The diversity of gut microbiota in type 2 diabetes with or without cognitive impairment

Zhang, Yunyun; Lu, Shourong; Yang, Ying; Wang, Zhuo; Wang, Bin; Zhang, Bingshan; Yu, Jie; Liu, Wenwei; Pan, Mingluo; Zhao, Jianxin; Guo, Songlin; Cheng, Jin; Chen, Xiaorong; Hong, Kan; Li, Gang; Yu, Zhi‐Ming

doi:10.1007/s40520-020-01553-9

Cited by 43 publications

(29 citation statements)

References 21 publications

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“…Verrucomicrobia reverses cognitive dysfunction including impaired spatial working memory and recognition of new objects, restores brain metabolism [ 63 ], and alleviates memory impairment caused by high fat in mice [ 64 ]. Patients with cognitive impairment had a lower abundance of Tenericutes [ 65 ]. This is at odds with our data that showed a positive correlation between Tenericutes level and distance (r s = 0.474) and time (r s = 0.436) spent on the platform search in the water Morris maze ( Table S1 ).…”

Section: Discussionmentioning

confidence: 99%

Nrf2/ARE Activators Improve Memory in Aged Mice via Maintaining of Mitochondrial Quality Control of Brain and the Modulation of Gut Microbiome

et al. 2021

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Aging is one of the most serious factors for central nervous dysfunctions, which lead to cognitive impairment. New highly effective drugs are required to slow the development of cognitive dysfunction. This research studied the effect of dimethyl fumarate (DMF), methylene blue (MB), and resveratrol (RSV) on the cognitive functions of 15-month-old mice and their relationship to the maintenance of mitochondrial quality control in the brain and the bacterial composition of the gut microbiome. We have shown that studied compounds enhance mitochondrial biogenesis, mitophagy, and antioxidant defense in the hippocampus of 15-month-old mice via Nrf2/ARE pathway activation, which reduces the degree of oxidative damage to mtDNA. It is manifested in the improvement of short-term and long-term memory. We have also shown that memory improvement correlates with levels of Roseburia, Oscillibacter, ChristensenellaceaeR-7, Negativibacillus, and Faecalibaculum genera of bacteria. At the same time, long-term treatment by MB induced a decrease in gut microbiome diversity, but the other markers of dysbiosis were not observed. Thus, Nrf2/ARE activators have an impact on mitochondrial quality control and are associated with a positive change in the composition of the gut microbiome, which together lead to an improvement in memory in aged mice.

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Section: Discussionmentioning

confidence: 99%

Nrf2/ARE Activators Improve Memory in Aged Mice via Maintaining of Mitochondrial Quality Control of Brain and the Modulation of Gut Microbiome

et al. 2021

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“…DM has been associated with a high risk of developing cognitive impairment, and studies have shown that the Calcium signaling pathway affected gut microbiota, which improved cognitive impairment in patients with DM ( Zhang et al, 2020 ). The primary functions of toll-like receptors include the induction of inflammatory responses and the establishment of adaptive immunity.…”

Section: Discussionmentioning

confidence: 99%

An Integrative Pharmacology-Based Approach for Evaluating the Potential Effects of Purslane Seed in Diabetes Mellitus Treatment Using UHPLC-LTQ-Orbitrap and TCMIP V2.0

et al. 2021

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Portulaca oleracea L., known as the “vegetable for long life,” is an annual succulent herb that is widely distributed worldwide. Many clinical and experimental studies have demonstrated that purslane seed (MCXZ) can be used as an adjunctive and alternative therapy for the treatment of diabetes mellitus (DM). However, the underlying active constituents and pharmacological mechanisms through which MCXZ exerts effects in DM remain unclear. In the present study, we confirmed that MCXZ treatment resulted in hypoglycemic activity, lowering the fasting blood glucose and glycated hemoglobin levels in streptozotocin-induced diabetic mice. Then, ultra-high-pressure liquid chromatography coupled with linear ion trap-Orbitrap tandem mass spectrometry was used to systematically analyze the chemical profile of MCXZ, resulting in the identification of 84 constituents, including 31 organic acids and nine flavonoids. Finally, the Integrative Pharmacology-based Research Platform of Traditional Chinese Medicine was employed to analyze the key active components of MCXZ and the molecular mechanisms through which these components acted in DM. Ten key active compounds were identified based on the topological importance of their corresponding putative targets within the known DM-associated therapeutic target network of known MCXZ putative targets. Functionally, these candidate targets play critical anti-hyperlipidemia, anti-hyperglycemia, immunity regulation, and inflammatory roles involving DM-related pathways, such as the vascular endothelial growth factor (VEGF) signaling pathway and Fc gamma R-mediated phagocytosis, which indicated that MCXZ exhibited anti-diabetic activity through multi-faced actions.

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“…Spearman's analysis showed that Veillonella abundance rose as the MoCA score dropped. Previous studies have revealed that the abundance of Veillonella decreases in the case of cognitive impairment [ 64 ]. Veillonella species, as a harmless or even beneficial gram-negative anaerobic coccus, colonizes the mouth after one's birth [ 65 ].…”

Section: Discussionmentioning

confidence: 99%

Predictive Value of Gut Microbiome for Cognitive Impairment in Patients with Hypertension

Shen

Zhang

et al. 2021

Disease Markers

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A connection exists between hypertension (HTN) and cognitive impairment (CI) or gut microbiota (GM) and neuropsychiatric disease. However, the link between GM and HTNCI has not been illustrated. This study endeavoured to profile the landscape of GM in HTNCI patients and evaluate the value of GM as HTNCI biomarkers. We recruited 128 patients with hypertension and assigned them to two groups of different MoCA scores. Clinical and biological data were recorded. GM composition was illustrated with 16S ribosomal RNA sequencing, and the dominant species were identified by linear discriminant analysis Effect Size (LEfSe). It showed higher abundance of TM7 and lower abundances of Veillonella and Peptoniphilus in the HTNCI group than in the HTN without cognitive impairment (HTNnCI) group. We next clarified the link between GM and MoCA scores or HTNCI factors. KEGG analysis revealed the involvement of decreased bile secretion. An evident correlation showed up between HTNCI and Veillonella abundance ( P = 0.0340 ). We concluded that some representative GM species, especially Veillonella, could predict cognitive impairment in hypertension patients, making them potential benchmarks of HTNCI.

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The diversity of gut microbiota in type 2 diabetes with or without cognitive impairment

Cited by 43 publications

References 21 publications

Nrf2/ARE Activators Improve Memory in Aged Mice via Maintaining of Mitochondrial Quality Control of Brain and the Modulation of Gut Microbiome

Nrf2/ARE Activators Improve Memory in Aged Mice via Maintaining of Mitochondrial Quality Control of Brain and the Modulation of Gut Microbiome

An Integrative Pharmacology-Based Approach for Evaluating the Potential Effects of Purslane Seed in Diabetes Mellitus Treatment Using UHPLC-LTQ-Orbitrap and TCMIP V2.0

Predictive Value of Gut Microbiome for Cognitive Impairment in Patients with Hypertension

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