid populations.

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Section: Resultscontrasting

confidence: 71%

Distribution of group-specific component (Gc) subtypes in several Mongoloid populations of East Asia

Saha¹

1989

Annals of Human Biology

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“…The genetic polymorphisms of another Mongoloid population, namely, the Lepchas living in the north of West Bengal, were studied by Saha, Bhattacharyya, Mukhopadhyay, Bhattacharyya, Gupta and Basu (1987a), and Saha, Mukhopadhyay, Bhattacharyya, Gupta and Basu (1987b). Though the gene frequencies of nine polymorphic loci in two religious groups (Buddhists and Christians) of the Lepchas are found to be similar, 'minor differences in the frequencies of some alleles at the Tf, Gc, and PGM1 loci have been observed'.…”

Section: Review Of Recent Literaturementioning

confidence: 97%

Genetic relationships of the populations in eastern India

1992

Annals of Human Biology

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The genetic relationships for four sets of populations in eastern India have been studied by using gene frequency data available in the literature. The Caucasoid populations in Assam and West Bengal are genetically close but different from the Mongoloid populations in the neighbourhood. The genetic distance analysis shows that the Mongoloid populations in Assam and West Bengal cluster according to their states of residence, indicating a correlation between genetic and geographical distances.

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“…Saha (1990) observed a low frequency of HB*E (about 0.02) among Khasis of Cherrapunji district (Meghalaya) as compared to Khasis of Shillong (0.22) and reported that this may be due to relaxation of selection in the absence of malarial infection at high altitude. Saha et al (1987) have also found a low frequency of HB*E among Lepchas of Darjeeling Hills.…”

Section: Haemoglobin Ementioning

confidence: 82%

Genetics of Castes and Tribes of India: Glucose-6-Phosphate Dehydrogenase Deficiency and Abnormal Haemoglobins (HbS and HbE)

Bhasin

2006

International Journal of Human Genetics

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The discipline of Biological Anthropology (or Human Biology) incorporates study of biology and environmental factors, as well as the forces of micro-evolution leading to macro-evolution, which ultimately influences the structure of human populations. In the present paper and attempt has been made to study the distribution of Glucose-6-Phosphate Dehydrogenase Deficiency and Abnormal Haemoglobins (HBS and HBE) frequencies among the people of India, which are analysed in relation to ecological, socioeconomic and linguistic factors.

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The distribution of transferrin, group-specific component and phosphoglucomutase-1 subtypes among the Lepchas of Darjeeling, Eastern India

Cited by 6 publications

References 35 publications

Distribution of group-specific component (Gc) subtypes in several Mongoloid populations of East Asia

Distribution of group-specific component (Gc) subtypes in several Mongoloid populations of East Asia

Genetic relationships of the populations in eastern India

Genetics of Castes and Tribes of India: Glucose-6-Phosphate Dehydrogenase Deficiency and Abnormal Haemoglobins (HbS and HbE)

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