The effect of acemannan sponges in post-extraction socket healing: A randomized trial

Jansisyanont, Pornchai; Tiyapongprapan, Sorapon; Chuenchompoonut, Vannaporn; Sangvanich, Polkit; Thunyakitpisal, Pasutha

doi:10.1016/j.ajoms.2015.07.006

Cited by 21 publications

(26 citation statements)

References 33 publications

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“…Acemannan, the major polysaccharide fraction from Aloe vera, has been reported as a promising biomaterial for bone regeneration [8]. Acemannan has shown osteoinductive effects, enhancing the alveolar bone and bone density in tooth extraction sockets [9,10]. However, the radiographic and histological evaluation of acemannan on bone formation in direct sinus lift surgery has not been investigated.…”

Section: Introductionmentioning

confidence: 99%

“…In this study, acemannan was extracted from fresh Aloe vera pulp gel and characterized with 13 C-and 1 H-nuclear magnetic resonance spectroscopy and Fourier transform infrared spectroscopy as previously described [11,12]. The acemannan sponge was prepared by dissolved 150 mg acemannan in 3 ml sterile distilled water, frozen at -80°C overnight, and then lyophilized for 24 h [10]. The sponge was sterilized by gamma irradiation (Thailand Institute of Nuclear Technology, Bangkok, Thailand) and stored in a desiccator until used.…”

Section: Introductionmentioning

confidence: 99%

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Acemannan Induced Bone Regeneration in Lateral Sinus Augmentation Based on Cone Beam Computed Tomographic and Histopathological Evaluation

Trinh

Dam

Banlunara

et al. 2020

Case Reports in Dentistry

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Acemannan, the major polysaccharide extracted from Aloe vera, is biomaterial that has demonstrated osteoinductive effects in vitro and in vivo. However, the effect of acemannan sponges on bone formation in open-type sinus augmentation has not evaluated. Here, we report a case study using radiographic and histological analyses to investigate the effect of acemannan on bone formation after lateral sinus lift surgery. The case was a 57-year-old female patient with an atrophic left posterior maxilla who underwent lateral sinus lift using an acemannan sponge using the two-stage procedure. In the first stage, an acemannan sponge was inserted through the bony window and placed between the antral floor and the elevated sinus membrane. Cone beam computed tomography (CBCT) images were taken immediately as baseline and 6-month postoperation for evaluation. A bone core specimen was also obtained for histological examination at the time of implant placement. The histological results revealed new bone formation, and the CBCT images demonstrated increased alveolar bone height at 6-month postoperation. Our findings suggest that an acemannan sponge could be a biomaterial for inducing bone formation in sinus lift surgery.

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Section: Introductionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Acemannan Induced Bone Regeneration in Lateral Sinus Augmentation Based on Cone Beam Computed Tomographic and Histopathological Evaluation

Trinh

Dam

Banlunara

et al. 2020

Case Reports in Dentistry

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“…Using the results from earlier studies 19 , 20 and with a type I error of 5% and a power of 0.80, a sample size of 7 subjects for each group was required to demonstrate significant differences between the groups. The sample size of each group was adjusted to 8 considering the possibility of a 10% patient attrition rate.…”

Section: Methodsmentioning

confidence: 99%

“…The regenerative effect of acemannan in hard tissue and soft tissue has been intensively studied. 18 , 19 , 20 , 21 , 22 , 23 No fibrous capsule or ankylosis was reported when implanting acemannan sponges in calvaria defects, tooth extraction sockets, pulp capping, and class II furcation defects. Therefore, acemannan is a potential biomolecule for periapical defect healing that requires complex periodontal ligament and alveolar bone regeneration in the periodontium.…”

Section: Introductionmentioning

confidence: 99%

Acemannan induces rapid early osseous defect healing after apical surgery: A 12-month follow-up of a randomized controlled trial

Van

Thu

Sangvanich

et al. 2020

Journal of Dental Sciences

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Background/purpose Acemannan is an osteoinductive material. This study's objective was to compare the outcomes of bone defect healing using 3-dimensional images after apical surgery with or without adding acemannan sponges. Materials and methods Twenty-two anterior teeth from 9 males and 13 females requiring apical surgery were included in this randomized controlled trial. Post-surgery, the bone defects were randomly divided into three groups: blood clot control, 5-, or 10-mg acemannan sponge groups. CBCT scans were taken immediately (baseline), 3-, 6-, and 12-month post-surgery. Sagittal serial sections (1 mm thick slices parallel to the long axis of the tooth) of the defect image were created. The defect boundary was located and the total bone defect volume (BDV) was calculated from the sum of the volume of the serial defect sections. The bone healing was assessed by the percentage of total bone defect volume reduction (%ΔBDV). The paired t-test and one-way ANOVA were used to analyze the differences within each group and between groups, respectively. Results The baseline mean BDV of the control, 5-, and 10-mg acemannan groups were not significantly different ( p > 0.05). After treatment, the mean BDV for each group was reduced in a time-dependent manner. Compared with the control group, the 5- and 10-mg acemannan groups had a significantly greater %ΔBDV (approximately 2- and 1.89-fold) at 3-months post-surgery, respectively ( p < 0.05). However, at the 6- and 12- month follow-up, the %ΔBDV was not significantly different between the groups. Conclusion These data suggest acemannan enhanced early bone healing after apical surgery.

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“…The authors concluded acetyl-groups affect ACM's structure and physical/biological properties. Jansisyanont et al [9] investigated the effect of ACM on tooth socket healing, 3 months after surgical removal of mandibular partial bony impacted third molars. ACM is a safe biomaterial for post-extraction alveolar bone ridge preservation.…”

Section: Aloe Vera Scaffolds For Biomedical Applicationsmentioning

confidence: 99%

Nutraceutical Aloe Vera Gel Scaffolds for Supporting a Healthy Muscle Movement

Yagi

Hasegawa

Mikami³

et al. 2018

Journal of Gastroenterology and Hepatology Research

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The efficacy for pain and stiffness associated with arthralgia of the knee and hip was evaluated based on locomotive syndrome risk test. Furthermore, w-3polyunsaturated fatty acids (EPA and DHA) and L-Arginine with AVJ revealed a possible dietary efficacy for Parkinson's disease (PD) patients at stage 3. Prophylactic possible efficacies of AVJ as bio-functional scaffolds are fully expected for increasing collagen synthesis in knee and/or hip joint healing and for mitigation of risk factors of PD patients with diabetes.

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The effect of acemannan sponges in post-extraction socket healing: A randomized trial

Cited by 21 publications

References 33 publications

Acemannan Induced Bone Regeneration in Lateral Sinus Augmentation Based on Cone Beam Computed Tomographic and Histopathological Evaluation

Acemannan Induced Bone Regeneration in Lateral Sinus Augmentation Based on Cone Beam Computed Tomographic and Histopathological Evaluation

Acemannan induces rapid early osseous defect healing after apical surgery: A 12-month follow-up of a randomized controlled trial

Nutraceutical Aloe Vera Gel Scaffolds for Supporting a Healthy Muscle Movement

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