The effect of a commercial feed additive on the immune-metabolic axis, liver function and predicted carcass quality in purebred Angus steers

Armstrong, S. A.; McLean, D. J.; Bobe, Gerd

doi:10.1016/j.livsci.2018.02.002

Cited by 9 publications

(4 citation statements)

References 48 publications

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“…Mezzetti et al [ 29 ] observed similar effects on RBC in transition cows fed OMN. As reported by other authors, OMN exerts effects on white blood cells [ 15 , 24 , 33 , 70 ]. In the present study, we observed a change in the proportion of white blood cells species in OMN treated cows, with a decrease in LYM ( Figure 3 c) compensated by an increase in NEU ( Figure 3 b).…”

Section: Discussionsupporting

confidence: 61%

Effect of an Immunomodulatory Feed Additive in Mitigating the Stress Responses in Lactating Dairy Cows to a High Concentrate Diet Challenge

Cavallini

Mammi

Palmonari

et al. 2022

Animals

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Dairy cows are often exposed to multiple stressors in a lactation-cycle, with sub-acute ruminal acidosis (SARA) a frequent example of nutritional stress. SARA affects ruminal and intestinal equilibrium resulting in dysbiosis with localized and systemic inflammation impacting animal health and productivity. OmniGen-AF (OMN, Phibro Animal Health Corporation, Teaneck, NJ, USA) is a feed product recognized for modulating innate immune function, especially during periods of stress. The objective of this study was to determine the effects of OMN in lactating dairy cows fed a high-starch, low-fiber diet. Twenty-four blocked cows were assigned to control or treatment (55 g/d). After the additive adaptation (49 d) cows were fed the challenge diet (28 d). Milk, rumination and pH were continuously recorded; components, rumen fluid, and blood were taken in multiple time-point and analyzed. Results showed that the challenge decreased the rumination, shifted ruminal fluid composition, decreased milk production and the components, and slightly increased the time below pH 5.5, with no differences between groups. The treatment produced greater rumen butyrate and lower lactate, prompter regeneration of red blood cells, increase of neutrophils, lower paraoxonase, gamma-glutamyl-transferase, and β-hydroxybutyrate, with no differences on other tested inflammatory markers. Results show that OMN helps modulating some of the metabolic and immunological responses to SARA.

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Section: Discussionsupporting

confidence: 61%

Effect of an Immunomodulatory Feed Additive in Mitigating the Stress Responses in Lactating Dairy Cows to a High Concentrate Diet Challenge

Cavallini

Mammi

Palmonari

et al. 2022

Animals

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“…Despite the microbiological profiles (Staphylococcus, Coliform, and TBC) showing no significant differences between groups, but they recorded a lower proportion in animals' milk that received potassium supplementation (treatment group) compared to the control group. These results could be attributed to the influence of feed additives on enhancing the immune system of treatment cows, where the finding of this study agreed with results concluded by Armstrong et al (2018). Steele M (2016) reported that the natural immune function might be suppressed in lactating cows during heat stress which led to an increase in the risk of clinical diseases like mastitis and metritis.…”

Section: Discussionsupporting

confidence: 91%

Supplementary Practices Improving Holstein Cattle Performance During Hot Seasons

Abdelghany¹,

Allouche²,

El-Maksoud³

et al. 2021

AAVS

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Heat stress is a major problem facing dairy producers and negatively influences production, performance, and welfare. The study aims to improve milk production and quality during the hot season, which supports milk safety and dairy chain sustainability. Forty-two Holstein cows in the middle of the first lactation were used and divided into a control group (22 cows) that received control diet and a treatment group (20 cows) that received a control diet supplemented with 200 g of potassium carbonate through 30 days. Milk yield for all cows were recorded, while a total number of 84 milk samples were collected on the tenth day of the trial and at the last day of the trail. In addition, 16 blood samples were collected for both groups. Milk composition, somatic cell count (SCC), and bacterial profile were evaluated. The results indicated that the average milk yield was higher in the treatment group, which increased by 10.3%, while the fat % was decreased by 21-25% compared with the control group. The physiological parameters gave no significant differences between groups, except urea which recorded higher levels in the treatment group (34.6 vs. 30.6 mg/dl). SCC was significantly decreased by 52.5-56.3% compared with the control. Also, a significant enhancement of milk stability against overheating was recorded in the treatment group. The study proved that using potassium carbonate at the farm level during hot season could improve milk production and quality, subsequently, it might extend shelf life, safety, and stability of raw milk supplied through the dairy chain.

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“…Serum ammonia content, alanine transaminase, aspartate transaminase, and cholinesterase activity, served as hepatic health indicators according to previous studies with human and domestic animals (24)(25)(26)(27) , were evaluated using reagent kits purchased from Nanjing Jiancheng Bioengineering Institute following the manufacturer's protocol.…”

Section: Measurements Of Hepatic Health Indicatorsmentioning

confidence: 99%

Application of N-carbamylglutamate in Rex rabbits to reduce body fat deposition and its possible mechanism

Wang

Shao

et al. 2020

Br J Nutr

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N-Carbamylglutamate (NCG) has been shown to enhance arginine synthesis and improve growth performance in animals. However, the effect of NCG on body fat deposition remains unknown. This study examined the effects of NCG on body fat deposition and evaluated the potential mechanisms involved. Rex rabbits (3 months old) were assigned to one of four dietary groups and supplemented with NCG at the following different concentrations in a feeding trial that lasted 67 d: 0 (control), 0·04, 0·08, and 0·12 %. NCG supplementation increased serum concentrations of arginine and proline by activating intestinal carbamoylphosphate synthase-І at the posttranscriptional level. Final body weights and growth performance were not affected by dietary NCG levels. However, NCG-treated rabbits had lower perirenal and subcutaneous fat percentages, serum TAG content, and hepatic fatty acid synthase (FAS) activity and increased NO synthase activity and serum levels of NO, growth hormone (GH), and insulin-like growth factor 1 (IGF-1). There were significant positive correlations between TAG content and perirenal fat percentage, as well as FAS activity and perirenal fat percentage, but significant negative correlations between TAG and NO levels, and FAS activity and IGF-1 level in rabbits after NCG treatment. NCG supplementation did not affect hepatic health indicators, except for serum ammonia concentrations, which were decreased in NCG-treated rabbits. Our results suggest that NCG can serve as a dietary supplement to reduce unfavourable fat deposition through inhibiting hepatic lipogenesis in animals since it appears to have no negative effects on growth performance or hepatic health.

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The effect of a commercial feed additive on the immune-metabolic axis, liver function and predicted carcass quality in purebred Angus steers

Cited by 9 publications

References 48 publications

Effect of an Immunomodulatory Feed Additive in Mitigating the Stress Responses in Lactating Dairy Cows to a High Concentrate Diet Challenge

Effect of an Immunomodulatory Feed Additive in Mitigating the Stress Responses in Lactating Dairy Cows to a High Concentrate Diet Challenge

Supplementary Practices Improving Holstein Cattle Performance During Hot Seasons

Application of N-carbamylglutamate in Rex rabbits to reduce body fat deposition and its possible mechanism

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