The Effect of a Low Carotenoid Diet on Malondialdehyde-Thiobarbituric Acid (MDA-TBA) Concentrations in Women: A Placebo-Controlled Double-Blind Study

Abstract

These findings provide evidence to support the beneficial effects of carotenoids in preventing lipid peroxidation in the cells. Further studies are needed to identify the exact mechanism by which carotenoids prevent lipid peroxidation and the amount needed for normal activity.

Diet quality scores and oxidative stress in Korean adults

“…Oxidized low-density lipoprotein has been hypothesized as a causative agent in the development of cardiovascular disease, and oxidized DNA may have a role in human carcinogenesis, although a causal relationship has not yet been firmly established (Poulsen et al, 1998). Among biomarkers related to oxidative stress, MDA concentrations in plasma and urine have been reported to respond to alterations in antioxidant nutrient status (Winklhofer-Roob et al, 1995;Lepage et al, 1996;Dixon et al, 1998). However, the dietary quality scores used in this study did not show any correlations with the biomarker for DNA oxidative stress, 8-OHdG.…”

Dietary restriction of lycopene for a period of one month resulted in significantly increased biomarkers of oxidative stress and bone resorption in postmenopausal women

“…It is possible that these antioxidant enzymes acted in place of lycopene, moderating the resultant increases in oxidative stress biomarkers. A longer period of depletion may have magnified the reported effect of dietary lycopene restriction on lipid and protein oxidation (20,21).…”

“…Dietary lycopene restriction is necessary to obtain a clinically relevant response to lycopene, as it has been shown that higher baseline lycopene concentrations result in a moderate to null response to lycopene (19). However, studies on the effects of a carotenoid-depleted diet are limited and those that exist examined small study populations (N<10), very few biomarkers of oxidative stress, and did not report on how this type of diet would affect the risk of developing agerelated chronic diseases (20)(21)(22). Studies on lycopene depletion are important not only because they may delineate crucial functions, but they also help to elucidate mechanisms which may not be accurately demonstrated in intervention studies where absorption saturation occurs (23).…”

Assessment of Oxidative Stress and Antioxidant Status Among Petrol Stations’ Workers Exposed to Benzene in Zagazig City

“…Serum level of MDA was measured according to the method of Ohkawa et al (10) . The reference range of MDA was 0.12 -1.71 nmol/ml (11) . (3) Assay of Antioxidants activity (Superoxide Dismutase SOD): Venous blood samples collected in K-EDTA tubes is used.…”