The effect of 12 weeks of aerobic training on serum levels high sensitivity C-reactive protein, tumor necrosis factor-alpha, lipid profile and anthropometric characteristics in middle-age women patients with type 2 diabetes

Saghebjoo, Marziyeh; Nezamdoost, Zeynab; Ahmadabadi, Fereshteh; Saffari, Iman; Hamidi, Azar

doi:10.1016/j.dsx.2017.12.008

Cited by 21 publications

(11 citation statements)

References 32 publications

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“…In the included 20 RCTs (n = 30 arms), the following three types of exercise were investigated: aerobic exercise (n = 17 arms), resistance exercise (n = 7 arms), and a combination of aerobic and resistance exercise (n = 6 arms). Of the 20 included studies, two studies investigated women (El-Kader & Al-Dahr, 2016; Saghebjoo et al, 2018), five studies investigated men (Annibalini et al, 2017; Cooper et al, 2016; Dadrass et al, 2019; Donges et al, 2013; Nikseresht et al, 2016), and others (Balducci et al, 2010; Donley et al, 2014; El-Kader et al, 2015; Jorge et al, 2011; Kadoglou et al, 2007, 2010; Levinger et al, 2009; Mora-Rodriguez et al, 2018; Sang et al, 2015; Slivovskaja et al, 2018; Stefanov et al, 2013; Swift et al, 2012; Venojärvi et al, 2013) studied both genders (Table 1).…”

Section: Resultsmentioning

confidence: 99%

“…Each of the MetS components could predispose individuals to cardiovascular diseases (CVD), and the risk increases when a number of these components together appear in one person (Attarzadeh Hosseini et al, 2017; Sang et al, 2015). For example, white adipose tissue as an active endocrine and paracrine organ expresses and secretes inflammatory adipokines, such as C-reactive protein (CRP), tumor necrosis factor-alpha (TNF-α), and interleukins (ILs; Golbidi & Laher, 2014; Nikseresht et al, 2016; Saghebjoo et al, 2018), which are identified as predictors of insulin resistance and CVD (Levinger et al, 2009). Moreover, traditionally CRP and recently IL-18 are seen as strong inflammatory markers for inflammation status (Stensvold et al, 2012).…”

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confidence: 99%

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Anti-Inflammatory Effects of Exercise on Metabolic Syndrome Patients: A Systematic Review and Meta-Analysis

Yousefabadi

Niyazi

Alaee

et al. 2020

Biological Research For Nursing

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Background: Increments in inflammatory indicators and low levels of physical activity are correlated to the expansion of the metabolic syndrome (MetS). Objective: The purpose of this study was to establish if exercise training ameliorates inflammatory status in MetS patients. Data sources: PubMed, CINAHL, and Medline, Google Scholar, and Scopus databases and reference lists of included studies were searched. Study selection: Twenty randomized controlled trials (RCTs) of exercise-training impact on inflammatory markers (tumor necrosis factor (TNF) α, C-reactive protein (CRP), interleukin (IL) 6, IL-8, IL-10, and IL-18) with concurrent control groups were included in this analysis. Results: Results demonstrated an overall significant decrease in serum levels of TNF-α (mean difference (MD): −1.21 pg/ml; 95% confidence interval (CI): −1.77, −0.66), CRP (MD: −0.52 mg/l; 95% CI: −0.79, −0.25), IL-8 (MD: −1.31 pg/ml; 95% CI: −2.57, −0.06), and a significant increase in IL-10 (MD: 0.48 pg/ml; 95% CI: 0.10, 0.86). But exercise training did not change the level of IL-6 (MD: −0.69 pg/ml; 95% CI: −1.53, 0.14) and IL-18 (MD: −53.01 pg/ml; 95% CI: −166.64, 60.62). Conclusion: Exercise training improves TNF-α, CRP, IL-8, and IL-10 levels in patients with MetS. For some variables, isolated aerobic exercise, and combined aerobic and resistance exercise appears to be optimal. Future research is needed to clarify the mechanisms underlying exercise training’s effect on this population’s inflammatory markers. More studies are required to confirm these findings.

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Section: Resultsmentioning

confidence: 99%

mentioning

confidence: 99%

Anti-Inflammatory Effects of Exercise on Metabolic Syndrome Patients: A Systematic Review and Meta-Analysis

Yousefabadi

Niyazi

Alaee

et al. 2020

Biological Research For Nursing

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“…In contrast to a previous report where CRP levels remained unaltered in response to a 4-month intradialytic exercise training intervention (cycling) [32], we observed a 15% reduction in hs-CRP in TR, in response to 6 months of exercise training. In fact, engaging in long-term cardiovascular exercise training, particularly of moderate intensity [60], is associated with a reduction in serum CRP levels both in healthy [61] and clinical populations [62,63], and is usually associated with reductions in body fat [61]. Accordingly, the reduction in hs-CRP levels observed in TR was accompanied by a 2% reduction in body fat percentage.…”

Section: Discussionmentioning

confidence: 99%

Intradialytic Cardiovascular Exercise Training Alters Redox Status, Reduces Inflammation and Improves Physical Performance in Patients with Chronic Kidney Disease

et al. 2020

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Redox status (RS) perturbations and inflammation are fundamental features of chronic kidney disease (CKD) that are substantially exacerbated in end-stage renal disease (ESRD). This study aimed at investigating the efficacy of a 6-month intradialytic exercise training program on RS, inflammation and physical performance in patients with ESRD. Twenty hemodialysis (HD) patients (17 males, three females) were randomly assigned to either an intradialytic training (bedside cycling) group (TR; n = 10) or a control group (CON; n = 10) for 6 months. Anthropometrics [body mass and height, body mass index (BMI), body composition], physical performance (VO2peak), functional capacity [North Staffordshire Royal Infirmary (NSRI) walk test, sit-to-stand test (STS-60)], quality of life (short form-36 (SF-36) as well as RS [thiobarbituric acid reactive substances (TBARS), protein carbonyls (PC), reduced (GSH) and oxidized (GSSG) glutathione, GSH/GSSG, total antioxidant capacity (TAC), catalase activity (CAT)] and high-sensitivity C-reactive protein (hs-CRP) were assessed at baseline and after the 6-month intervention. Peak oxygen consumption (VO2peak) increased by 15% only in TR (p < 0.01). Performance in NSRI, STS-60 and SF-36 improved by 4–13% only in TR (p < 0.01). Exercise training reduced TBARS (by 28%), PC (by 31%) and hs-CRP (by 15%), and elevated GSH (by 52%), GSH/GSSG (by 51%), TAC (by 59%) and CAT (by 15%) (p < 0.01). These findings suggest that engagement in chronic intradialytic cardiovascular exercise alters RS, reduces inflammation and improves performance in patients with ESRD.

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“…Therefore, reducing the body inflammation level of diabetes is of great significance for controlling and alleviating the development of diabetes. A large number of studies have been carried out on the effect of exercise on diabetic inflammatory factors [ 31 – 35 ], but the results are quite different. This study summarized recently published studies and found that long-term exercise can reduce the level of inflammatory factors (CRP, TNF- α , and IL-6) in T2DM, which may alleviate the chronic low-grade inflammation in patients to a certain extent.…”

Section: Discussionmentioning

confidence: 99%

Effects of Exercise on Inflammatory Cytokines in Patients with Type 2 Diabetes: A Meta-analysis of Randomized Controlled Trials

Chen

Sun

Wang

et al. 2020

Oxidative Medicine and Cellular Longevity

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Objective. Inflammation is involved in the pathogenesis of type 2 diabetes (T2DM) and the occurrence of insulin resistance. The purpose of this study was to investigate the effects of exercise on inflammatory factors in patients with T2DM. Methods. A systematic review was conducted on five databases, Cochrane, Embase, Pubmed, Web of Science, and EBSCO. All randomized controlled trials (RCTs) published between establishment of the database and November 2020 without restrictions on language were included. Studies evaluated the effects of exercise intervention on inflammatory cytokines in patients with T2DM were selected. Results. Twenty-three randomized controlled trials (1350 patients) were included in our meta-analysis. Exercise can significantly reduce the level of C-reactive protein (CRP) (MD: −0.79, 95% CI: −1.26 to −0.33, p = 0.0008 ), tumor necrosis factor-α (TNF-α) (MD: −2.33, 95% CI: −3.39 to −1.27, p < 0.0001 ), and interleukin-6 (IL-6) (MD: −0.42, 95% CI: −0.60 to −0.24, p < 0.0001 ) in T2DM patients. Conclusion. The findings of this review suggest that exercise reduces inflammatory cytokines (CRP, TNF-α, and IL-6) in T2DM patients. More studies with high methodological qualities and large sample sizes need to be done to confirm which forms of exercise are most effective.

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The effect of 12 weeks of aerobic training on serum levels high sensitivity C-reactive protein, tumor necrosis factor-alpha, lipid profile and anthropometric characteristics in middle-age women patients with type 2 diabetes

Cited by 21 publications

References 32 publications

Anti-Inflammatory Effects of Exercise on Metabolic Syndrome Patients: A Systematic Review and Meta-Analysis

Anti-Inflammatory Effects of Exercise on Metabolic Syndrome Patients: A Systematic Review and Meta-Analysis

Intradialytic Cardiovascular Exercise Training Alters Redox Status, Reduces Inflammation and Improves Physical Performance in Patients with Chronic Kidney Disease

Effects of Exercise on Inflammatory Cytokines in Patients with Type 2 Diabetes: A Meta-analysis of Randomized Controlled Trials

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