The effect of 3% binahong leaf extract gel on the wound healing process of post tooth extraction

Abstract

Background: One of the common frequently performed procedures in dentistry is tooth extraction. After tooth extraction, a series of biological events occurs in the alveolar socket that ultimately results in healing of the socket. Binahong (Anredera cordifolia) is an herbaceous plant that contains active compounds that may accelerate the wound healing process. Purpose: The aim of this study is to investigate the effect of 3% binahong leaf extract gel on the healing process of the postextraction wound. Methods: 3% binahong leaf extract gel was prepared with the composition of 1 g carbopol, 1 g hydroxypropilmethylcellulose (HPMC), 4 g glycerin, 3 g triethanolamine (TEA), 0.04 g Nipagin, 0.04 g Nipasol, 1.2 g binahong leaf extract and Aq ad 40 g. A total of 18 people were subjected to tooth extraction and were then divided into two groups, with nine people in the binahong group and nine in the control group. Following that, residual socket volume (RSV) was examined on days 3, 7 and 14 after the extraction in both the binahong and control groups. The RSV value was obtained by calculating the mesiodistal x bucolingual width x the depth probing and measured using a calliper and probe. Repeated analysis of variance (ANOVA) and Friedman test followed by Wilcoxon and dependent t-test (p<0.05) were used to analyse data. Results: Significant difference in the mean RSV between the control and binahong groups was observed on days 3, 7 and 14 post tooth extraction. The RSV value in the binahong group was lower when compared to the control group (p <0.05). Conclusion: 3% binahong leaf extract gel can accelerate the process of healing socket wounds.

The Effect of Ramania Leaves Extract Gel (Bouea macrophylla Griff) on the Number of Osteoblast (in vivo Study of Post Extraction in Wistar Rats (Rattus norvegicus))

“…4,5 Healing after tooth extraction consists of three phases, namely the inflammatory phase, the proliferative phase, and the remodeling phase. 6 The healing process after tooth extraction begins with the presence of a blood clot that clogs the broken blood vessel to stop the bleeding. In the inflammatory phase, the wound area will be dominated by inflammatory cells, namely neutrophils and macrophages that have a phagocytic function and the release of growth factors that will stimulate the proliferation and differentiation of osteoprogenitor cells into osteoblasts on the 5th day after tooth extraction.…”

The role of purple leaves extract (Graptophyllum Pictum (L.) Griff) on the number of fibroblasts and blood vessels in the socket after tooth extraction

“…12 In addition, if, after tooth extraction, the wound fails in one of the healing phases, especially in the angiogenesis process, the wound cannot heal properly. 13 Drugs can reduce complications and speed up the wound recovery process after tooth extraction. Complications may occur in inadequate tooth extraction.…”

“…One of the non-steroidal anti-inflammatory drugs that is often used after tooth extraction is diclofenac. Nevertheless, previous studies reported that diclofenac administration could inhibit the formation of blood clots and fibroblasts; 12,13 therefore, an alternative drug to minimize the side effects of diclofenac administration is necessary. Purple leaves are known as plants with anti-inflammatory effects and have been reported to increase the number of fibroblasts in rats induced by Porphyromonas gingivalis in their sulcus.…”

Binahong leaf extract (anredera cordifolia) mucoadhesive patch as an alternative therapy for recurrent aphthous stomatitis

“…as antimicrobials work by inhibiting the synthesis of proteins, lipids, and bacterial DNA. Not only that, saponins which are anticarcinogenic and antiseptic can inhibit the growth of microorganisms present in the wound, so it does not aggravate wound infection 15,16. Other content in saponins also plays a role in increasing the proliferation of fibroblast cells.…”

“…The mechanism of action of saponins in ulcer healing is by stimulating the production of type I collagen which has an important role in the wound closure process and increases the speed of tissue epithelialization 5. Saponins obtained after extracting binahong leaves act as angiogenetic agents that can increase cell activity in the formation of blood vessels during the proliferative phase of wound healing 15. In research conducted byHanafiah et al (2019) observed the proliferative activity of fibroblast cells 3T3 5.…”