, MD2D0SSING M, LOFT S, SCHROEDER E. Jet fuel and liver function. Scand J Work Environ Health II (1985) 433-437. The impact of occupational exposure to jet fuel on antipyrineelimination wasstudied in 91 fuel-filling attendants. The mean antipyrine clearancewas enhancedto 68.4 (SD 19.5)ml/min during exposure to jet fuel compared to 57.9 (SD 18.1)ml/min after an exposure-free period of two to four weeks. The correspondingvalues for 47 office workers (referents) were 62.7 (SD 22.2) ml/min and 56.4 (SD 22.3) ml/min. The median jet fuel concentration in the breathing zone of the fuel-filling attendants was 31 (range I-I 020) mg/rn-. No known inducing factor could be identified in the work environment ofthe office workers. No difference in the concentration of aspartate aminotransferase and alkaline phosphatase in serum was found either within or between the groups. Our study indicates that jet fuel, which is a mixture of aliphatic and aromatic organic solvents resembling gasoline and white spirit, is an inducer of hepatic drug metabolism in man.

No abstract

The morphology of the healing process of microsurgical re-anastomosis of the rabbit oviduct with the use of fibrin adhesive, autologous and heterologous, and conventional sutures is described. Both oviducts in 48 rabbits were cut and reanastomoses were performed. The rabbits were killed at different intervals after the operations, ranging from 2 h to 28 days, and the anastomoses were evaluated by histomorphological examination.The autologous fibrin adhesive was absorbed after a week and an uncomplicated healing was observed. Heterologous fibrin adhesive caused a granulomatous inflammation interpreted as an immune reaction of the host to the foreign protein, and conventional suturing resulted in severe tissue damage with an intensive inflammatory reaction.

Microsurgical reconstruction of the rabbit oviduct was undertaken utilizing either: A: fibrin sealant in a thick layer applied to two or three serosa microsutures (20 rabbits), B: fibrin sealant only (20 rabbits), and C: microsutures only (20 rabbits). The pregnancy rates and the patency rates of the oviducts showed no significant differences between the three groups. However, the formation of adhesions at the site of reanastomosis was significantly lower and the total duration of surgery significantly shortened when fibrin sealant was employed. It is concluded that fibrin sealant combined with serosa microsutures certainly is the most convenient method in human tubal microsurgery seeing that this method maintains a higher tensil strength at the site of reanastomosis as compared to group B and avoid the risk of mucosal lesions as compared to group C.

25 women aged 53\ p=n-\ 78 years with at least two vears menopause were divided in three groups receiving one of the following oral treatments for three weeks: 2 mg oestradiol-17\g=b\plus 1 mg oestriol, 4 mg oestradiol\x=req-\ 17\g=b\plus 2 mg oestriol or 50 \ g=m\ gethinyloestradiol daily. Blood samples were collected before, during and after the treatment and the effect on the serum concentration of prolactin, oestradiol-17\g=b\,follicle-stimulating hormone and luteinizing hormone was evaluated. During treatment with natural human oestrogens serum oestradiol-17\g=b\ levels were significantly higher than before treatment. The serum concentration of prolactin was unchanged in patients receiving 2 mg oestradiol-17\g=b\ plus 1 mg oestriol but increased in patients receiving 4 mg oestradiol-17\g=b\plus 2 mg oestriol or 50 \ g=m\ gethinyloestradiol, thus indicating dose-dependence for natural human oestrogens. However, the increase was moderate, and these higher levels were not significantly different from levels of prolactin in serum found in 16 younger women. Concentrations of follicle-stimulating hormone and luteinizing hormon were depressed during treatment, the former to significantly lower levels when higher doses of oestrogens were used. During recent years, there have been several reports of a positive correlation between serum concentrations of oestrogens and prolactin1 in humans.