The Effect of Acetaminophen on Physical, Compression Strength and Thermal Behaviours of Kelcogel Hydrogel Films

Ramli, Noor Fadhilah; Razak, Saiful Izwan Abd; Amin, Khairul Anuar Mat

doi:10.1088/1757-899x/440/1/012026

Cited by 1 publication

(1 citation statement)

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“…For antipyretic actions, acetaminophen reduces the human body temperature by acting on the hypothalamus; a part of the brain that control body temperature 11 . Acetaminophen can also be loaded into a drug holder, such as hydrogel 12 for drug delivery application. Factors that can affect the kinetic release of drugs are the nature of the polymer, percentage of drugs loaded into the polymer, the interaction between drugs and polymer as well as pH value of targeted medium.…”

Section: Introductionmentioning

confidence: 99%

Kinetic Release of Acetaminophen from Cross-Linked Carrageenan Hydrogel for Wound Dressing Application

Kasmi¹,

Zailani²,

Bakar³

et al. 2020

J. Pure Appl. Microbiol.

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This study investigates the compressive strength, water vapor transmission rates (WVTRs), and swelling rate of the Carrageenan (CR) hydrogel. Carrageenan hydrogel with addition of 40 mM CaCl 2 (CR4) shows the optimum compressive strength (7.06 kPa), ideal WVTRs (1918 ± 17 g m -2 h -1 ) and better swelling behavior compared to low concentration of CaCl 2 . The CR4 hydrogel was further incorporated with acetaminophen (APAP) and the properties of the hydrogel were examined. The compressive strength results show the addition of APAP into CR4 hydrogel improved the stress of CR-APAP3 (CR hydrogel with 60% (w/w) of APAP) hydrogel to 10.07 kPa than CR-APAP1 (CR hydrogel with 20% (w/w) of APAP) at 7.41 kPa. The WVTR values increased as the concentration of APAP loaded into CR hydrogel increased. The swelling rates of CR-APAP were low at all concentrations of APAP-loaded which was at 14.5%. Kinetic release of CR-APAP hydrogel was improved in which, the CR-APAP1 released almost 75% within the first 8-min, while CR-APAP2 was 40% released within the first 12-min, and CR-APAP3 released 30% within the first 13-min. In other word, it shows that higher concentration of APAP in CR prolonged the release of drug. Overall, the CR-APAP hydrogel is suitable to be applied as degradable wound dressing materials and hence, further improve patient compliance due to its fast-release behavior.

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Section: Introductionmentioning

confidence: 99%