The double isotope tracer method is a reliable measure of fractional zinc absorption

King, JC; Lowe, Nicola M; Jackson, Malcolm J.; Shames, DM

doi:10.1038/sj.ejcn.1600489

Cited by 5 publications

(2 citation statements)

References 2 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…FA results from all three samples agreed well with the expected absorbance value. King et al (43) concluded that "... the double isotope tracer method is a more accurate measure of zinc FA than is the fecal monitoring method ..."…”

Section: Famentioning

confidence: 99%

Stable Isotopes of Minerals as Metabolic Tracers in Human Nutrition Research

Patterson

Veillon

2001

Exp Biol Med (Maywood)

View full text Add to dashboard Cite

Enriched stable isotopes used as tracers have proven to be valuable in studies of the absorption and metabolism of minerals. Unlike radioisotopes, they can be used in high-risk population groups such as infants, children, and pregnant or lactating women. Estimates of mineral absorption can be made from the oral administration of a single tracer or from two tracers, one given orally and the other intravenously (IV). It is possible to determine the metabolism of the mineral with modeling based on the amount of the tracer or tracers in different biological samples. One of the key decisions in studies of this type is determining which enriched isotope and what amount to use. An example is given of calculations to estimate and compare the amounts of tracers needed for an absorption study. Methods for calculating the amounts of tracer in oral and IV doses are presented, and limits of detection and quantitation are discussed in terms of percent of enrichment and related to isotope ratio measurement precision. A general review of the use of mass spectrometric instruments for quantifying various stable isotopes is given.

show abstract

Section: Famentioning

confidence: 99%

Stable Isotopes of Minerals as Metabolic Tracers in Human Nutrition Research

Patterson

Veillon

2001

Exp Biol Med (Maywood)

View full text Add to dashboard Cite

show abstract

“…Friel et al (3) found "good agreement" between the two methods, but Rautscher and Fairweather-Tait (8) concluded that DITR does "not reliably predict" FZA. On the basis of a number of experimental and simulation considerations, we believe that the fecal monitoring method is an inappropriate reference for assessing DITR (5,9). In addition, we believe that the latter method does provide a valid estimate of FZA (9).…”

mentioning

confidence: 99%

Double isotope tracer method for measuring fractional zinc absorption: theoretical analysis

Sparacino

Shames

Vicini

et al. 2002

American Journal of Physiology-Endocrinology and Metabolism

View full text Add to dashboard Cite

Several approaches for estimation of fractional zinc absorption (FZA) by calculating the ratio of oral to intravenous stable isotopic tracer concentrations (at an appropriate time) in urine or plasma after their simultaneous administration have been proposed in the last decade. These simple-to-implement approaches, often referred to as the double isotopic tracer ratio (DITR) method, are more attractive than the classical “deconvolution” method and the more commonly used single-tracer methods based on fecal monitoring and indicator dilution, after oral or intravenous tracer administration, respectively. However, the domain of validity of DITR for measuring FZA has recently been questioned. In this paper, we provide a theoretical justification of the validity of four different “approximate” formulations of the DITR technique by demonstrating mathematically that their accuracy is a consequence of the particular properties of zinc kinetics.

show abstract

Studies on zinc bioavailability from a representative diet in Chinese urban women of childbearing age using a double label stable isotope technique

Yang

Piao

et al. 2005

Journal of Trace Elements in Medicine and Biology

View full text Add to dashboard Cite

The double isotope tracer method is a reliable measure of fractional zinc absorption

Cited by 5 publications

References 2 publications

Stable Isotopes of Minerals as Metabolic Tracers in Human Nutrition Research

Stable Isotopes of Minerals as Metabolic Tracers in Human Nutrition Research

Double isotope tracer method for measuring fractional zinc absorption: theoretical analysis

Studies on zinc bioavailability from a representative diet in Chinese urban women of childbearing age using a double label stable isotope technique

Contact Info

Product

Resources

About