Recurrent Aphthous Stomatitis

Akintoye, Sunday O.; Greenberg, Martin S.

doi:10.1016/j.cden.2013.12.002

Cited by 274 publications

(282 citation statements)

References 90 publications

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“…One hypothesis is that RAS results from a disorder of cell‐mediated immunity, where subsets of proinflammatory cytokines and T cells accumulate 10. Hormonal factors, emotional stress, family history, and trauma may predispose a patient to RAS 8. Dysregulation in cell‐mediated immunity and accumulation of subsets of proinflammatory cytokines and T cells may be linked with cancers 10.…”

Section: Discussionmentioning

confidence: 99%

“…RAS occasionally coincides with genital mucosa; both are characterized by repeated development of one or multiple discrete painful ulcers that usually heal within 7‐14 days 6, 7, 8, 9. Associated lesions are typically circular or oval ulcers 3‐5 mm in length or diameter with a peripheral rim of erythema and a central yellowish adherent exudate.…”

Section: Introductionmentioning

confidence: 99%

“…Associated lesions are typically circular or oval ulcers 3‐5 mm in length or diameter with a peripheral rim of erythema and a central yellowish adherent exudate. Incidents of RAS range in severity; some patients note only an occasional lesion, whereas others experience continual ulcer activity 6, 7, 8, 9. RAS is typically easy to clinically diagnose based on patient history and physical examination.…”

Section: Introductionmentioning

confidence: 99%

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Recurrent aphthous stomatitis may be a precursor or risk factor for specific cancers: A case‐control frequency‐matched study

et al. 2018

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BackgroundRecurrent aphthous stomatitis (RAS) is considered a prophase symptom in patients with specific cancers. This study assessed the association between RAS and subsequent onset of cancer based on a nationwide population‐based database in Taiwan.Materials and MethodsWe selected study participants from the National Health Insurance Research Database from January 2000 to December 2008. Patients in the non‐RAS cohort were matched to case study patients at a 1:1 ratio through frequency matching. All participants were followed up for at least 5 years, and those who received cancer diagnoses during follow‐up were identified.ResultsAmong 52 307 patients with and 52 304 patients without RAS, the combined hazard ratio (HR) of all subsequent cancer cases was 1.3 (95% confidence interval [CI]: 1.25‐1.35, P = 0). RAS diagnosis was associated with risk for cancers of the head and neck (aHR = 2, 95% CI: 1.8‐2.3), colon (aHR = 1.2, 95% CI: 1.1‐1.4), liver (aHR = 1.1, 95% CI: 1‐1.3), pancreas (aHR = 1.4, 95% CI: 1.1‐1.7), skin (aHR = 1.4, 95% CI: 1.2‐1.7), breast (aHR = 1.2, 95% CI: 1.1‐1.4), and prostate (aHR = 1.5, 95% CI: 1.3‐1.8), as well as hematologic cancers (aHR = 1.6, 95% CI: 1.3‐1.9). A higher risk was observed for male patients (aHR = 1.35, 95% CI: 1.28‐1.42) than for female patients (aHR = 1.25, 95% CI: 1.18‐1.31) with RAS.Conclusions RAS was associated with specific cancers. Susceptible RAS patients should be screened for specific cancers.

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Section: Discussionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

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Recurrent aphthous stomatitis may be a precursor or risk factor for specific cancers: A case‐control frequency‐matched study

et al. 2018

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“…1,2 It usually onsets in childhood and affects about 25% of the world population. [3][4][5][6] Its typical lesions are well-circumscribed rounded ulcers surrounded by a peripheral halo of erythema, with a white/yellowish fibromembranous center.…”

Section: Introductionmentioning

confidence: 99%

“…Several factors have been suggested as triggering agents, including local factors, such as local trauma, which is considered an etiological agent of RAS in susceptible patients. 1,7,8 Regarding systemic factors, the infection by H. pylori has been reported as an etiological factor of RAS. 9 The ulcerous colitis and the Crohn's disease have also been associated with the appearance of oral ulcers similar to the ones of RAS.…”

Section: Introductionmentioning

confidence: 99%

Characterization of recurrent aphthous stomatitis in a young population

Oliveira¹,

Coimbra²,

Mesquita³

et al. 2018

j.rpemd

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Aim: To characterize recurrent aphthous stomatitis in a young population and investigate the association between these lesions and predisposing factors, as well as potential modifications in children's daily routines. Methods:The data was collected by delivering a questionnaire to students attending S. Miguel Primary School, in Vizela, as well as to their parents/guardians. A literature review was conducted, using scientific databases such as PubMed, Cochrane and the Virtual Library of the University of Porto.Results: A common prevalence of aphthous ulcers was found in 53.0% of the sample. Most participants reported a number of lesions between 1 and 5, located in the jugal/labial mucosa, healing within 4 to 7 days. About 46.4% of the participants had a family history of this disease, mainly on the mother's side. About 29.6% of the students associated aphthae with traumatic events in the oral mucosa, while 9.8% associated them with stress. A significant association was found only between the frequency of aphthae and gastrointestinal disorders, and not with other factors. A significant use of topical medications was detected, and the pharmacist was the most consulted healthcare professional. Conclusion

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Recurrent Oral Ulcers

Stoopler

Sollecito

2015

JAMA

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A 44-year-old man with a history of gastroesophageal reflux disease and anxiety presents for evaluation of mouth ulcers recurring for the past 2 years. The painful ulcers resolve within 2 weeks but recur on different mucosal surfaces. He denies new medications, foods, or oral hygiene products and involvement of cutaneous or other mucosal surfaces. He is uncertain whether he has a family history of oral ulcers. He was previously prescribed anesthetic rinses and fluconazole, without benefit. His current medications include omeprazole and lorazepam. Intraoral examination demonstrates an ulcer with a pseudomembrane and erythematous halo on the left lateral surface of the tongue (Figure). Physical examination results are otherwise normal.Quiz at jama.com WHAT WOULD YOU DO NEXT?

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Recurrent Aphthous Stomatitis

Cited by 274 publications

References 90 publications

Recurrent aphthous stomatitis may be a precursor or risk factor for specific cancers: A case‐control frequency‐matched study

Recurrent aphthous stomatitis may be a precursor or risk factor for specific cancers: A case‐control frequency‐matched study

Characterization of recurrent aphthous stomatitis in a young population

Recurrent Oral Ulcers

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