The Early Diagnosis of Primary Lung Cancer by Cytologic Methods

Farber, Seymour M.; McGRATH, Allen K.; Benioff, Mortimer A.; Espen, Lloyd W.

doi:10.1378/chest.20.3.237

Cited by 24 publications

(2 citation statements)

References 12 publications

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“…When multiple sputum specimens are examined, the accuracy of sputum cytology increases. Färber 13 has reported a 90% accuracy in the diagnosis of lung cancer when five or more sputum specimens were examined. The efficiency of this cytologic method has been attested by many investigators, with the accuracy of diagnosis ranging from 75 to 90 per cent in various pub lished series.…”

Section: Commentmentioning

confidence: 99%

L The Diagnosis of Bronchogenic Carcinoma

Wolfson¹

1961

Ann Otol Rhinol Laryngol

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Multiple diagnostic procedures are available for the investigation of patients with suspected bronchogenic carcinoma. The importance of bronchoscopic biopsy, anterior scalene lymph node biopsy, and needle biopsy of the lung has been well documented. More recently the cytologic examination of sputum, aspirated bronchial secretions, and pleural fluid has been found to be of practical value and is now widely used in the investigation of pulmonary lesions.The purpose of this study was to determine the diagnostic accu racy and relative sensitivity of each of the diagnostic procedures used to establish the presence of bronchogenic carcinoma in a series of 482 proven cases. METHOD AND MATERIALBetween the period of 1951 to 1959, 482 patients were seen at the Temple University Medical Center where a histologic diagnosis of bronchogenic carcinoma was made. Patients with clinical evidence of lung cancer, but not confirmed histologically were excluded from this study. Also excluded were cases which were diagnosed prior to entering this hospital.A bronchoscopic examination was performed at the Chevalier Jackson Clinic on 454 patients in this series. All bronchoscopies were performed under local anesthesia. Telescopic visualization of the tracheobronchial tree was routinely used.In 376 cases, secretions were aspirated during the bronchoscopy and sent for cytologic study. Each specimen of secretion was smeared on four slides and prepared by the usual Papanicolaou technique for the cytologic examination.

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Section: Commentmentioning

confidence: 99%

L The Diagnosis of Bronchogenic Carcinoma

Wolfson¹

1961

Ann Otol Rhinol Laryngol

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“…They estimated their accuracy at 50% on sputum samples, with a 10% increase in accuracy if bronchial washings were also examined. Färber and his group5 reported an over-all accuracy of 55% in 241 cases of proved bronchogenic carcinoma, with the accuracy increased to 90% if five or more specimens were examined. Papanicolaou's6 cases revealed an over-all accuracy of 94.5% in 54 patients studied.…”

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confidence: 99%