The effect of acute swimming exercise on plasma leptin in rats

Baltacı, Abdülkerim Kasım; Vurucu, N; Uzun, Ahmet Okan; Moğulkoç, Rasim; Kılıç, Mehmet

doi:10.4149/bll_2012_132

Cited by 5 publications

(8 citation statements)

References 19 publications

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“…This is supported by a study by Pagano et al (1999) that reported a strong relationship between swimming exercise and circulating leptin, in which plasma leptin was decreased by up to 30 % following exercise in normal rats. Many other animal studies (Baltaci et al 2012) as well as reports on swimmers and marathoners (Karamouzis et al 2002, Zaccaria et al 2002 have noted reduced plasma leptin levels immediately after exercise. However, there are some studies that found either increased concentrations (Flores et al 2006, Zareian et al 2011 or no changes in plasma leptin levels after exercise (Borg et al 2014).…”

Section: Vol 65mentioning

confidence: 87%

“…Recent studies have demonstrated a connection between the HPA axis and adipose tissue (Hernandez et al 2000, Pralong andGaillard 2001). There is also evidence that several peripheral metabolic markers, such as leptin and ghrelin, are altered by stressful events such as maternal separation (Salzmann et al 2004, Schmidt et al 2006 as well as physical stress (Baltaci et al 2012, Zareian et al 2011. However, the effects of physical and social stress on stress and metabolic hormones are extremely variable.…”

Section: Introductionmentioning

confidence: 99%

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The Effect of Neonatal Maternal Stress on Plasma Levels of Adrenocorticotropic Hormone, Corticosterone, Leptin, and Ghrelin in Adult Male Rats Exposed to Acute Heterotypic Stressor

Holubová¹,

Štofková²,

Jurčovičová³

et al. 2016

Physiol Res

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Activation of the hypothalamic-pituitary-adrenal (HPA) axis is important for maintenance of homeostasis during stress. Recent studies have shown a connection between the HPA axis and adipose tissue. The present study investigated the effect of acute heterotypic stress on plasma levels of adrenocorticotropic hormone (ACTH), corticosterone (CORT), leptin, and ghrelin in adult male rats with respect to neonatal maternal social and physical stressors. Thirty rat mothers and sixty of their male progeny were used. Pups were divided into three groups: unstressed control (C), stressed by maternal social stressor (S), stressed by maternal social and physical stressors (SW). Levels of hormones were measured in adult male progeny following an acute swimming stress (10 min) or no stress. ELISA immunoassay was used to measured hormones. The ACTH and CORT levels were significantly increased in all groups of adult progeny after acute stress; however, CORT levels were significantly lower in both neonatally stressed groups compared to controls. After acute stress, plasma leptin levels were decreased in the C and SW groups but increased in the S group. The data suggest that long-term neonatal stressors lead to lower sensitivity of ACTH receptors in the adrenal cortex, which could be a sign of stress adaptation in adulthood. Acute stress in adult male rats changes plasma levels of leptin differently relative to social or physical neonatal stressors.

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Section: Vol 65mentioning

confidence: 87%

Section: Introductionmentioning

confidence: 99%

The Effect of Neonatal Maternal Stress on Plasma Levels of Adrenocorticotropic Hormone, Corticosterone, Leptin, and Ghrelin in Adult Male Rats Exposed to Acute Heterotypic Stressor

Holubová¹,

Štofková²,

Jurčovičová³

et al. 2016

Physiol Res

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“…Similar to the different responses seen in myokines due to exercise, these differences are also observed in relation to adipokines. In this regard, exercise appears to be an effective intervention for decreasing leptin, with many studies reporting a decrease in leptin after acute exercise [ 215 – 221 , 205 ]. In general, these studies showed that high-intensity exercises of 70–95% VO 2 max and resistance exercises with an intensity of 60–80% 1RM (3 sets of 12 repetitions) can be effective in decreasing leptin by 12–26% [ 215 – 221 ].…”

Section: Acute and Chronic Exercise Effects On Exerkinesmentioning

confidence: 99%

“…In this regard, exercise appears to be an effective intervention for decreasing leptin, with many studies reporting a decrease in leptin after acute exercise [ 215 – 221 , 205 ]. In general, these studies showed that high-intensity exercises of 70–95% VO 2 max and resistance exercises with an intensity of 60–80% 1RM (3 sets of 12 repetitions) can be effective in decreasing leptin by 12–26% [ 215 – 221 ]. Leptin levels seem to decrease after acute exercise for up to 12 h and in some studies for up to 24 h [ 215 – 221 ].…”

Section: Acute and Chronic Exercise Effects On Exerkinesmentioning

confidence: 99%

Highlighting the idea of exerkines in the management of cancer patients with cachexia: novel insights and a critical review

Ahmadi Hekmatikar,

Nelson,

Petersen

2023

BMC Cancer

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Background Exerkines are all peptides, metabolites, and nucleic acids released into the bloodstream during and after physical exercise. Exerkines liberated from skeletal muscle (myokines), the heart (cardiokines), liver (hepatokines), white adipose tissue (adipokines), brown adipose tissue (batokines), and neurons (neurokines) may benefit health and wellbeing. Cancer-related cachexia is a highly prevalent disorder characterized by weight loss with specific skeletal muscle and adipose tissue loss. Many studies have sought to provide exercise strategies for managing cachexia, focusing on musculoskeletal tissue changes. Therefore, understanding the responses of musculoskeletal and other tissue exerkines to acute and chronic exercise may provide novel insight and recommendations for physical training to counteract cancer-related cachexia. Methods For the purpose of conducting this study review, we made efforts to gather relevant studies and thoroughly discuss them to create a comprehensive overview. To achieve this, we conducted searches using appropriate keywords in various databases. Studies that were deemed irrelevant to the current research, not available in English, or lacking full-text access were excluded. Nevertheless, it is important to acknowledge the limited amount of research conducted in this specific field. Results In order to obtain a comprehensive understanding of the findings, we prioritized human studies in order to obtain results that closely align with the scope of the present study. However, in instances where human studies were limited or additional analysis was required to draw more robust conclusions, we also incorporated animal studies. Finally, 295 studies, discussed in this review. Conclusion Our understanding of the underlying physiological mechanisms related to the significance of investigating exerkines in cancer cachexia is currently quite basic. Nonetheless, this demonstrated that resistance and aerobic exercise can contribute to the reduction and control of the disease in individuals with cancer cachexia, as well as in survivors, by inducing changes in exerkines.

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“…The changes in leptin levels may depend upon either exercise intensity/ duration or body mass changes [ 59 , 62 ]. Decreased leptin levels corresponded to decreased adiposity after exercise training, however leptin levels have also been shown to fall in response to acute exercise independent of changes in adiposity [ 11 , 151 , 208 ]. In any case, a decrease in leptin would not be in agreement with the activity profile exhibited by either POMC or NPY/AgRP neurons after exercise [ 97 ].…”

Section: Exercise Training Exerts Complex Adaptive Responses In the Amentioning

confidence: 99%

Effects of metabolic state on the regulation of melanocortin circuits

Lieu

Chau

Afrin

et al. 2020

Physiology & Behavior

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Dysfunction in neurophysiological systems that regulate food intake and metabolism are at least partly responsible for obesity and related comorbidities. An important component of this process is the hypothalamic melanocortin system, where an imbalance can result in severe obesity and deficits in glucose metabolism. Exercise offers many health benefits related to cardiovascular improvements, hunger control, and blood glucose homeostasis. However, the molecular mechanism underlying the exercise-induced improvements to the melanocortin system remain undefined. Here, we review the role of the melanocortin system to sense hormonal, nutrient, and neuronal signals of energy status. This information is then relayed onto secondary neurons in order to regulate physiological parameters, which promote proper energy and glucose balance. We also provide an overview on the effects of physical exercise to induce biophysical changes in the melanocortin circuit which may regulate food intake, glucose metabolism and improve overall metabolic health.

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The effect of acute swimming exercise on plasma leptin in rats

Cited by 5 publications

References 19 publications

The Effect of Neonatal Maternal Stress on Plasma Levels of Adrenocorticotropic Hormone, Corticosterone, Leptin, and Ghrelin in Adult Male Rats Exposed to Acute Heterotypic Stressor

The Effect of Neonatal Maternal Stress on Plasma Levels of Adrenocorticotropic Hormone, Corticosterone, Leptin, and Ghrelin in Adult Male Rats Exposed to Acute Heterotypic Stressor

Highlighting the idea of exerkines in the management of cancer patients with cachexia: novel insights and a critical review

Effects of metabolic state on the regulation of melanocortin circuits

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