The effect of a supersaturated calcium phosphate mouth rinse on the development of oral mucositis in head and neck cancer patients treated with (chemo)radiation

Lambrecht, Maarten; Mercier, Carole; Geussens, Yasmyne; Nuyts, Sandra

doi:10.1007/s00520-013-1829-0

Cited by 28 publications

(25 citation statements)

References 16 publications

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“…For SCPR administered for the treatment of OM in patients receiving RT (with or without CT) for H&N cancer, there was 1 RCT [30] showing no efficacy. There was also 1 comparative study showing ineffectiveness [31].…”

Section: Supersaturated Calcium Phosphate Rinse: Rt-ct-prevention Guimentioning

confidence: 99%

Systematic review of natural and miscellaneous agents for the management of oral mucositis in cancer patients and clinical practice guidelines—part 1: vitamins, minerals, and nutritional supplements

Yarom

Hovan²,

Bossi

et al. 2019

Support Care Cancer

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Purpose To update the clinical practice guidelines for the use of natural and miscellaneous agents for the prevention and/or treatment of oral mucositis (OM). Methods A systematic review was conducted by the Mucositis Study Group of the Multinational Association of Supportive Care in Cancer / International Society of Oral Oncology (MASCC/ISOO). The body of evidence for each intervention, in each cancer treatment setting, was assigned an evidence level. The findings were added to the database used to develop the 2014 MASCC/ ISOO clinical practice guidelines. Based on the evidence level, the following guidelines were determined: Recommendation, Suggestion, and No Guideline Possible. Results A total of 78 papers were identified within the scope of this section, out of which 29 were included in this part, and were analyzed with 27 previously reviewed studies. A new Suggestion was made for oral glutamine for the prevention of OM in head and neck (H&N) cancer patients receiving radiotherapy with concomitant chemotherapy. The previous Recommendation against the use of parenteral glutamine for the prevention of OM in hematopoietic stem cell transplantation (HSCT) patients was reestablished. A previous Suggestion for zinc to prevent OM in H&N cancer patients treated with radiotherapy or chemoradiotherapy was reversed to No Guideline Possible. No guideline was possible for other interventions. Conclusions Of the vitamins, minerals, and nutritional supplements studied for the management of OM, the evidence supports a Recommendation against parenteral glutamine in HSCT patients and a Suggestion in favor of oral glutamine in H&N cancer patients for the management of OM.

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Section: Supersaturated Calcium Phosphate Rinse: Rt-ct-prevention Guimentioning

confidence: 99%

Systematic review of natural and miscellaneous agents for the management of oral mucositis in cancer patients and clinical practice guidelines—part 1: vitamins, minerals, and nutritional supplements

Yarom

Hovan²,

Bossi

et al. 2019

Support Care Cancer

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“…Extensive professional support will provide the patient with greater confidence and cooperation that will positively reflect in the final treatment outcome. 6…”

Section: Resultsmentioning

confidence: 99%

“…So we can quickly cite and define the main complications of radiotherapy and chemotherapy for head and neck cancer. 6…”

Section: Mini Reviewmentioning

confidence: 99%

The problem of head and neck cancer and its treatment

Pereira

2018

JDHODT

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The oral cancer is predominant in developing countries, particularly in lower socioeconomic sectors. Surgery, radiotherapy and chemotherapy are the therapeutic modalities used in the treatment of head and neck cancer. They can be used alone or together. Radiation therapy causes lesions in normal tissues located in the radiation field. The resulting oral sequelae can cause substantial problems during and after radiation therapy and are the major determining factors in patients' quality of life. The most serious and debilitating complications of radiotherapy are mucositis candidiasis and osteoradionecrosis.

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“…Three studies used active control agents (soybean or fluoride) and possibly biased outcomes ( Papas et al, 2003 ; Lin et al, 2010 ; Lin et al, 2006 ). One study transferred four participants to the treatment group, potentially overcounting outcomes in the exposed group (misclassification differential bias) ( Lambrecht et al, 2013 ). One study transferred patient files to the sponsor who then monitored outcomes (conflict of interest) ( Buntzelet al, 2010 ).…”

Section: Resultsmentioning

confidence: 99%

Mineral derivatives in alleviating oral mucositis during cancer therapy: a systematic review

Lee

2015

PeerJ

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Objectives. Oral mucositis (mouth ulcers) is a cancer therapy side effect. Costly treatment interventions are often neglected in favor of cost-effective agents. This review assessed the general efficacy of mineral derivatives (a cost-effective agent) in alleviating oral mucositis (OM) during cancer therapy compared to the standard care, or placebo—including a decision tree to aide healthcare workers.Data Sources. Electronic searches of MEDLINE via OVID, EMBASE, CENTRAL, CANCERLIT via PubMed, and CINAHL via EBSCO (year 2000 to 11 September 2014) were undertaken for randomised controlled trials. A meta-search strategy extracted content from aggregate online databases.Review Methods. Randomized controlled trials were assessed (participants, intervention, outcome, results, and risk of bias) for inclusion. The author abstracted binary and continuous data synthesised to Hedges’ g in a random effects model. The primary outcome measures were severity (incidence of peak oral mucositis, duration of oral mucositis, and time to onset); secondary outcome measures were the incidence of pain, and analgesic use. Serum mineral levels, total parenteral nutrition, and adverse events were discussed. The decision tree was mapped using sensitivity, specificity, pre-test and post-test Bayesian probability.Results. 1027 citations were identified and 16 studies were included (n = 1120; mean age 49 years). Cancer therapies consisted of chemotherapy, radiotherapy, chemo-radiotherapy, or hematopoietic stem cell transplantation. Outcome mineral derivatives were zinc (n = 549), calcium phosphate (n = 227), povidone-iodine (n = 228), or selenium (n = 116). Severity was measured across variable OM grading systems: In 13 studies, individuals in treatment groups (n = 958) experienced peak OM less than controls (g = −0.47, 95% CI −0.7 to −0.2, p = 0.0006); time to OM onset was significantly delayed in treatment than controls (g = −0.51, 95% CI−0.8 to −0.2, p = 0.0002; five studies); OM mean duration, pain incidences, or analgesics use was not significant. The decision analysis favored selenium.Conclusion. The general positive effect trend suggests individuals taking mineral derivatives during cancer therapies are less likely to experience peak OM than those without. However, significant bias and heterogeneity indicates the need for developing further methods in account of diverse protocols and include novel recordings (serum mineral levels and cell signals) in estimating a uniform true effect.

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The effect of a supersaturated calcium phosphate mouth rinse on the development of oral mucositis in head and neck cancer patients treated with (chemo)radiation

Abstract: In this randomized study, the addition of CP mouth rinse to standard of care did not improve the frequency, duration or severity of the most common acute toxicities during and early after (chemo)radiation. There is currently no evidence supporting its standard use in daily practice.

Cited by 28 publications

References 16 publications

Systematic review of natural and miscellaneous agents for the management of oral mucositis in cancer patients and clinical practice guidelines—part 1: vitamins, minerals, and nutritional supplements

Systematic review of natural and miscellaneous agents for the management of oral mucositis in cancer patients and clinical practice guidelines—part 1: vitamins, minerals, and nutritional supplements

The problem of head and neck cancer and its treatment

Mineral derivatives in alleviating oral mucositis during cancer therapy: a systematic review

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