The effect in post-menopausal women of natural human and artificial oestrogens on the concentration in serum of prolactin

Andersen, Jesper Rye; Schroeder, Erik; Lebech, P. E.

doi:10.1530/acta.0.0950433

Cited by 20 publications

(8 citation statements)

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“…However, these agents also affect the growth hormone-IGF-I axis. ERT increases blood levels of growth hormone, and reduces blood levels of IGF-I (Andersen et al, 1980), and Tamoxifen reduces secretion of growth hormone (Malaab et al, 1992), and lowers blood levels of IGF-I, at least in postmenopausal women (Pollak et al, 1990).…”

Section: Discussionmentioning

confidence: 99%

The association of breast mitogens with mammographic densities

et al. 2002

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Radiologically dense breast tissue (mammographic density) is strongly associated with risk of breast cancer, but the biological basis for this association is unknown. In this study we have examined the association of circulating levels of hormones and growth factors with mammographic density. A total of 382 subjects, 193 premenopausal and 189 postmenopausal, without previous breast cancer or current hormone use, were selected in each of five categories of breast density from mammography units. Risk factor information, anthropometric measures, and blood samples were obtained, and oestradiol, progesterone, sex hormone binding globulin, growth hormone, insulin-like growth factor-I and its principal binding protein, and prolactin measured. Mammograms were digitised and measured using a computer-assisted method. After adjustment for other risk factors, we found in premenopausal women that serum insulin-like growth factor-I levels, and in postmenopausal women, serum levels of prolactin, were both significantly and positively associated with per cent density. Total oestradiol and progesterone levels were unrelated to per cent density in both groups. In postmenopausal women, free oestradiol (negatively), and sex hormone binding globulin (positively), were significantly related to per cent density. These data show an association between blood levels of breast mitogens and mammographic density, and suggest a biological basis for the associated risk of breast cancer.

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Section: Discussionmentioning

confidence: 99%

The association of breast mitogens with mammographic densities

et al. 2002

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“…Further, the consumption of glucose was determined in the media of period 2, 4 and 6 of study I. Prl was determined as described earlier (Andersen et al 1980) with the international standard 75/504 as re¬ ference. None of the media used affected the assay.…”

Section: Methodsmentioning

confidence: 99%

The effect of hyposmotic and sodium chloride hyperosmotic environments on the secretion and synthesis of prolactin from human decidua in vitro

Andersen

Borggaard

Ørnvold

et al. 1982

Acta Endocrinologica

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Using a paired design as well as a cross-over design both with 16 h incubation periods, we have incubated human decidua in hyposmotic, isosmotic, and sodium chloride hyperosmotic media. In the cross-over design each tissue aliquot was subjected to 3 media with different osmolalities, one of which was isosmotic. Thus, intensive utilization of the tissue was possible. The results of the cross-over study were identical with the result of the paired design. We found a decreased secretion of prolactin in hyposmotic environments, whereas hyperosmotic environments up to an osmolality about 400 mmol/kg gave a dose related increase in the prolactin secretion into the medium as well as in the total content of prolactin in the tissue and the medium. Excessive hyperosmotic medium decreased the secretion.The enhanced secretion was an effect of increased production, which could be blocked by cycloheximide. We found no feedback of prolactin on its own secretion.

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“…Levels of sex hormones in the blood, particularly estrogen, progesterone, and prolactin, may also play a role in the etiology of mammographic densities. Blood levels of prolactin, for example, are reduced by pregnancy and menopause [39,40] and increased by HRT [41], all variables with effects on mammographic densities.…”

Section: Discussionmentioning

confidence: 99%

Mammographic densities as a marker of human breast cancer risk and their use in chemoprevention

et al. 2001

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Differences in the parenchymal pattern of the breast on mammography reflect differences in the amounts of stromal, epithelial, and fat tissue present in the breast. Stroma and epithelium are radiologically dense, whereas fat is lucent. Extensive areas of mammographically dense breast tissue are strongly associated with an increased risk of breast cancer. A variety of interventions, including gonadotropin-releasing hormone inhibitor, tamoxifen, stopping hormone replacement therapy (HRT), and adopting a low-fat, high-carbohydrate diet, all influence the tissue composition of the breast and reduce mammographic densities. Of the interventions examined to date, only tamoxifen has been shown to reduce the incidence of breast cancer, at least in the short term. Conversely, HRT, which increases density, also increases risk of breast cancer. These results suggest that mammographic density may be a short-term marker of the effect on the breast of potential preventive interventions for breast cancer.

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The effect in post-menopausal women of natural human and artificial oestrogens on the concentration in serum of prolactin

Cited by 20 publications

References 9 publications

The association of breast mitogens with mammographic densities

The association of breast mitogens with mammographic densities

The effect of hyposmotic and sodium chloride hyperosmotic environments on the secretion and synthesis of prolactin from human decidua in vitro

Mammographic densities as a marker of human breast cancer risk and their use in chemoprevention

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