The effect of a deproteinized bovine bone mineral on bone regeneration around titanium dental implants®

Abstract

The aim of the present experiment was to test the effect of a deproteinized bovine bone mineral (Bio-Oss) on guided bone regeneration (GBR) in dehiscence defects around implants. The first 2 molars and all premolars were extracted on both sides of the mandibles of 3 monkeys (Macaca fascicularis). Three months later, 2 titanium plasma-coated cylindrical implants were placed in all quadrants of each monkey. During the surgical procedure, standardized dehiscence defects were produced buccally and lingually, measuring 2.5 mm in width and 3 mm in height. Four different experimental situations were created: 2 sites in each monkey were covered with an ePTFE membrane (M), 2 were filled with the graft material (DBBM), 2 were filled with the graft material and also covered with a membrane (M + DBBM), and 2 control sites were neither grafted nor covered (C). The flaps were sutured to allow for primary healing. Linear measurements of bone height and width were calculated on histological specimens obtained 6 months following surgery. In addition, values for bone density and for surface fraction of graft to new bone contact were measured. Vertical bone growth along the implant surface of 100% (SD 0%) for M + DBBM, 91% (SD 9%) for M, 52% (SD 24%) for DBBM, and 42% (SD 35%) for C was measured. The width of the regenerated bone 1.5 mm above the bottom of the original defect, i.e. at the 50% mark of the vertical extension of the defect, in relation to the width at the bottom of the defect amounted to 97% (SD 2%) for M + DBBM, 85% (SD 9%) for M, 42% (SD 41%) for DBBM, and 23% (SD 31%) for C. Assessment of bone density within the confinement of the regenerated bone resulted in an increase of 30% (SD 11%) for M + DBBM, 45% (SD 20%) for M, 33% (SD 20%) for DBBM, and 22% (SD 23%) for C. The values for graft to new bone contact within this compartment amounted to 80% (SD 15%) for M + DBBM and 89% (SD 14%) for DBBM. In conclusion, Bio-Oss exhibited osteoconductive properties and hence can be recommended for GBR procedures in dehiscence defects with respect to vertical and horizontal growth of bone.

Synergistic Effects of Growth Factor, Bone Graft, and Resorbable Barrier Membrane in Management of Dehiscence and Fenestration of Dental Implants

“…15 Bone regeneration utilizing one-stage procedure around submerged implants has been successful both in humans 13,14,[16][17][18][19] and animals. [20][21][22][23] Reconstruction of bony defects in alveolar ridge is one of the major challenges that continued to perplex the periodontist. Restoration of these defects becomes all the more important when we desire to place the implants in prosthetically determined and esthetically pleasing position.…”

Effect of bone graft materials on bone formation in guided bone regeneration using perforated titanium membrane

“…골유도재생술시 차폐막의 함몰을 보완하고 골형성 량을 증가시키기 위하여 골이식재를 사용하고 있다 [32][33] . 탈단백우골은 골유도재생술과 상악동거상술에 널리 사용되고 있고 우수한 골전도효과와 생체친화 성이 있다고 보고 되었다 [34][35][36][37] . 탈회동결건조골에 대 한 효과에 대하여 상반된 견해가 있지만 두개 결손 부 [38][39] 와 장골 결손부 40) , 치조골 결손부 .…”

Augmentation of Peri-implant Bone Defects with Different Bone Grafts and Guided Bone Regeneration:

“…Autogenous bone grafts as well as other bone substitutes combined with membrane technique have been extensively used to augment a compromised alveolar ridge and to prepare the site for dental implant installation [1][2][3] . Autologous bone can be harvested from iliac crest, mental portion of mandibula and ribs.…”