The effect of a new wound dressing on wound healing: Biochemical and histopathological evaluation

Tort, Serdar; Tuğcu-Demiröz, Fatmanur; Cevher, Şule Çoşkun; Sarıbaş, Sanem; Özoğul, Candan; Acartürk, Füsun

doi:10.1016/j.burns.2019.02.013

Cited by 42 publications

(24 citation statements)

References 48 publications

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“…According to the obtained results, nanofiber wound dressing significantly decreased MDA levels of tissues (7.55 nmol/g) compared with the both negative control (non-treated, 21.7 nmol/g) and positive control (Promogran V R , 15.9 nm/g). 86 Also, the tissue's GSH levels in nanofiber treated wounds was higher than negative control samples in all phases of wound healing. 86 In another study by Ajmal et al 87 ciprofloxacin hydrochloride and quercetin functionalized nanofibers (PCL/CHL/Que-nanofiber) were prepared and their antioxidant activity was demonstrated by DPPH (2,2-diphenyl-1-picrylhydrazyl) scavenging assay.…”

Section: Scaffolds Characterizationmentioning

confidence: 91%

“…86 Also, the tissue's GSH levels in nanofiber treated wounds was higher than negative control samples in all phases of wound healing. 86 In another study by Ajmal et al 87 ciprofloxacin hydrochloride and quercetin functionalized nanofibers (PCL/CHL/Que-nanofiber) were prepared and their antioxidant activity was demonstrated by DPPH (2,2-diphenyl-1-picrylhydrazyl) scavenging assay. Based on in vivo studies significant antioxidants level improvement (SOD and catalase assay, p < 0.5) in PCL/CHL/Que-nanofiber treated samples and consequently high wound healing effect was observed.…”

Section: Scaffolds Characterizationmentioning

confidence: 91%

“…It was showed that this scaffold increased the level of ROS related enzymes activities (catalase and superoxide dismutase) by enhancing their gene expression level. 85 In another study performed by Tort et al 86 doxycycline as an antibiotic was loaded onto chitosan/collagen nanofibers and used for wound healing applications. According to the obtained results, nanofiber wound dressing significantly decreased MDA levels of tissues (7.55 nmol/g) compared with the both negative control (non-treated, 21.7 nmol/g) and positive control (Promogran V R , 15.9 nm/g).…”

Section: Scaffolds Characterizationmentioning

confidence: 99%

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Bioactive anti-oxidative polycaprolactone/gelatin electrospun nanofibers containing selenium nanoparticles/vitamin E for wound dressing applications

et al. 2021

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In this study, polycaprolactone/gelatin (PCL/GEL) electrospun nanofibers containing biogenic selenium nanoparticles (Se NPs) and Se NPs/vitamin E (VE) with average diameters of 397.8 nm and 279.5 nm, respectively (as determined by SEM inspection) were prepared and their effect on wound healing was evaluated using in-vivo studies. The energy dispersive X-ray (EDX) mapping, TEM micrograph, and FTIR spectra of the prepared nanofibers strongly demonstrated well entrapment of Se NPs and VE into scaffolds. An amount of 57% Se NPs and 43% VE were gradually released from PCL/GEL/Se NPs/VE scaffold after 4 days immersion in PBS solution (pH 7.4). The both PCL/GEL/Se NPs and PCL/GEL/Se NPs/VE scaffolds supported 3T3 cell proliferation and attachment as confirmed by MTT assay and SEM imaging. Complete re-epithelialization, low level of edema and inflammatory cells in coordination with high level of oriented collagens demonstrated the wound healing activity of PCL/GEL/Se NPs/VE. Besides, significant antioxidant efficacy of PCL/GEL/Se NPs and PCL/GEL/Se NPs/VE scaffolds was demonstrated according to GSH and MDA assays. To sum up, the prepared PCL/GEL/Se NPs/VE scaffold in the present study represented suitable healing effect on animal model which candidate it for further studies.

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Section: Scaffolds Characterizationmentioning

confidence: 91%

Section: Scaffolds Characterizationmentioning

confidence: 91%

Section: Scaffolds Characterizationmentioning

confidence: 99%

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Bioactive anti-oxidative polycaprolactone/gelatin electrospun nanofibers containing selenium nanoparticles/vitamin E for wound dressing applications

et al. 2021

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“…Antibiotic drugs and composites can be associated with biological dressings to improve their healing activities. Studies involving doxycycline and graphene oxide-associated dressings accelerated wound healing, improving re-epithelialization and collagen remodeling, and enhancing the molecules antibacterial activity [ 85 , 86 ]. Nanotechnologies have been used in dressings for growth factor incorporation, ameliorating growth factors bioavailability and stability.…”

Section: Wound Treatmentsmentioning

confidence: 99%

Cutaneous Wound Healing: An Update from Physiopathology to Current Therapies

Gushiken

Beserra

Bastos

et al. 2021

Life

139

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The skin is the biggest organ of human body which acts as a protective barrier against deleterious agents. When this barrier is damaged, the organism promotes the healing process with several molecular and cellular mechanisms, in order to restore the physiological structure of the skin. The physiological control of wound healing depends on the correct balance among its different mechanisms. Any disruption in the balance of these mechanisms can lead to problems and delay in wound healing. The impairment of wound healing is linked to underlying factors as well as aging, nutrition, hypoxia, stress, infections, drugs, genetics, and chronic diseases. Over the years, numerous studies have been conducted to discover the correct approach and best therapies for wound healing, including surgical procedures and non-surgical treatments such as topical formulations, dressings, or skin substitutes. Thus, this general approach is necessary to facilitate the direction of further studies. This work provides updated concepts of physiological mechanisms, the factors that can interfere, and updated treatments used in skin wound healing.

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“…On the other hand, endogenous enzymatic antioxidants such as superoxide dismutase (SOD), catalase (CAT), and glutathione-Stransferase (GST), in addition to endogenous non-enzymatic antioxidants such as glutathione (GSH), prevent the overproduction of ROS during the early stages of wound healing. When antioxidative defense systems cannot adequately scavenge ROS, oxygen radicals damage cell lipids, proteins, and DNA, causing oxidative stress (Tort et al, 2020;Thi et al, 2020). Nacetylcysteine (NAC) is a thiol compound clinically approved for use as a mucolytic agent (Aldini et al, 2018).…”

Section: Introductionmentioning

confidence: 99%

Düşük Dozda N-Asetilsistein Uygulaması Diyabetik Yara İyileşmesini Hızlandırır mı?

Peker

2021

Erzincan Üniversitesi Fen Bilimleri Enstitüsü Dergisi

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Oxidative stress and persistent inflammation play crucial role in the progression of diabetic wound complications. N-Acetylcysteine (NAC) is an amino acid derivative that promotes wound healing because of its ability of antioxidant properties. The aim of this study was to evaluate the effect of systemic NAC administration on oxidative stress, inflammatory markers, and collagen production in diabetic wound healing. Induction of diabetes was done by intraperitoneally administration of streptozotocin in Wistar rats. A dorsal circular wound was created in diabetic rats. After that subjects were treated with NAC (60 mg/kg) intraperitoneally to evaluate the wound healing potential of NAC. In the wound tissues of diabetic rats, lipid peroxidation and inflammatory markers were significantly increased (p<0.05). Superoxide dismutase and catalase activities, glutathione and NOx levels, and collagen production were significantly reduced in diabetic group (p<0.05). NAC administration increased antioxidant status and NOx levels, reduced lipid peroxidation and inflammatory marker levels in treated diabetic group compared to diabetic group (p<0.05). Additionally, in the diabetic NAC treatment group, collagen production was significantly increased and wound area was significantly smaller than diabetic group (p<0.05). Low dose NAC administration was found to be effective in diabetic wound healing by reducing oxidative stress and inflammation and increasing collagen production.

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The effect of a new wound dressing on wound healing: Biochemical and histopathological evaluation

Cited by 42 publications

References 48 publications

Bioactive anti-oxidative polycaprolactone/gelatin electrospun nanofibers containing selenium nanoparticles/vitamin E for wound dressing applications

Bioactive anti-oxidative polycaprolactone/gelatin electrospun nanofibers containing selenium nanoparticles/vitamin E for wound dressing applications

Cutaneous Wound Healing: An Update from Physiopathology to Current Therapies

Düşük Dozda N-Asetilsistein Uygulaması Diyabetik Yara İyileşmesini Hızlandırır mı?

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