The dopamine D3/2 agonist 7-OH-DPAT attenuates the development of morphine tolerance but not physical dependence in rats

Cook, Charles D.; Barrett, Andrew C.; Syvanthong, Chockeo; Picker, Mitchell J.

doi:10.1007/s002130000520

Cited by 14 publications

(4 citation statements)

References 51 publications

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“…Although not essential, the D3 dopamine receptor also plays a role in mediating morphine-conditioned place preferences (Ashby et al, 2003; Frances et al, 2004; Narita et al, 2003). There are some studies suggesting that the D2-like dopamine receptors have a role in mediating the precipitation of somatic signs of morphine withdrawal, although the literature regarding the precise details of their involvement is conflicting (Cook et al, 2000; Funada and Shippenberg, 1996; Harris and Aston-Jones, 1994). The D2-like dopamine receptors were demonstrated to be involved in the emotional/aversive state caused by morphine withdrawal (Funada and Shippenberg, 1996; Smith et al, 2002).…”

Section: Discussionmentioning

confidence: 99%

Morphine alters the locomotor responses to a D2/D3 dopamine receptor agonist differentially in adolescent and adult mice

2012

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The D2-like dopamine receptors mediate the emotional/aversive state during morphine withdrawal. Given age-dependent differences in the affective responses to withdrawal, this study examined whether the response to dopamine receptor agonists is altered differentially across ages following morphine administration. Adolescent and adult mice were injected with morphine (twice daily, 10-40 mg/kg, s.c.) or saline for 6 days. Subsequently, they were examined for their locomotor response to quinpirole, a D2/D3 receptor agonist, and SKF 38393, a D1 receptor agonist. Quinpirole dose-dependently reduced locomotion in drug-naïve animals. Initial suppression was also observed in morphine-treated animals, but was followed by enhanced locomotion. Notably, this enhanced locomotion was markedly greater in adolescents than adults. Quinpirole-induced hypo-locomotion is thought to be mediated by the presynaptic D2Short receptors, whereas its activating effect is mediated by postsynaptic D2Long/D3 receptors. This suggests that following morphine administration, the postsynaptic, but not the presynaptic, dopaminergic signaling is differentially modulated across ages. This locomotor supersensitivity was not observed for SKF 38393, a D1 dopamine receptor agonist. The D2/D3 receptors are involved in the pathophysiology of many mental illnesses. Thus, this study offers a potential explanation for the increased psychiatric disorder co-morbidities when drug use begins during adolescence.

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Section: Discussionmentioning

confidence: 99%

Morphine alters the locomotor responses to a D2/D3 dopamine receptor agonist differentially in adolescent and adult mice

2012

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“…However, the mechanisms of the development of morphine tolerance are not completely identical. For example, 5-hydroxytryptamine exerts opposite action on the development (16) and maintenance (17) of opioid tolerance while the activation of GA-BA (18) and dopamine (19) receptors is only involved in the development of tolerance. Therefore, it is necessary to investigate the mechanisms underlying morphine tolerance.…”

Section: Discussionmentioning

confidence: 99%

“…Morphine has been demonstrated to activate spinal glial activity, enhance production of TNF-α and nitric oxide, and inhibit microglial chemotaxis (5,19). Morphine tolerance is associated with spinal microglial and astroglial activation (3,11,20).…”

Section: Discussionmentioning

confidence: 99%

Melanocortin 4 Receptor Is Involved in the Development of Morphine Tolerance

Xu¹,

Niu²,

H³

et al. 2014

J Anesth Perioper Med

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“…However, the effect of D 2 dopamine receptors on the expression of morphine tolerance has not been elucidated. Moreover, while some D 2 dopamine receptor agonists such as quinpirole can also exert agonistic effects on D 3 dopamine receptor (Vallone et al, 2000), the latter has been implicated in the regulation of morphine tolerance (Cook et al, 2000). In this study, we examined the effect of the D 2 /D 3 -R agonist, quinpirole, and the D 2 -R antagonist, sulpiride, on the expression of morphine tolerance using the tail-flick test in mice.…”

Section: Introductionmentioning

confidence: 99%

Dopamine receptor mechanism(s) and morphine tolerance in mice

Zarrindast

Dinkoub²,

Homayoun³

et al. 2002

J Psychopharmacol

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Based on our previous demonstration of the involvement of dopamine-2 (D2) dopamine receptors in morphine antinociception, we examined the role of D2 dopamine receptors in the expression and development of tolerance to morphine antinociception in mice. Tolerance to morphine antinociception was assessed by the tail-flick response after the administration of morphine (50 mg/kg) once daily for 3 days. The D2 dopamine receptor agonist, quinpirole (0.01, 0.02 and 0.03 mg/kg), but not the D2 dopamine receptor antagonist, sulpiride (12.5, 25 and 50 mg/kg), increased morphine antinociception in morphine non pre-exposed mice. The response of quinpirole was decreased by the lower doses of sulpiride. Both quinpirole and sulpiride decreased the expression and development of tolerance to antinociception induced by morphine (1.5, 3 and 6 mg/kg). The effect of quinpirole on the expression and development of tolerance, was reduced by a lower and per se non-effective dose of sulpiride. It was concluded that D2 dopaminergic receptors may play a part in the expression and development of tolerance to the antinociceptive effect of morphine.

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The dopamine D3/2 agonist 7-OH-DPAT attenuates the development of morphine tolerance but not physical dependence in rats

Abstract: The D3/2 agonist 7-OH-DPAT can attenuate the antinociceptive effects of morphine in both acute and chronic preparations as well as the development of morphine tolerance. 7-OH-DPAT does not, however, alter morphine physical dependence.

Cited by 14 publications

References 51 publications

Morphine alters the locomotor responses to a D2/D3 dopamine receptor agonist differentially in adolescent and adult mice

Morphine alters the locomotor responses to a D2/D3 dopamine receptor agonist differentially in adolescent and adult mice

Melanocortin 4 Receptor Is Involved in the Development of Morphine Tolerance

Dopamine receptor mechanism(s) and morphine tolerance in mice

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