The dual-effects of PLGA@MT electrospun nanofiber coatings on promoting osteogenesis at the titanium–bone interface under diabetic conditions

Wang, Zijie; Chen, Tingting; Wu, Zimei; Jiang, Xingzhu; Hou, Qiaodan; Miao, Sikai; Xia, Ruihao; Wang, Lin

doi:10.1039/d2tb00120a

Cited by 9 publications

(2 citation statements)

References 37 publications

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“…In vitro culturing of BMMSCs on SF@MT nanofibers resulted in a significant improvement in their osteogenic differentiation, as evidenced by the high level of ALP activity, increased calcium deposition, and up-regulation of osteoblast-specific marker genes. In accordance with our findings, the incorporation of melatonin into poly(lactic- co -glycolic acid) electrospun nanofibers demonstrated the ability to induce osteogenesis through the activation of the Wnt/β-catenin signaling pathway, leading to enhanced osteointegration at the titanium-bone interface, even in mice with type 1 diabetes mellitus [ 30 ]. However, it should be noted that electrospun nanofiber membranes suffer from a lack of mechanical support.…”

Section: Discussionsupporting

confidence: 87%

Melatonin-encapsuled silk fibroin electrospun nanofibers promote vascularized bone regeneration through regulation of osteogenesis-angiogenesis coupling

Deng,

Hou,

et al. 2024

Materials Today Bio

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Section: Discussionsupporting

confidence: 87%

Melatonin-encapsuled silk fibroin electrospun nanofibers promote vascularized bone regeneration through regulation of osteogenesis-angiogenesis coupling

Deng,

Hou,

et al. 2024

Materials Today Bio

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“… 19 , 20 Our previous study found that MT electrospun nanofiber coatings protect osteoblasts by inhibiting ROS overproduction and directly improving osteogenesis via the BMP/WNT pathway under diabetic conditions. 21 Nevertheless, the widespread use of MT is hindered by several challenges, including inadequate stability, easy degradation, and limited bioavailability. To overcome these limitations, the current approach involves developing drug-carrier systems to facilitate controlled and sustained drug release.…”

Section: Introductionmentioning

confidence: 99%

The Dual Angiogenesis Effects via Nrf2/HO-1 Signaling Pathway of Melatonin Nanocomposite Scaffold on Promoting Diabetic Bone Defect Repair

Chen,

Wu,

Hou

et al. 2024

IJN

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Purpose Given the escalating prevalence of diabetes, the demand for specific bone graft materials is increasing, owing to the greater tendency towards bone defects and more difficult defect repair resulting from diabetic bone disease (DBD). Melatonin (MT), which is known for its potent antioxidant properties, has been shown to stimulate both osteogenesis and angiogenesis. Methods MT was formulated into MT@PLGA nanoparticles (NPs), mixed with sodium alginate (SA) hydrogel, and contained within a 3D printing polycaprolactone/β-Tricalcium phosphate (PCL/β-TCP) scaffold. The osteogenic capacity of the MT nanocomposite scaffold under diabetic conditions was demonstrated via in vitro and in vivo studies and the underlying mechanisms were investigated. Results Physicochemical characterization experiments confirmed the successful fabrication of the MT nanocomposite scaffold, which can achieve long-lasting sustained release of MT. The in vitro and in vivo studies demonstrated that the MT nanocomposite scaffold exhibited enhanced osteogenic capacity, which was elucidated by the dual angiogenesis effects activated through the NF-E2–related factor 2/Heme oxygenase 1 (Nrf2/HO-1) signaling pathway, including the enhancement of antioxidant enzyme activity to reduce the oxidative stress damage of vascular endothelial cells (VECs) and directly stimulating vascular endothelial growth factor (VEGF) production, which reversed the angiogenesis-osteogenesis uncoupling and promoted osteogenesis under diabetic conditions. Conclusion This study demonstrated the research prospective and clinical implications of the MT nanocomposite scaffold as a novel bone graft for treating bone defect and enhancing bone fusion in diabetic individuals.

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3D Bioprinting Strategies for Melatonin‐Loaded Polymers in Bone Tissue Engineering

Aykora,

Oral,

Aydeğer

et al. 2024

Macro Materials & Eng

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Bone pathologies are still among the most challenging issues for orthopedics. Over the past decade, different methods are developed for bone repair. In addition to advanced surgical and graft techniques, polymer‐based biomaterials, bioactive glass, chitosan, hydrogels, nanoparticles, and cell‐derived exosomes are used for bone healing strategies. Owing to their variation and promising advantages, most of these methods are not translated into clinical practice. Three dimensonal (3D) bioprinting is an additive manufacturing technique that has become a next‐generation biomaterial technique adapted for anatomic modeling, artificial tissue or organs, grafting, and bridging tissues. Polymer‐based biomaterials are mostly used for the controlled release of various drugs, therapeutic agents, mesenchymal stem cells, ions, and growth factors. Polymers are now among the most preferable materials for 3D bioprinting. Melatonin is a well‐known antioxidant with many osteoinductive properties and is one of the key hormones in the brain–bone axis. 3D bioprinted melatonin‐loaded polymers with unique lipophilic, anti‐inflammatory, antioxidant, and osteoinductive properties for filling large bone gaps following fractures or congenital bone deformities may be developed in the future. This study summarized the benefits of 3D bioprinted and polymeric materials integrated with melatonin for sustained release in bone regeneration approaches.

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The dual-effects of PLGA@MT electrospun nanofiber coatings on promoting osteogenesis at the titanium–bone interface under diabetic conditions

Abstract: A novel therapeutic strategy for promoting titanium–bone interface bone integration under diabetic conditions by fabricating PLGA@MT electrospun nanofiber coatings.

Cited by 9 publications

References 37 publications

Melatonin-encapsuled silk fibroin electrospun nanofibers promote vascularized bone regeneration through regulation of osteogenesis-angiogenesis coupling

Melatonin-encapsuled silk fibroin electrospun nanofibers promote vascularized bone regeneration through regulation of osteogenesis-angiogenesis coupling

The Dual Angiogenesis Effects via Nrf2/HO-1 Signaling Pathway of Melatonin Nanocomposite Scaffold on Promoting Diabetic Bone Defect Repair

3D Bioprinting Strategies for Melatonin‐Loaded Polymers in Bone Tissue Engineering

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