The effect of 3D-printed Ti6Al4V scaffolds with various macropore structures on osteointegration and osteogenesis: A biomechanical evaluation

Wang, Han; Su, Kexin; Su, Leizheng; Liang, Panpan; Ji, Ping; Wang, Chao

doi:10.1016/j.jmbbm.2018.08.049

Cited by 97 publications

(80 citation statements)

References 42 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Moreover, studies on subject animals showed that the lightened and surface-roughened implants provide a good integration with the bone in the implantation area. [11][12][13][14] Koch et al studied the histopathological findings concerning the bone-implant interface of a titanium mesh acetabular cup after 27 years in a human body. 15 The findings indicated an adaptive bone remodeling at the interface to the deep solid core of the acetabular cup.…”

Section: Introductionmentioning

confidence: 99%

Design, manufacture, and fatigue analysis of lightweight hip implants

Delikanlı

Kayacan

2019

Journal of Applied Biomaterials & Functional Materials

View full text Add to dashboard Cite

Background: This study aims to design, analyze and manufacture lightweight hip implants which have sufficient fatigue performance to enable use in total hip arthroplasty (THA). Methods: The lattice structure was applied on an implant geometry, which is frequently used in THA, to provide a reduction in mass and increase flexibility. The implant surfaces were roughened using semispherical pores to improve the osseointegration. The specimens were manufactured by means of direct metal laser sintering (DMLS) and fatigue tests were performed according to ISO 7206-4:2010. Moreover, fatigue analyses of the designed implants were numerically carried out using the finite element method. Results: The applied lattice structure on implant geometry leads to 15-17% reduction in the masses of implants compared to a solid one. It has also been determined that the lightweight implants show more flexible behavior with increasing pore diameter used on the implant surfaces while keeping the lattice structure geometry constant. The fatigue test and finite element analysis (FEA) results are in reasonable agreement. In addition, additively manufactured solid implants have exhibited similar fatigue performance with one produced by conventional methods. Conclusions: This paper presents design, analysis, manufacturing and fatigue test processes of lightweight hip implants. The lattice structure and the semispherical pores were applied on a reference implant geometry and they were manufactured by DMLS. The fatigue tests and FEA were performed to evaluate newly designed implant performance. All the implants successfully completed the fatigue tests without any damage.

show abstract

Section: Introductionmentioning

confidence: 99%

Design, manufacture, and fatigue analysis of lightweight hip implants

Delikanlı

Kayacan

2019

Journal of Applied Biomaterials & Functional Materials

View full text Add to dashboard Cite

show abstract

“…An Ansys Workbench program (Ansys, USA) was utilized to calculate the Elastic Modulus . The Elastic Modulus of AH‐Sr‐AgNPs implants (4.88 ± 0.25 GPa) was quite similar to that of cancellous bone (4.76 ± 0.33 GPa) ( Figure A).…”

Section: Resultsmentioning

confidence: 95%

“…Preparation of Titanium Plate and Porous Titanium Implant : Titanium (Ti) implants with pore structure were designed by computer‐aided design and cylinders (ϕ = 3 mm × 8 mm) were manufactured by selective laser melting using commercially pure titanium (Cp‐Ti, Grade 4) . The average diameter of the pore size was 390 ± 1.33 µm, and strut size was 200 ± 0.53 µm with an average porosity of 76.79 ± 0.83%.…”

Section: Methodsmentioning

confidence: 99%

“…Characterization of Different Ti Substrates as Well as In Vitro Ion Release Tests—Mechanical Evaluations : Mechanical properties of the implants were determined using the compression test with a computer‐controlled universal testing machine (MTS, USA) . The mechanical properties of cortical bone and cancellous bone from New Zealand rabbits were examined as well.…”

Section: Methodsmentioning

confidence: 99%

See 1 more Smart Citation

Effects of Programmed Local Delivery from a Micro/Nano‐Hierarchical Surface on Titanium Implant on Infection Clearance and Osteogenic Induction in an Infected Bone Defect

Shrestha

et al. 2019

Adv Healthcare Materials

Self Cite

View full text Add to dashboard Cite

The two major causes for implant failure are postoperative infection and poor osteogenesis. Initial period of osteointegration is regulated by immunocytes and osteogenic‐related cells resulting in inflammatory response and tissue healing. The healing phase can be influenced by various environmental factors and biological cascade effect. To synthetically orchestrate bone‐promoting factors on biomaterial surface, built is a dual delivery system coated on a titanium surface (abbreviated as AH‐Sr‐AgNPs). The results show that this programmed delivery system can release Ag+ and Sr2+ in a temporal‐spatial manner to clear pathogens and activate preosteoblast differentiation partially through manipulating the polarization of macrophages. Both in vitro and in vivo assays show that AH‐Sr‐AgNPs‐modified surface renders a microenvironment adverse for bacterial survival and favorable for macrophage polarization (M2), which further promotes the differentiation of preosteoblasts. Infected New Zealand rabbit femoral metaphysis defect model is used to confirm the osteogenic property of AH‐Sr‐AgNPs implants through micro‐CT, histological, and histomorphometric analyses. These findings demonstrate that the programmed surface with dual delivery of Sr2+ and Ag+ has the potential of achieving an enhanced osteogenic outcome through favorable immunoregulation.

show abstract

“…And the possibility of these lattice structures as implant structures was fully verified via extensive experimental data. Moreover, Wang et al [103] successfully applied the tetrahedral lattice structure to the implant. Other researchers have also studied the polyhedral lattice structures [6,104,105], which further broaden the choice of implant structure.…”

Section: Lattice Structure Designmentioning

confidence: 99%

Additive Manufacturing of Customized Metallic Orthopedic Implants: Materials, Structures, and Surface Modifications

Bai

Cheng

Chen

et al. 2019

Metals

131

View full text Add to dashboard Cite

Metals have been used for orthopedic implants for a long time due to their excellent mechanical properties. With the rapid development of additive manufacturing (AM) technology, studying customized implants with complex microstructures for patients has become a trend of various bone defect repair. A superior customized implant should have good biocompatibility and mechanical properties matching the defect bone. To meet the performance requirements of implants, this paper introduces the biomedical metallic materials currently applied to orthopedic implants from the design to manufacture, elaborates the structure design and surface modification of the orthopedic implant. By selecting the appropriate implant material and processing method, optimizing the implant structure and modifying the surface can ensure the performance requirements of the implant. Finally, this paper discusses the future development trend of the orthopedic implant.

show abstract

The effect of 3D-printed Ti6Al4V scaffolds with various macropore structures on osteointegration and osteogenesis: A biomechanical evaluation

Cited by 97 publications

References 42 publications

Design, manufacture, and fatigue analysis of lightweight hip implants

Design, manufacture, and fatigue analysis of lightweight hip implants

Effects of Programmed Local Delivery from a Micro/Nano‐Hierarchical Surface on Titanium Implant on Infection Clearance and Osteogenic Induction in an Infected Bone Defect

Additive Manufacturing of Customized Metallic Orthopedic Implants: Materials, Structures, and Surface Modifications

Contact Info

Product

Resources

About