The Dose-Response Relationship between Alcohol Consumption and the Risk of Type 2 Diabetes among Asian Men: A Systematic Review and Meta-Analysis of Prospective Cohort Studies

Han, Manman

doi:10.1155/2020/1032049

Cited by 14 publications

(20 citation statements)

References 36 publications

(80 reference statements)

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“…Li et al showed a positive correlation of dose‐dependent effect of duration of alcohol consumption with the development of impaired glucose tolerance 8 . Han et al found that alcohol intake of >57 g/day was associated with an increased risk of development of prediabetes and diabetes mellitus 7 . The dose‐dependent effect of alcohol consumption aligns with our finding of increased incidence of stroke in geriatric prediabetic patients with AUD by 33%.…”

Section: Discussionsupporting

confidence: 85%

“…8 Han et al found that alcohol intake of >57 g/day was associated with an increased risk of development of prediabetes and diabetes mellitus. 7 The dose-dependent effect of alcohol consumption aligns with our finding of increased incidence of stroke in geriatric prediabetic patients with AUD by 33%. Due to the dose-dependent effect of alcohol consumption in the development of prediabetes, geriatric patients with a history of long-term alcohol abuse likely to have a stroke with prediabetes.…”

Section: Discussionsupporting

confidence: 82%

“…In this study, nearly 3% of geriatric admissions with known prediabetes demonstrated concomitant AUD. Various studies have evaluated the role of alcohol consumption in the development of prediabetes and type 2 diabetes mellitus (T2DM) 1,7,8 . Consumption of alcohol leads to the production of reactive oxygen species, which can impair B‐cell mitochondrial function, leading to apoptosis 1 .…”

Section: Discussionmentioning

confidence: 99%

“…The dose‐dependent effect of alcohol consumption aligns with our finding of increased incidence of stroke in geriatric prediabetic patients with AUD by 33%. Due to the dose‐dependent effect of alcohol consumption in the development of prediabetes, geriatric patients with a history of long‐term alcohol abuse likely to have a stroke with prediabetes 7,8 . Alcohol consumption and impaired glucose tolerance are known independent risk factors of stroke; thus in our analysis, we assessed the risk of stroke in the geriatric prediabetic population with concomitant AUD.…”

Section: Discussionmentioning

confidence: 99%

“…Various studies have evaluated the role of alcohol consumption in the development of prediabetes and type 2 diabetes mellitus (T2DM). 1,7,8 Consumption of alcohol leads to the production of reactive oxygen species, which can impair B-cell mitochondrial function, leading to apoptosis. 1 Secondarily, metabolites of alcohol like acetaldehyde toxicity, excess fatty acid and triglyceride synthesis may contribute to the development of prediabetes and T2DM.…”

Section: Discussionmentioning

confidence: 99%

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Impact of alcohol use disorder on stroke risk in geriatric patients with prediabetes: A nationwide analysis

et al. 2021

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Background With rising trends of prediabetes in the geriatric population, we aim to assess the impact of alcohol use disorder (AUD) on the outcomes of patients with prediabetes. Methods Hospitalisations amongst the patients (≥65 years) with prediabetes were identified with a diagnosis of AUD and in‐hospital stroke using the National Inpatient Sample database (2007‐2014). We compared demographics, comorbidities, all‐cause mortality, stroke rate and resource utilisation in the elderly prediabetes patients with vs without AUD. Primary outcomes of interest were all‐cause mortality and stroke rate, whereas secondary outcomes were the length of stay (days), disposition and resource utilisation in the AUD cohort as compared to the non‐AUD cohort. Results We had a total of 1.7 million hospitalisations amongst elderly patients with prediabetes, 2.8% (n = 47 962) had AUD. The AUD cohort was more often younger (71 vs 77 years), male (74.1% vs 43.5%) and nonelectively (84.5% vs 78.3%) admitted than non‐AUD cohort. The AUD cohort more often consisted of African Americans (9.0% vs 6.6%) and Hispanics (5.3% vs 5.1%) than non‐AUD cohort. The AUD cohort showed higher rates of smoking, drug abuse, chronic obstructive pulmonary disease, coagulopathy, peripheral vascular disease and fluid‐electrolyte disorders whereas a lower rate of cardiovascular risk factors than non‐AUD cohort. All‐cause mortality (4.4% vs 3.9%) and stroke (5.5% vs 4.8%, aOR 1.33, 95% CI 1.28‐1.39) were significantly higher in the AUD cohort with prolonged stay, higher charges and frequent transfers than non‐AUD cohort. Conclusion AUD in the elderly prediabetes patients increases the stroke risk by up to 33% which can adversely influence the survival rate and healthcare infrastructure.

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Section: Discussionsupporting

confidence: 85%

Section: Discussionsupporting

confidence: 82%

Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

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Impact of alcohol use disorder on stroke risk in geriatric patients with prediabetes: A nationwide analysis

et al. 2021

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Association of alcohol drinking with incident type 2 diabetes and pre‐diabetes: The Guangzhou Biobank Cohort Study

Ren

Zhang

et al. 2022

Diabetes Metabolism Res

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Background To examine associations of baseline alcohol drinking with incident type 2 diabetes or impaired fasting glucose, and explore whether the associations were modi ed by genetic polymorphisms of aldehyde dehydrogenase-2 (ALDH2) and alcohol dehydrogenase-1B (ADH1B).Methods Information of alcohol consumption was collected at baseline from 2003 to 2008. Incident type 2 diabetes was de ned as fasting glucose ≥7.0 mmol/l or post-load glucose ≥11.1 mmol/l at follow-up examination (2008)(2009)(2010)(2011)(2012), self-reported type 2 diabetes and/or initiation of hypoglycemia medication or insulin during follow-up. Impaired fasting glucose was de ned as fasting glucose ≥5.6 mmol/l and <7 mmol/l. ResultsOf 15,716 participants without diabetes and 11,232 participants without diabetes and impaired fasting glucose at baseline, 1,624 (10.33%) developed incident type 2 diabetes, and 1,004 (8.94%) developed incident impaired fasting glucose during average 4 years of follow-up. After adjusting for sex, age, education, occupation, personal annual income, smoking, physical activity, body mass index, waist/hip ratio, health status, family history of diabetes, compared with never drinking, occasional or moderate alcohol drinking was not associated with risk of incident type 2 diabetes+impaired fasting glucose (odds ratio (OR) 1.08, 95% con dence interval (CI) 0.94-1.25, and 0.89 (0.68-1.16), respectively), but heavy alcohol drinking was associated with a higher risk of incident type 2 diabetes+impaired fasting glucose (1.83, 1.25-2.69). No interactions of sex, overweight/obesity and genetic polymorphisms of ADH1B or ALDH2 genes with alcohol drinking on incident type 2 diabetes and/or impaired fasting glucose were found (p for interaction from 0.12 to 0.81).Conclusions Our results support a detrimental effect of heavy alcohol use on impaired fasting glucose and type 2 diabetes. No protective effect was found for those carrying lower risk alleles for ADH1B and ALDH2 genes.

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Metabolite patterns link diet, obesity, and type 2 diabetes in a Hispanic population

et al. 2021

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Introduction Obesity is a precursor of type 2 diabetes (T2D). Objectives Our aim was to identify metabolic signatures of T2D and dietary factors unique to obesity. Methods We examined a subsample of the Boston Puerto Rican Health Study (BPRHS) population with a high prevalence of obesity and T2D at baseline (n = 806) and participants (without T2D at baseline) at 5-year follow-up (n = 412). We determined differences in metabolite profiles between T2D and non-T2D participants of the whole sample and according to abdominal obesity status. Enrichment analysis was performed to identify metabolic pathways that were over-represented by metabolites that differed between T2D and non-T2D participants. T2D-associated metabolites unique to obesity were examined for correlation with dietary food groups to understand metabolic links between dietary intake and T2D risk. False Discovery Rate method was used to correct for multiple testing. Results Of 526 targeted metabolites, 179 differed between T2D and non-T2D in the whole sample, 64 in non-obese participants and 120 unique to participants with abdominal obesity. Twenty-four of 120 metabolites were replicated and were associated with T2D incidence at 5-year follow-up. Enrichment analysis pointed to three metabolic pathways that were overrepresented in obesity-associated T2D: phosphatidylethanolamine (PE), long-chain fatty acids, and glutamate metabolism. Elevated intakes of three food groups, energy-dense takeout food, dairy intake and sugar-sweetened beverages, associated with 13 metabolites represented by the three pathways. Conclusion Metabolic signatures of lipid and glutamate metabolism link obesity to T2D, in parallel with increased intake of dairy and sugar-sweetened beverages, thereby providing insight into the relationship between dietary habits and T2D risk.

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The Dose-Response Relationship between Alcohol Consumption and the Risk of Type 2 Diabetes among Asian Men: A Systematic Review and Meta-Analysis of Prospective Cohort Studies

Cited by 14 publications

References 36 publications

Impact of alcohol use disorder on stroke risk in geriatric patients with prediabetes: A nationwide analysis

Impact of alcohol use disorder on stroke risk in geriatric patients with prediabetes: A nationwide analysis

Association of alcohol drinking with incident type 2 diabetes and pre‐diabetes: The Guangzhou Biobank Cohort Study

Metabolite patterns link diet, obesity, and type 2 diabetes in a Hispanic population

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