The dual role of microRNA-9 in gastrointestinal cancers: oncomiR or tumor suppressor?

Bahrami, Afsane; Jafari, Amirsajad; Ferns, Gordon A.

doi:10.1016/j.biopha.2021.112394

Cited by 15 publications

(12 citation statements)

References 120 publications

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“…miRNAs are small non-coding RNAs of ~22 nt, which can be found in animals, plants, and some viruses regulating the expression of an enormous number of genes [ 15 ]. Their expressional profiles are distinct in different tissues [ 16 ]. Most miRNAs can be transcribed by RNA polymerase II or III, generating primary precursor miRNAs (pri-miRNAs) [ 17 ], which can be processed through the canonical or non-canonical pathways [ 18 ].…”

Section: Micrornas (Mirnas)mentioning

confidence: 99%

“…miRNA clusters can be transcribed polycistronically, which allows the coordinated regulation of complex biological processes and functional redundancy in some cases [ 18 ]. Generally, miRNAs bind the 3′-(UTR) untranslated region of messenger RNA (mRNA) to suppress expression [ 15 ], but they can also bind to the 5′-UTR region of mRNA to stimulate gene expression [ 16 ]. miRNAs perform their functions mainly in the cytoplasm; however, miRNAs also can be localized in other compartments such as the nucleus, mitochondria, endoplasmic reticulum, and Golgi apparatus [ 18 ].…”

Section: Micrornas (Mirnas)mentioning

confidence: 99%

“…However, aberrant expressions of miRNAs in human cancers have been widely reported. Different miRNAs have been implicated in cancer progression, proliferation, metastasis, angiogenesis, tumor-associated inflammation, modulation of the tumor microenvironment, and the response of tumor cells to chemotherapy [ 15 , 16 ].…”

Section: Micrornas (Mirnas)mentioning

confidence: 99%

“…On the other hand, oncomiRs have higher expression in tumors and inhibit the expression of target tumor-suppressor genes [ 19 ]. However, the functions of particular miRNAs in cancer can become more complex, presenting dual functions [ 16 ].…”

Section: Micrornas (Mirnas)mentioning

confidence: 99%

“…miRNAs have been detected in different bodily fluids, which suggests significant potential, such as their use as biomarkers in diagnostics and prognostics. Additionally, these versatile regulatory molecules could be used in therapeutic applications, although this potential will be explored and determined in future studies [ 16 , 21 ].…”

Section: Micrornas (Mirnas)mentioning

confidence: 99%

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Roles of microRNAs and Long Non-Coding RNAs Encoded by Parasitic Helminths in Human Carcinogenesis

Leija-Montoya

González-Ramírez

Martínez-Coronilla

et al. 2022

IJMS

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Infectious agents such as viruses, bacteria, and parasites can lead to cancer development. Infection with the helminthic parasite Schistosoma haematobium can cause cancer of the urinary bladder in humans, and infection with the parasites Clonorchis sinensis and Opisthorchis viverrini can promote cholangiocarcinoma. These three pathogens have been categorized as “group 1: carcinogenic to humans” by the International Agency for Research on Cancer (IARC). Additionally, the parasite Schistosoma japonicum has been associated with liver and colorectal cancer and classified as “group 2B: possibly carcinogenic to humans”. These parasites express regulatory non-coding RNAs as microRNAs (miRNAs) and long non-coding RNAs (lncRNAs), which modulate genic expression in different biological processes. In this review, we discuss the potential roles of miRNAS and lncRNAs encoded by helminthic parasites that are classified by the IARC as carcinogenic and possibly carcinogenic to humans. The miRNAs of these parasites may be involved in carcinogenesis by modulating the biological functions of the pathogen and the host and by altering microenvironments prone to tumor growth. miRNAs were identified in different host fluids. Additionally, some miRNAs showed direct antitumoral effects. Together, these miRNAs show potential for use in future therapeutic and diagnostic applications. LncRNAs have been less studied in these parasites, and their biological effects in the parasite–host interaction are largely unknown.

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Section: Micrornas (Mirnas)mentioning

confidence: 99%

Section: Micrornas (Mirnas)mentioning

confidence: 99%

Section: Micrornas (Mirnas)mentioning

confidence: 99%

Section: Micrornas (Mirnas)mentioning

confidence: 99%

Section: Micrornas (Mirnas)mentioning

confidence: 99%

See 3 more Smart Citations

Roles of microRNAs and Long Non-Coding RNAs Encoded by Parasitic Helminths in Human Carcinogenesis

Leija-Montoya

González-Ramírez

Martínez-Coronilla

et al. 2022

IJMS

View full text Add to dashboard Cite

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Harnessing the therapeutic potential of phytochemicals in neuroblastoma

Ahmadi,

Bagherzadeh,

Sargazi

et al. 2024

BioFactors

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Neuroblastomas are the most common solid tumors outside of the brain that originate from immature neural crest cells, accounting for about 10% of all pediatric malignancies. The treatment for neuroblastomas involves a multimodal schedule, including surgery, radiation, chemotherapy, and immunotherapy. All these modalities are limited by side effects that might be severe, poor prognosis, and a high risk of recurrence. In the quest for additional therapeutic approaches, phytochemicals have attracted attention owing to their reported antitumor properties, safety, and multimechanistic mode of action. Several studies have used plant‐derived bioactive compounds such as phenolics and flavonoids, suggesting modulation of biomolecules and signal transduction pathways involved in neuroblastoma. We reviewed the findings of recent preclinical and clinical studies demonstrating the effects of phytochemicals on neuroblastoma, shedding light on their molecular mechanism of action and potential therapeutic applications.

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