The dynamics of magnetic nanoparticles exposed to non-heating alternating magnetic field in biochemical applications: theoretical study

Golovin, Yuri I.; Gribanovsky, Sergey L.; Golovin, D. Yu.; Zhigachev, Andrey O.; Klyachko, Natalia L.; Majouga, Alexander G.; Sokolsky-Papkov, Marina; Kabanov, Alexander V.

doi:10.1007/s11051-017-3753-6

Cited by 26 publications

(25 citation statements)

References 68 publications

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“…MNs exhibiting tunable magnetic and surface properties are ideal platforms to generate forces, target certain mechanosensitive proteins, and allow for noninvasive control within biological systems. Recent studies have proposed MN‐based mechanotransduction as a mechanogenetic strategy to investigate and stimulate mechanosensitive proteins and signaling pathways . Here, we provide recent examples on cell fate regulation for stem‐cell‐based regenerative medicine, other types of somatic cells, and cancer treatment.…”

Section: Mn‐based Mechanotransduction For Cell Fate Regulationmentioning

confidence: 99%

“…Generating mechanical force is the key feature of MNs for mechanotransduction. As a magnetic field signaling receiver and convertor, MNs can transform the external energy of the magnetic field into mechanical energy . It has been estimated that manipulation of mechanical sensitive biomolecules requires the force in the range of piconewtons .…”

Section: Mn‐based Mechanotransduction For Cell Fate Regulationmentioning

confidence: 99%

“…Therefore, specific MNs have been developed as mechanotransduction tools to modulate cell fate . The design of these MNs offers maneuverability under an external magnetic field through their fine‐tuned compositions and geometries to generate localized forces on cells . After tethering with specific biomolecules, MNs can exert forces on targeted cellular compartments and subsequently manipulate mechanical microenvironments.…”

Section: Introductionmentioning

confidence: 99%

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Recent Advances in Magnetic‐Nanomaterial‐Based Mechanotransduction for Cell Fate Regulation

Shen

Chen

et al. 2018

Advanced Materials

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Remote control of cells and the regulation of cell events at the molecular level are of great interest in the biomedical field. In addition to chemical compounds and genes, mechanical forces play a pivotal role in regulating cell fate, which have prompted the rapid growth of mechanobiology. From a perspective of nanotechnology, magnetic nanomaterials (MNs) are an appealing option for mechanotransduction due to their capabilities in spatiotemporal manipulation of mechanical forces via the magnetic field. As a newly developed paradigm, magneto-mechanotransduction is harnessed to physically regulate cell fate for biomedical applications. Here, the critical factors that determine the magnetomechanical forces induced by MNs in mechanotransduction are briefly reviewed. Recent innovative approaches and their underlying mechanisms for controlling cell fate are highlighted, which offer possibilities for the remote mechanical manipulation of cells and biomolecules in a precise manner. Promising applications including regenerative medicine and cancer treatment based on magnetomechanical stimulation through MNs are also addressed. Perspectives and challenges in MN-based mechanotransduction are commented.

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Section: Mn‐based Mechanotransduction For Cell Fate Regulationmentioning

confidence: 99%

Section: Mn‐based Mechanotransduction For Cell Fate Regulationmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

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Recent Advances in Magnetic‐Nanomaterial‐Based Mechanotransduction for Cell Fate Regulation

Shen

Chen

et al. 2018

Advanced Materials

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“…Для эффективного и безопасного применения NMMA как средства терапии необходимо: а) знать наномеханические свойства всех целевых наномолекулярных структур и их возможные биофизические и биохимические отклики на силы и деформации; б) уметь дистанционно создавать и контролировать эти воздействия с молекулярной локальностью и селективностью. Как решаются эти сложные междисциплинарные задачи, в которых изучение наномеханических характеристик биомолекулярных структур занимает центральное место, описано в обзорах [273][274][275]. Из представленных в них материалов следует, что NMMA является еще одним, пока недостаточно изученным, но не менее мощным и универсальным способом воздействия на биомолекулы, клетки, ткани наравне с нагревом, химическим или радиационным воздействием.…”

Section: разрушение в микро- субмикрои наношкалеunclassified

Наноиндентирование И Механические Свойства Материалов В Субмикро- И Наношкале. Недавние Результаты И Достижения (О Б З О Р)

Головин¹

2021

Физика Твердого Тела

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The review discusses the details of various materials mechanical behavior in submicro- and nanoscale. Significant advances in this scope result from the development of wide family of load based precise nanotesting techniques called nanoindentation. But nowadays, nanomechanical properties are studied not only by nanoindentation techniques in narrow sense, i.e. local loading of macro, micro and nanoscale objects. Nanomechanical load testing is discussed here within a wider scope employing precise deformation measurement with nanometer scale resolution caused by various types of low load application to the object under study including uniaxial compression or extension, shearing, bending or twisting, optionally accompanied by in situ monitoring sample microstructure using scanning and transmission electron microscopy and Laue microdiffraction technique. The main courses of experimental techniques development in recent ten years along with the results obtained using them in single, poly and nano crystalline materials, composites, films and coatings, amorphous solids and such biomaterials as tissues, living cells and macromolecules are described. Special attention is paid to deformation size effects and atomic mechanisms in nanoscale. This review is a natural continuation and development of the review published at Fiz.Tverd.Tela vol.50, issue 12, 2008 of the same author that discusses details of nanomechanical properties of solids. Current review includes wider range of nanomechanical testing concepts and recent achievements in the scope. The work was supported by RFBR grant for project #19-12-50235.

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“…As nanoscale magnetic field signal receivers and convertors, MIONs can transform the external electromagnetic energy into mechanical energy . It has been reported that manipulation of mechanically sensitive biomolecules needs a force in the range of piconewtons (pN) .…”

Section: Fundamentals Of Mionsmentioning

confidence: 99%

Magnetic Nanomaterials for Advanced Regenerative Medicine: The Promise and Challenges

et al. 2018

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The recent emergence of numerous nanotechnologies is expected to facilitate the development of regenerative medicine, which is a tissue regeneration technique based on the replacement/repair of diseased tissue or organs to restore the function of lost, damaged, and aging cells in the human body. In particular, the unique magnetic properties and specific dimensions of magnetic nanomaterials make them promising innovative components capable of significantly advancing the field of tissue regeneration. Their potential applications in tissue regeneration are the focus here, beginning with the fundamentals of magnetic nanomaterials. How nanomaterials—both those that are intrinsically magnetic and those that respond to an externally applied magnetic field—can enhance the efficiency of tissue regeneration is also described. Applications including magnetically controlled cargo delivery and release, real‐time visualization and tracking of transplanted cells, magnetic regulation of cell proliferation/differentiation, and magnetic activation of targeted ion channels and signal pathways involved in regeneration are highlighted, and comments on the perspectives and challenges in magnetic nanomaterial‐based tissue regeneration are given.

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The dynamics of magnetic nanoparticles exposed to non-heating alternating magnetic field in biochemical applications: theoretical study

Cited by 26 publications

References 68 publications

Recent Advances in Magnetic‐Nanomaterial‐Based Mechanotransduction for Cell Fate Regulation

Recent Advances in Magnetic‐Nanomaterial‐Based Mechanotransduction for Cell Fate Regulation

Наноиндентирование И Механические Свойства Материалов В Субмикро- И Наношкале. Недавние Результаты И Достижения (О Б З О Р)

Magnetic Nanomaterials for Advanced Regenerative Medicine: The Promise and Challenges

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