The article presents an analysis of tools for influencing the sustainable development of regions, considering their industry specifics, as well as ways to influence socioeconomic growth. The purpose of the article is to model the assessment of demoetic, demographic, democratic, and demoeconomical factors as the basis of the industrial and innovative paradigm of social sustainability. Achieving sustainability is possible only along the vector of harmony through the systemic combination 4D = “D + 3D”, namely, demoethics and demography, democracy, demoeconomy. Analysis of the existing processes of development and harmonization of society is implemented in the example of Kazakhstan. Research methods include integral analysis for ranking regions and correlation and regression modeling to assess the impact of factors on the process of sustainable development of society in a particular territory. The article hypothesizes that the creation of conditions for the development of the main regional industry will stimulate its sustainable and harmonious socioeconomic growth and provide the necessary level for the process of social harmonization. The findings show that the proposed approach made it possible to identify harmonious and disharmonious factors in the development of the region and to identify tools for influencing the process of sustainable development of society to increase the level of harmonious socioeconomic development of a particular region.