The dual modulatory effect of folic acid supplementation on indomethacin- induced gastropathy in the rat

Ajeigbe, K.O.; Oladejo, Eyitayo; Emikpe, Benjamin Obukowho; Asuk, Atamgba Agbor; Olaleye, Samuel Babafemi

doi:10.4318/tjg.2012.0423

Cited by 13 publications

(15 citation statements)

References 36 publications

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“…It was reported that the oxidative stress in gastric tissue causes damage to key biomolecules such as lipids. In conjunction with the report of [64][65][66], the present study recorded elevations in the levels of the end products of lipid peroxidation, malondialdehyde (MDA) in the gastric tissues following SGU. The elevation in MDA suggests enhanced lipid peroxidation leading to tissue damage and failure of antioxidant defense mechanisms to prevent the formation of excessive free radicals.…”

Section: Discussionsupporting

confidence: 80%

Antiulcerogenic Efficacy of Ethanolic Extract of Vitis Vinifera Leaves in Rats

Sayed

Fahmy

Soliman

et al. 2016

Int J Pharm Pharm Sci

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Objective: The ethanolic extract of Vitis vinifera leaves (VVE) (500 mg/kg body weight), ranitidine (50 mg/kg body weight) and both of them were tested for their gastroprotective and curative effects against the incidence of peptic ulcer. Methods:The antiulcer effects of VVE were investigated using a combination of indomethacin and cold-stress for 2h. To ascertain the mechanism of action of VVE, its protective and curative effects were studied on gastric volume, gastric juice acidity, ulcer index and malondialdehyde (MDA), glutathione (GSH), catalase (CAT), glutathione-S-transferase (GST), superoxide dismutase (SOD), nitric oxide (NO) activities of both stomach and duodenum of rats. Moreover, histopathological effects on stomach and duodenum were determined. Results:The antioxidant activity of VVE was demonstrated using 2, 2-diphenyl-1-picrylhydrazyl (DPPH) test. VVE was found to reduce the ulcer index, gastric volume and the level of gastric juice acidity. Also, VVE showed gastroprotective and curative activities mainly through improvement of antioxidant status and decreasing lipid peroxidation accompanied with amelioration of both stomach and duodenum architectures. Conclusion:The prophylactic and curative effects of VVE proved to be effective in preventing gastric and duodenal ulceration which may be probably due to its antioxidant and anti-acid secretory effects.

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Section: Discussionsupporting

confidence: 80%

Antiulcerogenic Efficacy of Ethanolic Extract of Vitis Vinifera Leaves in Rats

Sayed

Fahmy

Soliman

et al. 2016

Int J Pharm Pharm Sci

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“…and the ligation of the pylorus, induced histological lesions in mucosal and submucosal regions as revealed by histological examinations compared to control group (Figure 4). This finding conforms to that of several studies in which ulcer was induced using indomethacin [8,70,71] . …”

Section: Histopathological Studiessupporting

confidence: 92%

ANTIULCER ACTIVITY OF Musa paradisiaca (BANANA) TEPAL AND SKIN EXTRACTS IN ULCER INDUCED ALBINO MICE

Ahmad¹

2016

MJAS

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The current use of ulcer drugs is limited due to its side effects and potentiality of relapse. This study aimed to ascertain the antiulcer potentials of the tepal and skin extracts of banana Musa paradisiaca. The parts were processed and extracted using methanol by maceration. Phytochemicals content of both parts were screened. Twenty-five albino mice were used in in vivo analysis. The mice were treated with 100 mg/kg of tepal and skin extract as well as cimetidine for seven days followed by administration of indomethacin. The animals were sacrificed, and the removed stomachs were prepared for the evaluation of ulcer index and gastric wall mucus. pH and volume were measured from the gastric juice. The results revealed that banana's tepal and skin extracts contain phytochemicals like phenols, flavonoids and etc. The tepal and skin extracts prevented the IND+PYL induced ulcer by 68.80 ± 20.53% and 43.22 ± 14.82% respectively. Significant rise (p <0.05) in gastric juice pH (3.79 ± 0.24) was noticed in the banana's tepal treated group. However, the decrease in gastric juice volume and increased gastric wall mucus by both tepal and skin were not statistically significant (p >0.05). Findings from this study shows that banana's tepal and skin were able to prevent IND+PYL induced ulcer by strengthening the gastric mucosa and decreasing the gastric juice acidity.Keywords: banana's tepal, banana's skin, indomethacin, Musa paradisiaca, preventive index Abstrak Penggunaan ubat ulser pada masa kini adalah terhad disebabkan kesan sampingan dan potensi kambuh. Kajian ini bertujuan menentukan potensi antiulser dari ekstrak jantung dan kulit pisang Musa paradisiaca. Bahagian -bahagian ini telah diproses dan diekstrak menggunakan metanol melalui kaedah rendaman. Kandungan fitokimia kedua -dua bahagian telah disaring. Dua puluh lima tikus albino telah digunakan dalam analisis in vivo. Tikus -tikus ini telah diberi rawatan dengan 100mg/kg ekstrak jantung dan kulit pisang serta simetidin selama tujuh hari di ikuti dengan rawatan dengan indomethacin. Haiwan dikorbankan selepas 8 hari rawatan, dan perut dikeluarkan bagi penilaian indeks ulser dan mukus dinding perut. pH dan jumlah jus gastrik juga diukur. Hasil kajian mendapati bahawa ekstrak jantung dan kulit pisang mengandungi beberapa fitokimia seperti fenol, flavonoid, dan lain -lain. Ekstrak jantung dan kulit ini menghalang ulser yang diaruh dengan IND+PYL masing -masing sebanyak 68.80 ± 20.53% dan 43.22 ± 14.82%. Peningkatan yang signifikan (p <0.05) pada pH jus gastrik (3.79 ± 0.24) telah diperhatikan dalam kumpulan yang dirawat dirawat dengan jantung pisang. Walau bagaimanapun, penurunan dalam jumlah jus gastrik dan meningkatkan mukus dinding perut oleh kedua -dua ekstrak adalah tidak signifikan secara statistik (p >0.05). Dapatan dari kajian ini menunjukkan bahawa jantung dan kulit pisang dapat mencegah ulser yang diaruh dengan IND+PYL melalui penambahan mukosa perut dan pengurangan keasidan jus gastrik.

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“…On the 15th-day of pretreatment or vehicle administration and after 36 hours of starvation, rats were anesthetized with ether inhalation, carefully dissected, and exposed to pyloric-ligation [43] for gastric juice collection. After that, indomethacin (25 mg/kg) [44,45] was injected intra-peritoneally, excluding the normal control group which received a single intra-peritoneal injection of 1% saline solution with Tween 80 (vehicle of indomethacin). After 4 h, rats were killed by cervical dislocation under ether anesthesia.…”

Section: Methodsmentioning

confidence: 99%

Gastro-Protective and Anti-Oxidant Potential of Althaea officinalis and Solanum nigrum on Pyloric Ligation/Indomethacin-Induced Ulceration in Rats

et al. 2019

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Recently, an alternative disease treatment approach is the research of medicaments from traditional medicine. Plants with anti-oxidant capabilities are used as herbal treatments for ulcer diseases. Medicinal/herbal extracts containing phytoconstituents have significant anti-ulcer activities in in vivo experiments on animal models, compared to reference drugs. The current study aims to inspect gastro-protective as well as in vitro and in vivo anti-oxidant potential of Althaea officinalis and Solanum nigrum extracts on pyloric-ligation/indomethacin-induced gastric-ulceration in rats. Rats were divided into six groups: normal control, gastric ulcer control, two standard pretreatment groups receiving omeprazole and misoprostol, and two test pretreatment groups receiving Althaea officinalis and Solanum nigrum. Pretreatments were administrated orally for 14 days. On the 15th day, animals, excluding the normal control group, were exposed to pyloric-ligation followed by indomethacin injection. After four hours, the rat’s stomachs were removed and gastric juice and blood samples were collected. Pyloric-ligation/indomethacin administration caused considerable elevation in ulcer number, ulcer index, acid and pepsin productivity, aggressive factors, and gastric mucosal lipid-peroxide contents. Moreover, reduction in titratable acidity, gastric mucosal nitric-oxide, anti-oxidant contents, and protective factors accompanied gastric-ulceration. Additionally, elevation in pro-inflammatory cytokines content and reduction in cystathionine-β-synthase and heme-oxygenase-1 expression was witnessed. Omeprazole, misoprostol, Althaea officinalis, and Solanum nigrum pretreatments fixed blood and tissue biomarkers, thereby protecting them from pyloric-ligation/indomethacin-induced gastric-ulceration in rats, which is hopeful for clinical examinations.

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The dual modulatory effect of folic acid supplementation on indomethacin- induced gastropathy in the rat

Abstract: Girifl ve

Cited by 13 publications

References 36 publications

Antiulcerogenic Efficacy of Ethanolic Extract of Vitis Vinifera Leaves in Rats

Antiulcerogenic Efficacy of Ethanolic Extract of Vitis Vinifera Leaves in Rats

ANTIULCER ACTIVITY OF Musa paradisiaca (BANANA) TEPAL AND SKIN EXTRACTS IN ULCER INDUCED ALBINO MICE

Gastro-Protective and Anti-Oxidant Potential of Althaea officinalis and Solanum nigrum on Pyloric Ligation/Indomethacin-Induced Ulceration in Rats

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