Effects of Exercise on Inflammatory Cytokines in Patients with Type 2 Diabetes: A Meta-analysis of Randomized Controlled Trials

Chen, Xiaoke; Sun, Xinzheng; Wang, Chenghao; He, Hongqing

doi:10.1155/2020/6660557

Cited by 26 publications

(21 citation statements)

References 79 publications

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“…This could possibly be because in patients with longstanding CAD and T2DM, the AT may develop into a more pro-inflammatory state, potentially rendering rigorous exercise training in such patients non-beneficial. Although previous findings mainly suggest otherwise [ 34 ], the populations in these studies had not yet developed complications from their T2DM. It might thus be suggested that the anti-inflammatory effects of exercise are primarily seen preventively, before developing complications.…”

Section: Discussionmentioning

confidence: 77%

Adiponectin in relation to exercise and physical performance in patients with type 2 diabetes and coronary artery disease

et al. 2021

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Introduction: Adipokines, expressed by adipose tissue (AT), have been associated with metabolic disturbances and coronary artery disease (CAD). The impact of exercise training on the AT in patients suffering from both diabetes and CAD is unknown. To gain knowledge on changes in ATs’ inflammatory profile in such a population, we investigated the effects of long-term exercise on selected adipokines and their associations with physical performance and glucometabolic variables. Adiponectin was selected based on its anti-atherogenic and anti-diabetic properties and visfatin and tumour necrosis factor (TNF) for their association with atherosclerosis and metabolic disorders. Not many studies have focused on the effects of long-term exercise training on adipokines in patients with concomitant T2DM and CAD. Methods: Patients with type 2 diabetes and CAD (n = 137), 41–81 years, 17.2% females, were randomized in a 1:1 manner to an exercise group, who underwent 1 year of 150 min weekly combined strength and endurance exercise, or a control group. AT from the gluteal region and blood samples were obtained at baseline and after 12 months, along with a physical performance test, assessed by the VO 2 peak. Circulating protein levels were measured by ELISA. RNA was extracted from AT and expression levels were relatively quantified by PCR. Results: After 1 year, no significant difference in the change in the investigated markers between the intervention group and the control group was observed. Changes in circulating adiponectin and VO 2 peak correlated in the total population (r = 0.256, p = 0.008). At baseline, circulating adiponectin and TNF correlated inversely with insulin and with C-peptide and VO 2 peak, respectively (p < 0.001, all). Conclusion: In this population with concomitant diabetes and CAD, ATs’ inflammatory profile remained unchanged apparently after 1 year of exercise intervention. Changes in the VO 2 peak were nevertheless, related to changes in circulating adiponectin levels. Trial registration: http://www.clinicaltrials.gov NCT01232608.

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Section: Discussionmentioning

confidence: 77%

Adiponectin in relation to exercise and physical performance in patients with type 2 diabetes and coronary artery disease

et al. 2021

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“…Furthermore, benefits on mental health, mood disorders (depression and anxiety), self-esteem, and well-being have been reported. Moreover, physical exercise leads to the reduction of inflammatory markers and oxidative stress [38], together with an improvement of the immune function. Thanks to its benefits on mental health, physical activity may alleviate psychological disturbances related to pandemia, quarantine and social isolation.…”

Section: Physical Activitymentioning

confidence: 99%

The mediterranean diet: Healthy and sustainable dietary pattern in the time of Sars-Cov-2

Bagnato

Perfetto

Labanca

et al. 2021

MNM

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COVID-19, first reported in Wuhan, China in December 2019 quickly spread worldwide leading to serious health, social and economic consequences. A crucial role in the pathogenesis of severe disease has been attributed to the inflammatory status, that in more severe cases may evolve in an overproduction of pro-inflammatory cytokines (“cytokine storm)” and fatal outcome. Non-communicable diseases, nutritional disorders and advanced age, conditions associated with a low-grade systemic inflammation and immune function alterations, have been identified as major risks for severe COVID-19. General recommendations for fighting COVID-19 highlighted the paramount importance of adopting a healthy plant-based dietary pattern and healthy lifestyle. The Mediterranean dietary pattern is considered as one of the healthiest dietary patterns, and its benefits are supported by a large body of evidence. Furthermore, it is considered as a sustainable lifestyle model. The aim of this research was to update the multiple benefits of the Mediterranean dietary pattern on physical and mental health, focusing on the effects that it may have in combating COVID-19. The potential effects and mechanisms of action of the main bioactive components of Mediterranean diet were also analyzed. Considering its effects in modulating inflammation and oxidative stress and supporting the immune system, the Mediterranean dietary pattern may be considered the most promising dietary approach to combat COVID-19.

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“…In this context, exercise could be a nonpharmacological intervention that may delay the progression of the disease and improve the management and quality of life of people with T2DM [ 2 ]. Accordingly, it has been suggested that exercise could delay the progression of insulin resistance [ 8 ] because of its effect on reducing circulating levels of inflammatory biomarkers such as CRP, TNF-α, and IL-6 [ 9 , 10 ]. In this sense, resistance exercise has gained importance for patients with T2DM [ 11 ] due to its multisystemic and specific musculoskeletal benefits [ 12 ].…”

Section: Introductionmentioning

confidence: 99%

Effectiveness of Resistance Exercise on Inflammatory Biomarkers in Patients with Type 2 Diabetes Mellitus: A Systematic Review with Meta-Analysis

et al. 2023

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Background: Type 2 diabetes mellitus (T2DM) is related to increased inflammatory processes. The effects of resistance exercise on inflammatory biomarkers in T2DM are controversial. Our purpose was to determine the effectiveness of resistance exercise on inflammatory biomarkers in patients diagnosed with T2DM.Methods: We searched four databases until September 2021. We included randomized clinical trials (RCTs) of the effects of resistance exercise on inflammatory biomarkers (C-reactive protein [CRP], tumor necrosis factor alpha, interleukin-6, and interleukin-10) in patients with T2DM. A random effects meta-analysis was conducted to determine the standardized mean difference (SMD) and the raw mean difference (MD) for CRP.Results: Thirteen RCTs were included in the review, and 11 in the meta-analysis for CRP. Lower CRP levels were observed when resistance exercise was compared with the control groups (SMD=–0.20; 95% confidence interval [CI], –0.37 to –0.02). When conducting the MD meta-analysis, resistance exercise showed a significant decrease in CRP of –0.59 mg/dL (95% CI, –0.88 to –0.30); otherwise, in the control groups, the CRP values increased 0.19 mg/dL (95% CI, 0.17 to 0.21).Conclusion: Evidence supports resistance exercise as an effective strategy to manage systemic inflammation by decreasing CRP levels in patients with T2DM. The evidence is still inconclusive for other inflammatory biomarkers.

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Effects of Exercise on Inflammatory Cytokines in Patients with Type 2 Diabetes: A Meta-analysis of Randomized Controlled Trials

Cited by 26 publications

References 79 publications

Adiponectin in relation to exercise and physical performance in patients with type 2 diabetes and coronary artery disease

Adiponectin in relation to exercise and physical performance in patients with type 2 diabetes and coronary artery disease

The mediterranean diet: Healthy and sustainable dietary pattern in the time of Sars-Cov-2

Effectiveness of Resistance Exercise on Inflammatory Biomarkers in Patients with Type 2 Diabetes Mellitus: A Systematic Review with Meta-Analysis

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