The Edwin Smith papyrus: a clinical reappraisal of the oldest known document on spinal injuries

Middendorp, Joost J. van; Sanchez, Gonzalo M.; Burridge, Alwyn Louise

doi:10.1007/s00586-010-1523-6

Cited by 103 publications

(43 citation statements)

References 23 publications

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“…(van Middendorp et al, 2010). However, it is only since the latter half of the past century that ways to counteract the effects of spinal cord injury have been subjected to systematic studies in experimental animals (see Box 1).…”

Section: Introductionmentioning

confidence: 99%

Rat models of spinal cord injury: from pathology to potential therapies

Kjell

Olson

2016

Disease Models &Amp; Mechanisms

309

209

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A long-standing goal of spinal cord injury research is to develop effective spinal cord repair strategies for the clinic. Rat models of spinal cord injury provide an important mammalian model in which to evaluate treatment strategies and to understand the pathological basis of spinal cord injuries. These models have facilitated the development of robust tests for assessing the recovery of locomotor and sensory functions. Rat models have also allowed us to understand how neuronal circuitry changes following spinal cord injury and how recovery could be promoted by enhancing spontaneous regenerative mechanisms and by counteracting intrinsic inhibitory factors. Rat studies have also revealed possible routes to rescuing circuitry and cells in the acute stage of injury. Spatiotemporal and functional studies in these models highlight the therapeutic potential of manipulating inflammation, scarring and myelination. In addition, potential replacement therapies for spinal cord injury, including grafts and bridges, stem primarily from rat studies. Here, we discuss advantages and disadvantages of rat experimental spinal cord injury models and summarize knowledge gained from these models. We also discuss how an emerging understanding of different forms of injury, their pathology and degree of recovery has inspired numerous treatment strategies, some of which have led to clinical trials.

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Section: Introductionmentioning

confidence: 99%

Rat models of spinal cord injury: from pathology to potential therapies

Kjell

Olson

2016

Disease Models &Amp; Mechanisms

309

209

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“…31). It has been suggested that the cases described in the papyrus predominantly concern patients who sustained their injuries during battles or construction work [19] . Ancient Egyptian surgeons classified spinal cord injuries into three broad categories: 1 An ailment that I will treat (favorable cases).…”

Section: Spinal Cord Injurymentioning

confidence: 99%

Neurology and War: From Antiquity to Modern Times

Paciaroni¹,

Arnao²

2016

War Neurology

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Here, we chronicle the evolution of warfare from antiquity to modern times (18th century) and its impact on the later-to-be-defined field of neurology, especially with regard to brain, spinal cord and peripheral nerve injuries and neurological disorders caused by biological weapons and psychological trauma. We describe how individuals courageously and intelligently dealt with the horrors of war, from the Egyptians to the Greeks and onward to the Romans, up until the physicians of modern times. In doing so, they responded to the call of duty by inventing solutions that benefitted not only soldiers but also civilian medicine.

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“…Historically, thoracic injuries to the spine have always predominantly been treated non-operatively [14]. Right up to the present day, there are publications which contemplate conservative treatment even for unstable fractures with neurological signs and symptoms [15].…”

Section: Conservative Managementmentioning

confidence: 99%

Traumatic Fractures of the Thoracic Spine

et al. 2020

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The majority of traumatic vertebral fractures occur at the thoracolumbar junction and the lumbar spine and less commonly at the mid-thoracic and upper thoracic spine. In accordance, a high number of articles are dealing with thoracolumbar fractures focusing on the thoracolumbar junction. Nonetheless, the biomechanics of the thoracic spine differ from the thoracolumbar junction and the lumbar vertebral spine. The aim of this review is to screen the literature dealing with acute traumatic thoracic vertebral fractures in patients with normal bone quality. Thereby, the diagnostic of thoracic vertebral body fractures should include a CT examination. Ideally, the CT should include the whole thoracic cage particularly in patients suffering high energy accidents or in those with clinical suspicion of concomitant thoracic injuries. Generally, concomitant thoracic injuries are frequently seen in patients with thoracic spine fractures. Particularly sternal fractures cause an increase in fracture instability. In case of doubt, long segment stabilization is recommended in patients with unstable mid- und upper thoracic fractures, particularly in those patients with a high grade of instability.

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The Edwin Smith papyrus: a clinical reappraisal of the oldest known document on spinal injuries

Cited by 103 publications

References 23 publications

Rat models of spinal cord injury: from pathology to potential therapies

Rat models of spinal cord injury: from pathology to potential therapies

Neurology and War: From Antiquity to Modern Times

Traumatic Fractures of the Thoracic Spine

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