The effect of a sodium lauryl sulfate‐free dentifrice on patients with recurrent oral ulceration

Healy, Claire M.; Paterson, M. E. L.; Joyston-Bechal, S; Williams, Dennis; Thornhill, Martin H.

doi:10.1111/j.1601-0825.1999.tb00062.x

Cited by 37 publications

(24 citation statements)

References 20 publications

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“…However, these were relatively simple dentrifices in which SLS was included with abrasive, humectant, fluoride and flavouring and the differences may reflect the mode of application, tissue structure or the absence of TCN or zinc from the formulation. The choice of ventral tongue for our study reflected a wider investigation of the possible role of SLS in recurrent apthous ulceration (Healy et al, 1999), a disease primarily restricted to non-keratinised oral mucosa and the use of post mortem tissue was influenced by the quantity of tissue required. The suitability of such tissue for permeability studies has previously been validated (Lesch et al, 1989), but clearly it would be interesting to establish whether SLS or SLS/TCN/Zn mixtures had a similar effect on keratinised human oral mucosa.…”

Section: Discussionmentioning

confidence: 99%

The effect of sodium lauryl sulphate, triclosan and zinc on the permeability of normal oral mucosa

2000

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OBJECTIVE: Sodium lauryl sulphate (SLS), an important component in many oral health products, is well established as a contact irritant in skin. Recent studies have suggested that it may also affect the structural integrity of oral mucosa. SLS is rarely used alone in dentifrices or mouthwashes and the aim of this study was to establish the effect of SLS both alone and in combination with Triclosan (TCN) and zinc (Zn) on the permeability barrier properties of normal human oral mucosa. METHOD: Ventral tongue mucosa was obtained from nine males and seven females within 60 h of death and stored frozen at ؊70؇C until use. The permeability of the tissue to tritiated water was measured after pretreatment for 15 min with SLS alone, SLS/TCN, SLS/Zn and a SLS/TCN/Zn mixture. Treatment with distilled water (DW) served as control. The histological appearance of the tissue before and after treatment was also examined by light microscopy. RESULTS: SLS treatment caused a significant increase in water permeability compared to control tissue (Kp ‫؍‬ 11.7 ؎ 1.00; 4.96 ؎ 0.50 respectively; P Ͻ 0.005). Treatment with a SLS/TCN/Zn mixture, however, had no effect on the permeability to water (Kp ‫؍‬ 5.5 ؎ 0.56). Histological examination revealed that tissue exposed to SLS had a marked disruption of the epithelial surface whilst tissue treated with a SLS/TCN/Zn mixture was indistinguishable from controls. CONCLUSION: Although mucosa exposed to SLS alone showed an increase in permeability to water, the addition of TCN and Zn to SLS appeared to prevent this effect. As SLS is included in some dental products to solubilise compounds such as TCN, its presence may have no effect on the permeability barrier property of oral mucosa.

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Section: Discussionmentioning

confidence: 99%

The effect of sodium lauryl sulphate, triclosan and zinc on the permeability of normal oral mucosa

2000

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“…It was proposed that SLS might erode the oral mucin layer, exposing the underlying epithelium, thereby making the individual more susceptible to RAS. This theory still needs further clarification, because it has also been demonstrated that use of SLS-free toothpastes did not affect development of new lesions in RAS patients 52, 53 .…”

Section: Predisposing Etiologic Factorsmentioning

confidence: 99%

Recurrent Aphthous Stomatitis

Akintoye

Greenberg

2014

Dental Clinics of North America

272

216

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Recurrent Aphthous Stomatitis (RAS) is the most common ulcerative disease affecting the oral mucosa. It occurs mostly in healthy individuals and has atypical clinical presentation in immunocompromised individuals. The etiology of RAS is still unknown, but several local, systemic, immunologic, genetic, allergic, nutritional, and microbial factors, as well as immunosuppressive drugs, have been proposed as causative agents. Clinical management of RAS is based on severity of symptoms, frequency, size and number of lesions using topical and systemic therapies. The goals of therapy are to decrease pain and ulcer size, promote healing and decrease frequency of recurrence.

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“…This supposed adverse effect of SLS does not reflect any increased oral retention of SLS (Fakhry‐Smith et al , 1997). However, while another study also suggested that SLS‐free dentifrice might reduce the number of ulcers that patients with RAS might develop (Chahine et al , 1997), a large double‐blind study did not observe any significant change in the frequency or severity of RAS (Healy et al , 1999). In view of the widespread use of SLS in dentifrices it seems unlikely that this agent truly predisposes to, or causes, most RAS.…”

Section: Local Factors Predisposing To Rasmentioning

confidence: 99%

Number VI Recurrent aphthous stomatitis

et al. 2005

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Recurrent aphthous stomatitis (RAS; aphthae; canker sores) is a common condition which is characterized by multiple recurrent small, round or ovoid ulcers with circumscribed margins, erythematous haloes, and yellow or grey floors typically presenting first in childhood or adolescence. RAS occurs worldwide although it appears most common in the developed world. The aetiology of RAS is not entirely clear. Despite many studies trying to identify a causal microorganism, RAS does not appear to be infectious. A genetic predisposition is present, as shown by strong associations with genotypes of IL-1beta; IL-6 in RAS patients, and a positive family history in about one-third of patients with RAS. Haematinic deficiency is found in up to 20% of patients. Cessation of smoking may precipitate or exacerbate RAS in some cases. Ulcers similar to RAS may be seen in human immunodeficiency virus disease and some other immune defects, and drugs, especially non-steroidal anti-inflammatory drugs and nicorandil may produce lesions clinically similar to RAS. Topical corticosteroids can often control RAS. However, the treatment of RAS remains unsatisfactory, as most therapies only reduce the severity of the ulceration and do not stop recurrence.

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The effect of a sodium lauryl sulfate‐free dentifrice on patients with recurrent oral ulceration

Cited by 37 publications

References 20 publications

The effect of sodium lauryl sulphate, triclosan and zinc on the permeability of normal oral mucosa

The effect of sodium lauryl sulphate, triclosan and zinc on the permeability of normal oral mucosa

Recurrent Aphthous Stomatitis

Number VI Recurrent aphthous stomatitis

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