The drosophila schnurri gene acts in the Dpp/TGFβ signaling pathway and encodes a transcription factor homologous to the human MBP family

Arora, Kavita; Dai, Heng; Kazuko, Sandra G.; Jamal, J.; O’Connor, Michael B.; Letsou, Anthea; Warrior, Rahul

doi:10.1016/0092-8674(95)90539-1

Cited by 206 publications

(115 citation statements)

References 41 publications

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“…3A, bottom ;Campbell and Tomlinson, 1999;Jaźwiń ska et al, 1999a,b;Minami et al, 1999). A critical transcription factor mediating this DPP-dependent repression of brinker is the zinc finger DNA-binding protein Schnurri (Shn; German for whiskers; Arora et al, 1995;Grieder et al, 1995;Staehling-Hampton et al, 1995). shn encodes a large protein (ϳ275 kDa) composed of eight zinc fingers (arranged in four clusters), which interacts with Smads (Mad and Medea, orthologs of vertebrate Smads 1/5/8 and 4, respectively) to mediate DPP signaling (Dai et al, 2000;Udagawa et al, 2000).…”

Section: Schnurri a Transcriptional Partner With Multiple Personalitiesmentioning

confidence: 99%

Finding partners: How BMPs select their targets

Blitz

Cho

2009

Developmental Dynamics

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The bone morphogenetic protein (BMP) signaling pathway is a conserved and evolutionarily ancient regulatory module affecting a large variety of cellular behaviors. The evolutionary flexibility in using BMP responses presumably arose by co-option of a canonical BMP signaling cascade to regulate the transcription of diverse batteries of target genes. This begs the question of how seemingly interchangeable BMP signaling components elicit widely different outputs in different cell types, an important issue in the context of understanding how BMP signaling integrates with gene regulatory networks to control development. Because a molecular understanding of how BMP signaling activates different batteries of target genes is an essential prerequisite to comprehending the roles of BMPs in regulating cellular responses, here we review the current knowledge of how BMP-regulated target genes are selected by the signal transduction machinery. We highlight recent studies suggesting the evolutionary conservation of BMP target gene regulation signaling by Schnurri family zinc finger proteins.

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Section: Schnurri a Transcriptional Partner With Multiple Personalitiesmentioning

confidence: 99%

Finding partners: How BMPs select their targets

Blitz

Cho

2009

Developmental Dynamics

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“…Originally described in Drosophila (Arora et al 1995;Grieder et al 1995;Staehling-Hampton et al 1995), Schnurri binding to the SMAD1/5-SMAD4-binding sites GRCGNC-N 5 -GTCT described above is thought explain the requirement for the N 5 spacing (Fig. 1B) (Pyrowolakis et al 2004).…”

Section: Transcription Factors Interacting With Smad1/5mentioning

confidence: 99%

Transcriptional Control by the SMADs

Hill

2016

Cold Spring Harb Perspect Biol

289

256

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The transforming growth factor-b (TGF-b) family of ligands elicit their biological effects by initiating new programs of gene expression. The best understood signal transducers for these ligands are the SMADs, which essentially act as transcription factors that are activated in the cytoplasm and then accumulate in the nucleus in response to ligand induction where they bind to enhancer/promoter sequences in the regulatory regions of target genes to either activate or repress transcription. This review focuses on the mechanisms whereby the SMADs achieve this and the functional implications. The SMAD complexes have weak affinity for DNA and limited specificity and, thus, they cooperate with other site-specific transcription factors that act either to actively recruit the SMAD complexes or to stabilize their DNA binding. In some situations, these cooperating transcription factors function to integrate the signals from TGF-b family ligands with environmental cues or with information about cell lineage. Activated SMAD complexes regulate transcription via remodeling of the chromatin template. Consistent with this, they recruit a variety of coactivators and corepressors to the chromatin, which either directly or indirectly modify histones and/or modulate chromatin structure.

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“…Both Spalt (Lecuit et al 1996;Nellen et al 1996) and the PRDII-BF1 family member Schnurri (Arora et al 1995;Grieder et al 1995) have been shown to be targets of signaling by the TGF-f3-1ike protein Decapentaplegic. The sequence similarities among SEM-4, Spalt, and PRDII-BF1 family members raise the possibility that SEM-4 activity might also be controlled by a signal transduction pathway.…”

Section: V5paapp Cell Death Pnp Hypodermal Cellsmentioning

confidence: 99%

“…This family includes the human proteins MBP-2 (van't Veer et al 1992) and KBP-1 (van't Veer et al 1992), as well as the Drosophila protein Schnurri (Arora et al 1995;Grieder et al 1995), which acts in the signaling pathway mediated by the transformation growth factor-~ (TGFq3)-related growth factor Decapentaplegic. The zinc fingers in SEM-4 and Spah are more similar to each other than to the zinc fingers in PRDII-BF1, MBP-2, KBP-1, or Schnurri, indicating that SEM-4 and Spah are more closely related to each other than to the other proteins.…”

Section: The Sem-4 Protein Contains Pairs Of Zinc Fingers That Are Simentioning

confidence: 99%

The Caenorhabditis elegans gene sem-4 controls neuronal and mesodermal cell development and encodes a zinc finger protein.

Basson¹,

Horvitz²

1996

Genes Dev.

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The large number of different types of neurons in both vertebrate and invertebrate nervous systems raises the question of how the development of a particular neuronal cell type is specified. To pursue this question, Desai et al. (1988;Desai and Horvitz 1989) initiated a genetic analysis of the HSN serotonergic motor neurons in Caenorhabditis elegans. This analysis identified genes that are required for a number of distinct aspects of HSN development and placed these genes in a pathway of gene action. Some of these genes encode types of proteins that have been shown to control neuronal development in other organisms. Examples of such genes are egl-5, which encodes a homeo domain protein (Wang et al. 1993); unc-6, which encodes a member of the netrin family {Serafini et al. 1994); unc-33, which encodes a protein that is related to CRMP-62, a chick collapsin response mediator protein (Goshima et al. 1995); and unc-86, which encodes a POU homeo domain protein (Finney and Ruvkun 1990). This correlation between the types of proteins that control HSN development and the types of proteins that control neuronal development in other organisms suggests that study of HSN development will reveal general principles of how neuronal cell type is specified.~Corresponding author.The POU gene unc-86 is required for the normal pattern of HSN axonal outgrowth, normal HSN nuclear morphology, and HSN serotonin expression (Desai et al. 1988). POU homeo domain proteins have been shown to be required for neuronal development in both Drosophila (Bhat et al. 1995;Yeo et al. 1995) and mammals (for review, see Sharp and Morgan 1996). Mutation of the C. elegans gene sere-4 (sex muscle defective) causes the same spectrum of defects in HSN development as that caused by mutation of unc-86 (Desai et al. 1988). Because POU homeo domain proteins seem likely to play an evolutionarily conserved role in neuronal development, we are interested in determining how the SEM-4 and UNC-86 proteins interact in controlling HSN development. To understand how sem-4 functions in HSN development as well as in the development of other cell types, we have performed a genetic and molecular analysis of sere-4.

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The drosophila schnurri gene acts in the Dpp/TGFβ signaling pathway and encodes a transcription factor homologous to the human MBP family

Cited by 206 publications

References 41 publications

Finding partners: How BMPs select their targets

Finding partners: How BMPs select their targets

Transcriptional Control by the SMADs

The Caenorhabditis elegans gene sem-4 controls neuronal and mesodermal cell development and encodes a zinc finger protein.

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