The employment difficulty of modern college students has become one of the common problems in the society, and the diversified employment model of entrepreneurship as employment pull has become an effective way to enhance the employment rate and boost the social and economic development. The innovative and venture education into the whole procedure of talent training has become a new education concept and reached a consensus. However, this mode of education is not immutable. Under the background of major social events and emergent social problems, creation and entrepreneurship education is faced with the challenge of mechanism and way. The research perspective of this paper is based on the multiple psychological and operational crises brought to entrepreneurs and entrepreneurs by industrial structure contradictions and marketing mode changes in the social environment of COVID-19 public events. How to turn the crisis into a business opportunity through flexible and diversified innovation education and entrepreneurship support, and better accomplish the task of creation and entrepreneurship by changing creation and entrepreneurship education and practice in various turbulent situations? Under the background of COVID-19 epidemic, this paper proposes solutions to problems existing in the practice of contemporary college students, and discusses new modes of creation and entrepreneurship for academy students.