The Drosophila segment polarity gene dishevelled encodes a novel protein required for response to the wingless signal.

Role of Rho family GTPases in epithelial morphogenesis

“…the scaffold protein Disheveled (Dsh) that is recruited from the cytoplasm to adherens junctions by Fz (Klingensmith et al 1994;Theisen et al 1994;Krasnow et al 1995). Homologs of both Frizzled and Disheveled have been identified in vertebrates.…”

Dickkopf-1, an inhibitor of the Wnt signaling pathway, is induced by p53

“…Genetic studies have demonstrated that the Wnt proteins serve as intercellular signaling molecules and play key roles in embryogenesis, segment polarity, central nervous system (CNS) patterning, and the control of asymmetric cell divisions (Wodarz and Nusse, 1998). Wnt signaling events are initiated by the binding of Wnt to its receptor, Frizzled (Krasnow et al, 1995;Wong and Adler, 1993), which leads to activation of the Dishevelled protein (Klingensmith et al, 1994;Krasnow et al, 1995;Theisen et al, 1994). The activated Dishevelled protein enhances the phosphorylation of glycogen synthase kinase (GSK) (Cook et al, 1996), which inhibits the ability of GSK to phosphorylate b-catenin, leading to increased stability and accumulation of b-catenin (Munemitsu et al, 1996;Pai et al, 1997;Yost et al, 1996).…”

Cell type‐ and promoter‐dependent modulation of the Wnt signaling pathway by sodium butyrate

“…[1][2][3][4] Active GSK-3␤, in conjunction with the product of the adenomatous polyposis coli (APC) gene, promotes the degradation of ␤-catenin. [5][6][7] However, when ␤-catenin degradation is abrogated by induction of the Wnt pathway or by APC mutation, increased levels of free ␤-catenin in the cell nucleus can interact with the Tcf/Lef family 8 of DNA binding proteins, 9 -12 forming an active ␤-catenin-Tcf (BCT) transcriptional complex.…”