The Effect of a Carbonic Anhydrase Inhibitor, Diamox, On Human Pancreatic Secretion

Dreiling, David A.; Janowitz, Henry D.; Halpern, Mark

doi:10.1016/s0016-5085(19)36031-7

Cited by 65 publications

(9 citation statements)

References 25 publications

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“…In view of our hypothesis an additional interpretation of the pancreatic lesion in cystic fibrosis patients can be proposed. Under normal conditions secretin promotes secretion of bicarbonate and water into the pancreatic duct system [5]. Microperfusion experiments studying the transport mechanism in the rabbit pancreas resulted in the theory that the secretion of bicarbonate is linked to the reabsorption of hydrogen ions from the duct lumen across the luminal membrane into the cella of the pancreatic ducts [21].…”

Section: Discussionmentioning

confidence: 99%

Diminished Excretion of Bicarbonate from the Single Sweat Gland of Patients with Cystic Fibrosis of the Pancreas*

Kaiser

Drack

1974

Eur J Clin Investigation

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Using pH-microelectrodes the excretion of Reduced flux of protons across the luminal membrane of hydrogen-ions and bicarbonate in relation to flow rate was epithelial cells is proposed as a general feature of exocrine investigated in a single sweat gland of cystic fibrosis children. gland defects. It is then possible to describe both the cationicThe results show decreased excretion of hydrogen-ions transport defect of the sweat gland duct and the anionic and an increased excretion of bicarbonate. Evidence is pre-bicarbonate-secretory defect in one term. sented that due to reduced secretion of hydrogen-ions in the duct both the reabsorption of sodium and the secretion of Key Words: Cystic fibrosis, bicarbonate, single sweat gland, potassium may be impaired. electrolyte transport defect. The possibility is discussed that reduced flux of hydrogenions may similarly be reRponsible for the excretory defect in the duct system of the pancreas.

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Section: Discussionmentioning

confidence: 99%

Diminished Excretion of Bicarbonate from the Single Sweat Gland of Patients with Cystic Fibrosis of the Pancreas*

Kaiser

Drack

1974

Eur J Clin Investigation

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“…Double secretin tests (Dreiling, Janowitz, and Halpern, 1955;Dreiling and Janowitz, 1960) were performed on 18 healthy subjects who were established cigarette smokers; nine were classified as light smokers (less than one pack of cigarettes per day for less than three years) and nine were designated heavy smokers (more than one pack of cigarettes per day for more than three years). Light smokers consisted of seven males and two females ranging from 15 to 26 years of age (mean 21 years).…”

Section: Test Groupmentioning

confidence: 99%

“…Then a tandem secretin test was done on each subject as described by Dreiling et al (1955) and Dreiling and Janowitz (1960). A 20-minute basal period was begun, during which both gastric and duodenal secretions were collected.…”

Section: Test Groupmentioning

confidence: 99%

Inhibition of pancreatic secretion in man by cigarette smoking

Bynum¹,

Solomon²,

Johnson³

et al. 1972

Gut

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SUMMARY Cigarette smoking has been linked to an elevated incidence of duodenal ulcer disease in smokers, although the mechanism is unclear. In 23 young normal subjects single or double secretin tests were performed during non-smoking and smoking periods. Cigarette smoking inhibited the secretion of pancreatic juice and bicarbonate in light smokers ( < one pack/day for < three years). Heavy smokers ( > one pack/day for > three years) exhibited depressed pancreatic secretory rates during non-smoking periods. Inhibition of pancreatic alkaline secretion by cigarette smoking could be the link between the habit and duodenal ulcer disease.

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“…Interesting studies relating to carbonic anhydrase and pancreatic secre tion by Dreiling et al (216) indicate that the powerful carbonic anhydrase inhibitor acetazoleamide (Diamox) depresses the total volume and total bicarbonate response of the pancreas to secretin. The basal rates of pancreatic flow and bicarbonate secretion also appear to be inhibited while bicarbonate concentration is unaffected.…”

Section: Physiologymentioning

confidence: 99%