The effect of a low carbohydrate ketogenic diet with or without exercise on postpartum weight retention, metabolic profile and physical activity performance in postpartum mice

Hsu, Yi-Ju; Huang, Chi‐Chang; Lin, Chih‐Yuan

doi:10.1016/j.jnutbio.2022.108941

Cited by 3 publications

(2 citation statements)

References 64 publications

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“…After the habituation period, rodents fed with a KD usually consume less food expressed in grams but equal calories as the animals fed with standard chow. This trend was observed in wild-type animals fed with KD for up to 2 months (26,55,57,83,(137)(138)(139)(140)(141) or longer (58,(142)(143)(144)(145) as well as in different disease models like T2DM model (146), AD model (54), in the stress model (92), glaucoma model in both females and males (147), models of hepatic enzyme disturbances (148,149), and in acute alcohol withdrawal symptoms (120). However, despite the equivalent caloric intake, feeding with KD often results in improved body mass (26,83,138,140,144) and metabolic health in long-term treatment (65).…”

Section: Nutritional Behaviormentioning

confidence: 93%

Ketogenic diet and behavior: insights from experimental studies

Grabowska,

Grabowski,

Przybyła

et al. 2024

Front. Nutr.

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As a journal page for full details. The ketogenic diet (KD) has been established as a treatment for epilepsy, but more recently it has been explored as an alternative or add-on therapy for many other diseases ranging from weight loss to neurological disorders. Animal models are widely used in studies investigating the therapeutic effects of the KD as well as underlying mechanisms. Especially in the context of neurological, psychiatric, and neurodevelopmental disorders essential endpoints are assessed by behavioral and motor tests. Here we summarized research evaluating the influence of the KD on cognition, depressive and anxiety-related behaviors, and social and nutritional behaviors of laboratory rodents. Each section contains a brief description of commonly used behavioral tests highlighting their limitations. Ninety original research articles, written in English, performed on mice or rats, providing measurement of blood beta-hydroxybutyrate (BHB) levels and behavioral evaluation were selected for the review. The majority of research performed in various disease models shows that the KD positively impacts cognition. Almost an equal number of studies report a reduction or no effect of the KD on depressive-related behaviors. For anxiety-related behaviors, the majority of studies show no effect. Despite the increasing use of the KD in weight loss and its appetite-reducing properties the behavioral evaluation of appetite regulation has not been addressed in preclinical studies. This review provides an overview of the behavioral effects of nutritional ketosis addressed to a broad audience of scientists interested in the KD field but not necessarily specializing in behavioral tests.

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Section: Nutritional Behaviormentioning

confidence: 93%

Ketogenic diet and behavior: insights from experimental studies

Grabowska,

Grabowski,

Przybyła

et al. 2024

Front. Nutr.

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“…In this way, Thomson and colleagues indicated that a low carbohydrate diet with 30% protein, 40% carbohydrate, and 30% fat on 94 overweight and obese women with PCOS during 20 weeks could decrease fat mass and fat-free mass 3 and 2 kg, respectively [ 18 ]. The ketogenic diet is a nutrition protocol of high-fat (70–80%), very low-carbohydrate (5–10%) diet which represent beneficial effects in a number of diseases, including obesity, neurological disorders, type 2 diabetes mellitus, cancer, and PCOS [ 19 , 20 ]. The role of a ketogenic diet on PCOS is through the reduction of the amount of circulating glucose and insulin, which results in both declining glucose oxidation and increasing fat oxidation [ 21 ].…”

Section: Introductionmentioning

confidence: 99%

A comparison of the portfolio low-carbohydrate diet and the ketogenic diet in overweight and obese women with polycystic ovary syndrome: study protocol for a randomized controlled trial

Najafabadi

Moludi

Salimi

et al. 2023

Trials

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Background Polycystic ovary syndrome (PCOS) is one of the most frequent endocrine disorders among women of fertile age. Women with PCOS manifest clinical symptoms like menstrual dysfunction, hirsutism, insulin resistance, and hyperinsulinemia. As excessive amounts of insulin levels directly increase ovarian production of androgens, hyperinsulinemia and insulin resistance are considered as the pathogenesis factors of PCOS. The portfolio low-carbohydrate diet (PLCD) is a plant-based diet with 40% carbohydrates combined with five cholesterol-lowering foods and nutrients. On the other hand, the ketogenic diet (KD) is a nutritional protocol with 10% carbohydrates. The purpose of this study is to determine whether PLCD or KD is more effective in alleviating PCOS symptoms. Methods Forty-six overweight or obese women diagnosed with PCOS will be randomly stratified to receive either PLCD or KD for 8 weeks. Measures related to anthropometric and body composition, glucose, and insulin level, HOMA-IR, sex hormones, lipid profile, quality of life, dietary intake, physical activity, and Ferriman-Gallwey score of all participants will be accessed before and after the intervention. Discussion Since the first line treatment of PCOS is lifestyle adjustment including diet control and exercise, there has not been determined the optimal diet for this population of women yet. Hence, the goal of conducting this study is to determine whether the PLCD or the KD could have more advantageous effects on attenuating PCOS manifestations. The result of this investigation will give us new insight into curing this disease and will provide evidence-based recommendations for prescribing an optimal diet for PCOS women. Trial registration IRCT20200912048693N3, Trial registered 2022–12-14. https://www.irct.ir/trial/67548

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Low-Carbohydrate Ketogenic Diet for Improvement of Glycemic Control: Mechanism of Action of Ketosis and Beneficial Effects

Sakr

Sirasanagandla

Das

et al. 2023

CDR

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The incidence of metabolic syndrome and diabetes mellitus is increasing globally. A diet rich in carbohydrates increases the hyperglycemic state. While considering the lifestyle changes to combat life-threatening diseases, there is an effort to decrease the daily intake of carbohydrates. A low-carbohydrate diet also makes the body rely more on fat for energy, so there is less fat accumulation. A diet is considered to be low-carbohydrate ketogenic if the intake is ≤ 50 g per day. The ‘low -carbohydrate ketogenic diet’ (LCKD) produces ketosis. LCKD contains high-fat, moderate-protein, and low-carbohydrate components. The main objectives of the present review are to discuss insulin resistance in different viscera of the body, describe the role of adipokines in insulin resistance, understand the mechanism of ketogenesis, and determine the impact of LCKD in overcoming insulin resistance in the body. In the present review, we also highlight the beneficial effects of LCKD in metabolic, neurodegenerative, cardiovascular, lipid disorders, and also discuss the effect on longevity and aging. LCKD may help in combating the morbidity and mortality arising from the above-mentioned diseases and also help in leading a better quality of life.

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The effect of a low carbohydrate ketogenic diet with or without exercise on postpartum weight retention, metabolic profile and physical activity performance in postpartum mice

Cited by 3 publications

References 64 publications

Ketogenic diet and behavior: insights from experimental studies

Ketogenic diet and behavior: insights from experimental studies

A comparison of the portfolio low-carbohydrate diet and the ketogenic diet in overweight and obese women with polycystic ovary syndrome: study protocol for a randomized controlled trial

Low-Carbohydrate Ketogenic Diet for Improvement of Glycemic Control: Mechanism of Action of Ketosis and Beneficial Effects

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