The effect of acute swimming exercise on plasma melatonin levels in rats

Uzun, Ahmet Okan; Baltacı, Abdülkerim Kasım; Kılıç, Mehmet; Moğulkoç, Rasim

doi:10.4149/bll_2012_015

Cited by 3 publications

(3 citation statements)

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“…This was observed decades ago. For example, forced swimming or cold stressing rats increased their melatonin production via an elevated SNAT activity to match the external stressors [123,124,125,126]. In food-restricted rats high levels of melatonin also were detected [127]; this was also found in a non-human primate, the monkeys [128].…”

Section: Melatonin An Inducible Antioxidantmentioning

confidence: 99%

Melatonin as a Potent and Inducible Endogenous Antioxidant: Synthesis and Metabolism

et al. 2015

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Abstract:Melatonin is a tryptophan-derived molecule with pleiotropic activities. It is present in almost all or all organisms. Its synthetic pathway depends on the species in which it is measured. For example, the tryptophan to melatonin pathway differs in plants and animals. It is speculated that the melatonin synthetic machinery in eukaryotes was inherited from bacteria as a result of endosymbiosis. However, melatonin's synthetic mechanisms in microorganisms are currently unknown. Melatonin metabolism is highly complex with these enzymatic processes having evolved from cytochrome C. In addition to its enzymatic degradation, melatonin is metabolized via pseudoenzymatic and free radical interactive processes. The metabolic products of these processes overlap and it is often difficult to determine which process is dominant. However, under oxidative stress, the free radical interactive pathway may be featured over the others. Because of the complexity of the melatonin degradative processes, it is expected that additional novel melatonin metabolites will be identified in future investigations. The original and primary function of melatonin in early life forms such as in unicellular organisms was as a free radical scavenger and antioxidant. During evolution, melatonin was selected as a signaling molecule to transduce the environmental photoperiodic information into an endocrine message in multicellular organisms and for other purposes as well. As an antioxidant, melatonin exhibits several unique features which differ from the classic antioxidants. These include its cascade reaction with free radicals and its capacity to be induced under moderate oxidative stress. These OPEN ACCESSMolecules 2015, 20 18887 features make melatonin a potent endogenously-occurring antioxidant that protects organisms from catastrophic oxidative stress.

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Section: Melatonin An Inducible Antioxidantmentioning

confidence: 99%

Melatonin as a Potent and Inducible Endogenous Antioxidant: Synthesis and Metabolism

et al. 2015

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“…The early, successful distribution of melatonin via horizontal gene transfers may accentuate the preponderant reliance on this ancient molecule for protection against endogenous and exogenous stress in all eukaryotes and bacteria tested [ 140 , 141 , 142 , 143 , 144 ]. Similar to the induction of prions in yeast as a response to stress, unfavorable exogenous or endogenous conditions such as oxidative stress, nutrient deprivation, and fluctuations in temperature and pH also induce increased production of melatonin in plants [ 145 , 146 , 147 , 148 ] and animals [ 149 , 150 , 151 , 152 , 153 ]. It has been proposed that a high reserve/maximum capacity of melatonin synthesis in humans provides a higher level of survival fitness as effective adaptation to unpredicted internal and external environmental stressors while enhancing recovery rates from injury and external pathogenic attacks [ 154 , 155 ].…”

Section: Liquid–liquid Phase Separation May Regulate Prion Conversion...mentioning

confidence: 99%

Melatonin: Regulation of Prion Protein Phase Separation in Cancer Multidrug Resistance

Loh¹,

Reíter

2022

Molecules

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The unique ability to adapt and thrive in inhospitable, stressful tumor microenvironments (TME) also renders cancer cells resistant to traditional chemotherapeutic treatments and/or novel pharmaceuticals. Cancer cells exhibit extensive metabolic alterations involving hypoxia, accelerated glycolysis, oxidative stress, and increased extracellular ATP that may activate ancient, conserved prion adaptive response strategies that exacerbate multidrug resistance (MDR) by exploiting cellular stress to increase cancer metastatic potential and stemness, balance proliferation and differentiation, and amplify resistance to apoptosis. The regulation of prions in MDR is further complicated by important, putative physiological functions of ligand-binding and signal transduction. Melatonin is capable of both enhancing physiological functions and inhibiting oncogenic properties of prion proteins. Through regulation of phase separation of the prion N-terminal domain which targets and interacts with lipid rafts, melatonin may prevent conformational changes that can result in aggregation and/or conversion to pathological, infectious isoforms. As a cancer therapy adjuvant, melatonin could modulate TME oxidative stress levels and hypoxia, reverse pH gradient changes, reduce lipid peroxidation, and protect lipid raft compositions to suppress prion-mediated, non-Mendelian, heritable, but often reversible epigenetic adaptations that facilitate cancer heterogeneity, stemness, metastasis, and drug resistance. This review examines some of the mechanisms that may balance physiological and pathological effects of prions and prion-like proteins achieved through the synergistic use of melatonin to ameliorate MDR, which remains a challenge in cancer treatment.

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“…Essa redução do VEGF em função do exercício aeróbico já foi demonstrado em algumas patologias como em tumores de camundongos com câncer de mama (Shalamzari et al, 2014) e pacientes pós-infarto (Miyazaki et al, 2001;Barger et al, 2004). Em modelos animais, o nível de melatonina plasmática sofreu uma depressão aguda imediatamente após o exercício aquático, porém sua concentração aumenta significativamente após 24 horas retornando aos valores pré-exercício 48 horas após o término do protocolo (Uzun et al, 2012). Corroborando com nossos resultados, do efeito do exercício físico sobre a concentração plasmática de melatonina, têm sido descritos níveis mais altos em indivíduos saudáveis (Lee et al, 2014) e com distúrbios do sono submetidos a treinamento físico (Cai et al, 2014) ou em atletas jovens (Díaz et al, 1993) e adultos ciclistas (Serrano et al, 2010).…”

Section: Fabio Bessa Melo De Souzaunclassified

O efeito do exercício aeróbico aquático na hemartrose experimental induzida em ratos

Souza¹

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AGRADECIMENTOSÀ minha orientadora Profa. Dra. Suzana Beatriz Veríssimo de Mello, que foi A regente deste projeto. Abriu todas as portas necessárias para que ele fosse executado e sempre se mostrou disposta a me ajudar nessa longa jornada.À Profa. Dra. Clarice Tanaka, que, literalmente, me levou pelas mãos até a Pós-Graduação para apresentar o primeiro rascunho deste projeto.Toda a minha bagagem acadêmica necessária para iniciar a etapa de Doutorado foi construída por meio das experiências didáticas e em pesquisa que me ofereceu. Considero-a como minha "madrinha" dentro da

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The effect of acute swimming exercise on plasma melatonin levels in rats

Cited by 3 publications

References 11 publications

Melatonin as a Potent and Inducible Endogenous Antioxidant: Synthesis and Metabolism

Melatonin as a Potent and Inducible Endogenous Antioxidant: Synthesis and Metabolism

Melatonin: Regulation of Prion Protein Phase Separation in Cancer Multidrug Resistance

O efeito do exercício aeróbico aquático na hemartrose experimental induzida em ratos

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