This study aimed to find out the influence of university role in the implementation of eco-innovation in the creative industry in the natural stone handicraft sector. The object of this research was the creative industry center of the marble and natural stone handicraft sub-sector in Tulungagung City, Indonesia. From the existing craftsmen population, 81 craftsmen as respondents were taken as samples. The research data was obtained by distributing questionnaires, then the data were tested, processed, and analyzed using Partial Least Square Consistent-Structural Equation Modeling (PLSc-SEM). The results of this study stated that university's role in the implementation of eco-innovation in the industry center of natural stone handicraft in Tulungagung could significantly improve eco-organizational innovation, eco-process innovation, and eco-marketing innovation. However, it was not significant in improving eco-product innovation. In order to further improve the implementation of eco-product innovation, the university role in assisting to increase eco-marketing needed to improve because of its significant influence on eco-product innovation. Later, the results of the study were developed to explain the concept of triple helix, namely the role of university, industry, and government in the implementation of eco-innovation and the performance improvement of creative industrial centers of natural stone crafts in Tulungagung Indonesia.