The Dose-Response Relationship Between Body Mass Index and the Risk of Incident Stage ^|^ge;3 Chronic Kidney Disease in a General Japanese Population: The Ibaraki Prefectural Health Study (IPHS)

Tsujimoto, Takehiko; Sairenchi, Toshimi; Iso, Hiroyasu; Irie, Fujiko; Yamagishi, Kazumasa; Watanabe, Hiroshi; Tanaka, Kiyoji; Muto, Takashi; Ota, Hitoshi

doi:10.2188/jea.je20140028

Cited by 63 publications

(53 citation statements)

References 26 publications

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“…For example, among 105 611 Japanese adults with normal underlying kidney function who were stratified by sex, a graded association between higher BMI levels and risk of incident CKD was observed in both men and women (albeit at different BMI thresholds of more than 23.0 and 27.0 kg/m 2 , respectively) after a mean follow-up of 5 years [11]. In addition, Vivante et al .…”

Section: Obesity and Risk Of Incident Chronic Kidney Diseasementioning

confidence: 99%

The dual roles of obesity in chronic kidney disease

Rhee

Ahmadi

Kalantar-Zadeh

2016

Current Opinion in Nephrology and Hypertension

101

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Purpose of review Obesity is a major risk factor for the development of de novo chronic kidney disease (CKD). However, once kidney disease is acquired, obesity is paradoxically linked with greater survival, especially in those with advanced CKD. This review examines current evidence for obesity as a risk factor for incident CKD, studies of obesity and mortality across various CKD populations, and potential mechanisms underlying the ‘obesity paradox’ in kidney disease. Recent findings Large cohort studies show that overweight body habitus, especially in the context of metabolic syndrome, is associated with higher risk of incident CKD. Emerging data also suggest weight-loss interventions retard or reverse early CKD progression, whereas in hemodialysis patients weight-loss paradoxically heralds poor outcomes. Although the pathogenesis of CKD in obesity remains unclear, studies indicate that excess body fat leads to kidney disease via indirect and direct mechanisms. Meta-analyses suggest that overweight and obese BMI ranges are counterintuitively associated with lower mortality in advanced predialysis and dialysis-dependent CKD patients, whereas a pooled analysis observed that higher pretransplantation BMI was associated with higher mortality in kidney transplantation recipients. Summary In addition to its role as a risk factor for de novo CKD, there appears to be a consistent association between obesity and lower mortality in those with established CKD, particularly among hemodialysis patients, suggesting that the reverse epidemiology of obesity is biologically plausible.

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Section: Obesity and Risk Of Incident Chronic Kidney Diseasementioning

confidence: 99%

The dual roles of obesity in chronic kidney disease

Rhee

Ahmadi

Kalantar-Zadeh

2016

Current Opinion in Nephrology and Hypertension

101

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“…A high body mass index (BMI) is one of the strongest risk factors for new-onset CKD. 6,7 Definitions of obesity are most often based on BMI (i.e. weight [kilograms] divided by the square of his or her height [metres]).…”

Section: Epidemiology Of Obesity In Adults and Childrenmentioning

confidence: 99%

Obesity and kidney disease: hidden consequences of the epidemic

Kövesdy

Furth

Zoccali

2017

Journal of Endocrinology, Metabolism and Diabetes of South Afri

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Obesity has become a worldwide epidemic, and its prevalence has been projected to grow by 40% in the next decade. This increasing prevalence has implications for the risk of diabetes, cardiovascular disease and also for chronic kidney disease. A high body mass index is one of the strongest risk factors for new-onset chronic kidney disease. In individuals affected by obesity, a compensatory hyperfiltration occurs to meet the heightened metabolic demands of the increased bodyweight. The increase in intraglomerular pressure can damage the kidneys and raise the risk of developing chronic kidney disease in the long term. The incidence of obesity-related glomerulopathy has increased tenfold in recent years. Obesity has also been shown to be a risk factor for nephrolithiasis, and for a number of malignancies including kidney cancer. This year World Kidney Day promotes education on the harmful consequences of obesity and its association with kidney disease, advocating a healthy lifestyle and health policy measures that makes preventive behaviours an affordable option.

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“…A high BMI is one of the strongest risk factors for new-onset CKD. 6,7 Definitions of obesity are most often based on BMI (i.e. weight [kilograms] divided by the square of his or her height [meters]).…”

mentioning

confidence: 99%