The Effect of Acute Hypercalcemia on the Insulin Response to OGTT

Brauman, A; Gilboa, Y.; Hertzeanu, I

doi:10.1055/s-2007-1018671

Cited by 2 publications

(1 citation statement)

References 7 publications

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“…In investigation in vivo in humans hypercalcaemia induced by the intravenous administration of 15 mg Ca/kg body weight is manifested by stimulation of insulin secretion (Gedik et al, 1980). After an intravenous load of 25 mg Ca/kg body weight insulin secretion is inhibited (Brauman et al, 1983). It is not clear whether in this case hypercalcaemia directly inhibits secretion of beta-cells or whether the inhibitory effect of endogenous calcitonin is involved, which is promptly released during hypercalcaemia (Vora et al, 1978).…”

Section: Methodsmentioning

confidence: 99%

The Effects of Calcitonin, Somatostatin and Hypercalcaemia on Metabolic and Hormonal Indicators during an Oral Glucose Tolerance Test (OGTT)

Žofková¹,

Nedvı́dková²,

Stárka³

et al. 2009

Exp Clin Endocrinol Diabetes

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Section: Methodsmentioning

confidence: 99%

The Effects of Calcitonin, Somatostatin and Hypercalcaemia on Metabolic and Hormonal Indicators during an Oral Glucose Tolerance Test (OGTT)

Žofková¹,

Nedvı́dková²,

Stárka³

et al. 2009

Exp Clin Endocrinol Diabetes

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Derangement of glucose metabolism in hyperparathyroidism

Procopio

Borretta

2003

J Endocrinol Invest

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The derangement of glucose metabolism is found frequently in all forms of hyperparathyroidism. Both in primary (PHPT) and secondary hyperparathyroidism (SHPT) PTH excess is thought to be involved in deteriorating insulin sensitivity and secretion though their different clinical and pathophysiological conditions. In PHPT these abnormalities are related to a high frequency of Type 2 diabetes mellitus and also impaired glucose tolerance according to recent clinical studies, without differences between symptomatic and asymptomatic clinical presentation. In chronic renal failure (CRF), the disorders of glucose metabolism due to SHPT do not bear an increased risk for diabetes whereas they seem to be involved in the progression of atherosclerotic vascular damage which connotes CRF. Moreover, clinical and experimental studies have shown that vitamin D deficiency associated with glucose metabolism abnormalities favors the development of the metabolic syndrome. The potential for metabolic and cardiovascular harm related to hyperparathyroidism, especially PHPT, is the most interesting issue for clinical endocrinologists. This short review of the clinical and pathophysiological data of literature on glucose homeostasis disorders in hyperparathyroidism focuses on its potential clinical and therapeutic impact, particularly in the management of PHPT.

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The Effect of Acute Hypercalcemia on the Insulin Response to OGTT

Cited by 2 publications

References 7 publications

The Effects of Calcitonin, Somatostatin and Hypercalcaemia on Metabolic and Hormonal Indicators during an Oral Glucose Tolerance Test (OGTT)

The Effects of Calcitonin, Somatostatin and Hypercalcaemia on Metabolic and Hormonal Indicators during an Oral Glucose Tolerance Test (OGTT)

Derangement of glucose metabolism in hyperparathyroidism

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