The E3 ligase subunit FBXO45 binds the interferon-λ receptor and promotes its degradation during influenza virus infection

Tsai, Ming‐June; Osman, Wissam; Adair, J.; ElMergawy, Rabab; Chafin, Lexie; Farkas, Daniela; Elhance, Ajit; Londino, J.D.; Mallampalli, Rama K.

doi:10.1016/j.jbc.2022.102698

Cited by 4 publications

(2 citation statements)

References 56 publications

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“…They have shown that influenza viral infection induced the expression of FBXO45, which in turn mediated polyubiquitination of IFNLR1, followed by proteasome-dependent degradation of this protein, resulting in an impaired type III IFN signaling. Further, the Lysine319 and Lysine320 of IFNLR1 were shown to be important for the virus-induced ubiquitination of IFNLR1 [73].…”

Section: Viral Degradation Of the Cellular Factors In The Type II And...mentioning

confidence: 94%

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Triggering Degradation of Host Cellular Proteins for Robust Propagation of Influenza Viruses

Xia,

Wang,

Hahm

2024

IJMS

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Following infection, influenza viruses strive to establish a new host cellular environment optimized for efficient viral replication and propagation. Influenza viruses use or hijack numerous host factors and machinery not only to fulfill their own replication process but also to constantly evade the host’s antiviral and immune response. For this purpose, influenza viruses appear to have formulated diverse strategies to manipulate the host proteins or signaling pathways. One of the most effective tactics is to specifically induce the degradation of the cellular proteins that are detrimental to the virus life cycle. Here, we summarize the cellular factors that are deemed to have been purposefully degraded by influenza virus infection. The focus is laid on the mechanisms for the protein ubiquitination and degradation in association with facilitated viral amplification. The fate of influenza viral infection of hosts is heavily reliant on the outcomes of the interplay between the virus and the host antiviral immunity. Understanding the processes of how influenza viruses instigate the protein destruction pathways could provide a foundation for the development of advanced therapeutics to target host proteins and conquer influenza.

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Section: Viral Degradation Of the Cellular Factors In The Type II And...mentioning

confidence: 94%

“…As for the type III IFN system, MuChun Tsai et al have demonstrated that the receptor subunit IFNLR1 in human airway epithelia was rapidly degraded during influenza virus infection [73]. They have also identified the E3 ligase of IFNLR1, which is the Skp-Cullin-F ligase subunit FBXO45.…”

Section: Viral Degradation Of the Cellular Factors In The Type II And...mentioning

confidence: 99%

Triggering Degradation of Host Cellular Proteins for Robust Propagation of Influenza Viruses

Xia,

Wang,

Hahm

2024

IJMS

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Expression and function of interferon lambda receptor 1 variants

Novotny,

Meissner

2024

FEBS Letters

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Lambda interferons (IFNLs) provide critical host defense against pathogens encountered at mucosal surfaces. In humans, IFNL signaling is regulated in part by low and cell‐type restricted expression of the lambda interferon receptor 1 protein with expression restricted primarily to epithelial cells located at mucosal surfaces. This review will examine the evidence suggesting a role for IFNLR1 transcriptional variants in mediating cell responsiveness to IFNL ligand exposure and regulation of pathway activity.

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Targeting the Ubiquitin Proteasome System to Combat Influenza A Virus: Hijacking the Cleanup Crew

Anang,

Antonescu,

Nho

et al. 2024

Reviews in Medical Virology

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Influenza A virus (IAV) remains a significant global public health threat, causing substantial illness and economic burden. Despite existing antiviral drugs, the emergence of resistant strains necessitates alternative therapeutic strategies. This review explores the complex interplay between the ubiquitin proteasome system (UPS) and IAV pathogenesis. We discuss how IAV manipulates the UPS to promote its lifecycle, while also highlighting how host cells utilise the UPS to counteract viral infection. Recent research on deubiquitinases as potential regulators of IAV infection is also addressed. By elucidating the multifaceted role of the UPS in IAV pathogenesis, this review aims to identify potential targets for novel therapeutic interventions.

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The E3 ligase subunit FBXO45 binds the interferon-λ receptor and promotes its degradation during influenza virus infection

Cited by 4 publications

References 56 publications

Triggering Degradation of Host Cellular Proteins for Robust Propagation of Influenza Viruses

Triggering Degradation of Host Cellular Proteins for Robust Propagation of Influenza Viruses

Expression and function of interferon lambda receptor 1 variants

Targeting the Ubiquitin Proteasome System to Combat Influenza A Virus: Hijacking the Cleanup Crew

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