1987
DOI: 10.1111/j.1365-2125.1987.tb03197.x
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The effect of a new inotropic agent, DPI 201‐106, on systolic time intervals and the electrocardiogram in healthy subjects.

Abstract: 1 DPI 201-106 (DPI) is a novel inotropic agent, with Na+ channel agonistic action combined with a sensitization of contractile proteins to Call. In a double-blind trial in healthy volunteers (n = 20) cardiovascular effects (blood pressure, heart rate, ECG) of single oral doses were studied. In addition systolic time intervals (STIs) were assessed in 10 of these subjects. DPI plasma concentrations were measured by h.p.l.c. 2 Preejection period was shortened by 14 ms (P < 0.01) and 30 ms (P < 0.01) 1 h after 30 … Show more

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Cited by 18 publications
(6 citation statements)
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“…Thus, even the 1 h observation period with 10-5mol -1 BDF 9148 in our experiments may have been too short for the development of a biphasic drug effect. However, if the increase of the action potential duration is indeed transient in vivo, this could explain why no increase of the Q-T interval of the ECG is seen in the presence of BDF 9148 (Muster & Raap 1990) while DPI 201-106 usually causes a prolongation (Ruegg & Nuesch, 1987;Kostis et al, 1987).…”
Section: Discussionmentioning
confidence: 99%
“…Thus, even the 1 h observation period with 10-5mol -1 BDF 9148 in our experiments may have been too short for the development of a biphasic drug effect. However, if the increase of the action potential duration is indeed transient in vivo, this could explain why no increase of the Q-T interval of the ECG is seen in the presence of BDF 9148 (Muster & Raap 1990) while DPI 201-106 usually causes a prolongation (Ruegg & Nuesch, 1987;Kostis et al, 1987).…”
Section: Discussionmentioning
confidence: 99%
“…The most pronounced antiarrhythmic effect was prolongation of the Q-T interval of the electrocardiogram (Kostis et al 1987;Rüegg and Nüesch 1987). Prolongation of the Q-T interval may increase incidence of torsade de pointes, a type of malignant arrhythmia which is intermediate between tachycardia and ventricular fibrillation (Fontaine 1992).…”
Section: Insecticides (Binding Site 6)mentioning
confidence: 99%
“…However, synthetic Na + channel agonists have a critical drawback to the clinical application because of the proarrhythmic effect. Most synthetic Na + channel agonists induce a slowing of I Na inactivation and develop a persistent I Na ( Yuill et al ., 2000 ), causing the generation of early after‐depolarization (EAD; Ruegg & Nuesch, 1995 ; Yuill et al ., 2000 ). Such proarrhythmic risk makes these drugs less suitable for clinical application.…”
Section: Introductionmentioning
confidence: 99%