Dietary Protein Modifies the Effect of the
            <i>MC4R</i>
            Genotype on 2-Year Changes in Appetite and Food Craving: The POUNDS Lost Trial

Huang, Tao; Zheng, Yan; Hruby, Adela; Williamson, Donald A.; Bray, George A.; Shen, Yiru; Sacks, Frank M.; Qi, Lü

doi:10.3945/jn.116.242958

Cited by 16 publications

(9 citation statements)

References 34 publications

(42 reference statements)

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“…Similarly, a greater BMI was shown in the apolipoprotein A2 ( APOA2 , rs5082) CC carriers who consumed a diet high in saturated fat compared to TT or TC carriers [ 17 ]. Protein intake has been found to modify the effect of the MC4R gene on obesity-related traits, such as appetite and food craving [ 18 ].…”

Section: Introductionmentioning

confidence: 99%

The Association between Obesity-Risk Genes and Gestational Weight Gain Is Modified by Dietary Intake in African American Women

Meng

Groth

2018

Journal of Nutrition and Metabolism

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Obesity-risk genes have been associated with dietary intake, appetite regulation, and gestational weight gain (GWG). The purpose of this study was to examine whether dietary intake including total energy intake and macronutrients modify or mediate the association between obesity-risk genes and GWG. An observational study was conducted with 85 African American pregnant women. Sociodemographic, medical, and lifestyle factors and dietary recalls were collected during pregnancy. Seven obesity-risk genetic variants were genotyped. Regression analyses with bootstrapping methods were used to examine the moderation and mediation effects of dietary intake. The mean GWG was 14.2 kg, and 55.3% of the women gained above the Institute of Medicine GWG guidelines. A nominally significant association was found between rs17782313 (close to MC4R) and percentage of energy intake from fat (P=0.043). A variant downstream of KCTD15 (rs11084753) was nominally significantly related to GWG (P=0.023). There was a significant interaction between the KCTD15 polymorphism and dietary fat intake (P=0.048). Women with the AG genotype gained more weight during pregnancy with more dietary fat consumption. In conclusion, our results indicate that dietary macronutrients, especially fat intake, may modify the effect of the KCTD15 gene on GWG. Improved knowledge of gene-diet interactions can facilitate the development of personalized interventions.

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Section: Introductionmentioning

confidence: 99%

The Association between Obesity-Risk Genes and Gestational Weight Gain Is Modified by Dietary Intake in African American Women

Meng

Groth

2018

Journal of Nutrition and Metabolism

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“…Most of the investigated genes were related to food intake control and regulation of energy homeostasis (i.e., FTO and MC3R) or glucose and lipid metabolism (i.e., ADIPOQ and CETP) [89,92,93]. Interestingly, genetic variants in the FTO and MC4R, both associated with appetite and food craving, have also been investigated for differential satiety in response to dietary protein intake [94,95]. Heterogeneous responses after low energy diets were also observed in terms of weight loss and inflammation reduction according to FTO, PPAR, and NPY [96,97], suggesting that different dietetic regimens in terms of macronutrients should be optimized to effectively reduce inflammation and improve lipid profile in subjects with different genetic backgrounds.…”

Section: Dietary Patternmentioning

confidence: 99%

Nutrigenetics—personalized nutrition in obesity and cardiovascular diseases

et al. 2020

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Epidemiological data support the view that both obesity and cardiovascular diseases (CVD) account for a high proportion of total morbidity and mortality in adults throughout the world. Obesity and CVD have complex interplay mechanisms of genetic and environmental factors, including diet. Nutrition is an environmental factor and it has a predominant and recognizable role in health management and in the prevention of obesity and obesity-related diseases, including CVD. However, there is a marked variation in CVD in patients with obesity and the same dietary pattern. The different genetic polymorphisms could explain this variation, which leads to the emergence of the concept of nutrigenetics. Nutritional genomics or nutrigenetics is the science that studies and characterizes gene variants associated with differential response to specific nutrients and relating this variation to various diseases, such as CVD related to obesity. Thus, the personalized nutrition recommendations, based on the knowledge of an individual's genetic background, might improve the outcomes of a specific dietary intervention and represent a new dietary approach to improve health, reducing obesity and CVD. Given these premises, it is intuitive to suppose that the elucidation of diet and gene interactions could support more specific and effective dietary interventions in both obesity and CVD prevention through personalized nutrition based on nutrigenetics. This review aims to briefly summarize the role of the most important genes associated with obesity and CVD and to clarify the knowledge about the relation between nutrition and gene expression and the role of the main nutrition-related genes in obesity and CVD.

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“…Существуют также рецепторы, ответственные за формирование пищевого поведения. Так, существует ген MC4R, роль которого определяется регулированием энергетического баланса [51]. Данный ген кодирует рецептор меланокортина-4 -одного из пяти рецепторов меланокортина, относящихся к семейству рецепторов, связанных с G-белками, представляющими собой семидоменные трансмембранные белки [51].…”

Section: рисунок 2 сигнальный путь T2r [22]unclassified

Taste receptors are our mediators in shaping the taste preferences of a child

et al. 2018

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The article presents modern data on the main molecular and genetic determinants of shaping the taste preferences. The authors present the structure and mechanism of the functioning of sweet taste receptors, umami taste, acidic and bitter tastes, as well as other molecules and cellular structures influencing the perception of flavors – the gust protein, toll-like receptors. They described the role of structures ensuring perception of taste outside the oral cavity – the cells of the hypothalamus. The article underlines the importance of the genetic polymorphism of these structures and the importance of interaction of genetic factors and environmental factors in shaping the taste preferences and eating behavior of the infant. Particular attention is given to the practical significance of the presented data in the context of introduction of supplemental foods for infants.

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Dietary Protein Modifies the Effect of the MC4R Genotype on 2-Year Changes in Appetite and Food Craving: The POUNDS Lost Trial

Abstract: Background: The melanocortin-4 receptor (MC4R) plays a pivotal role in the regulation of appetite and eating behavior.

Cited by 16 publications

References 34 publications

The Association between Obesity-Risk Genes and Gestational Weight Gain Is Modified by Dietary Intake in African American Women

The Association between Obesity-Risk Genes and Gestational Weight Gain Is Modified by Dietary Intake in African American Women

Nutrigenetics—personalized nutrition in obesity and cardiovascular diseases

Taste receptors are our mediators in shaping the taste preferences of a child

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