2004
DOI: 10.1016/j.biopsych.2004.08.013
|View full text |Cite
|
Sign up to set email alerts
|

The dopamine-4 receptor gene associated with binge eating and weight gain in women with seasonal affective disorder: An evolutionary perspective

Help me understand this report

Search citation statements

Order By: Relevance

Paper Sections

Select...
1
1
1
1

Citation Types

5
71
1
4

Year Published

2006
2006
2017
2017

Publication Types

Select...
8
1

Relationship

1
8

Authors

Journals

citations
Cited by 95 publications
(81 citation statements)
references
References 27 publications
5
71
1
4
Order By: Relevance
“…Our observations are in line with previous reports showing that the MC4R variant was associated with emotional eating and food cravings (5). Other studies have observed that MC4R interacts with the dopamine system, which is highly expressed in the brainÕs reward pathways and plays a key role in affecting eating behavior such as overeating (22,23).…”
Section: Figuresupporting
confidence: 83%
“…Our observations are in line with previous reports showing that the MC4R variant was associated with emotional eating and food cravings (5). Other studies have observed that MC4R interacts with the dopamine system, which is highly expressed in the brainÕs reward pathways and plays a key role in affecting eating behavior such as overeating (22,23).…”
Section: Figuresupporting
confidence: 83%
“…In a subsequent report, we demonstrated that the link between the 7R allele and weight gain was strongly mediated by binge eating (Levitan et al, 2004b), further suggesting that altered brain mechanisms relevant to feeding behavior might be involved in this association.…”
Section: Introduction Atypical Symptoms Of Depression and Obesity: Shmentioning
confidence: 69%
“…There is now significant evidence that the 7R allele in particular started off as a rare mutational event, and has been strongly positively selected for in various human populations over the past 40 000 years (Ding et al, 2002). We have previously suggested that the ability of young women to conserve body mass in the fall and winter months, mediated by an effect of the 7R allele on eating behavior, might have been a factor in this positive selection process (Levitan et al, 2004b). The current results further suggest that the 7R allele could play a role in a type of early developmental plasticity that matches adult feeding and activity patterns to predicted seasonal famines.…”
Section: The 7r Allele Of Drd4 As a Seasonal Thrifty Genotypementioning
confidence: 99%
“…Recently, Levitan et al 35 showed an association between the hypo functional 7-repeat allele of the DRD4 48 bp VNTR polymorphism with weight gain and obesity in women with SAD: Binge eating as reason for weight gain suggests that a dopamine dependent food reward process might be involved. Such mechanisms may have influenced the results of our study and further studies should include indices of eating behavior in order to clarify the nature of the obtained results.…”
Section: Discussionmentioning
confidence: 99%