The effect of adenotonsilectomy on ghrelin, leptin, IGF-1 levels and growth parameters in children with adenotonsillar hypertrophy

Salman, Nergis; Öztürk, Gülfer; Akın, İstemihan; Kılıçaslan, Saffet; Demirel, Fatma; Delibaş, Namık

doi:10.1515/jpem-2013-0367

Cited by 11 publications

(13 citation statements)

References 7 publications

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Section: Obstructive Sleep Apnea and Cardiometabolic Riskmentioning

confidence: 99%

“…However, OSA also predisposes to the worsening of obesity due to daytime sleepiness, decreased physical activity, and neuroendocrine changes, such as resistance to the anorexigenic hormone leptin;405–407 data regarding associations between OSA and levels of the orexigenic hormone ghrelin in children are inconsistent 406,407. Treatment of OSA (primarily T&A, but CPAP in one study) may improve leptin and possibly ghrelin levels, although again, data are somewhat contradictory 407. However, despite these favorable changes, treatment of OSA in children does not necessarily lead to weight loss; as in adults, a number of studies have reported post-T&A weight gain in children and adolescents,408,409 likely due to a reduction in energy expenditure during sleep as well as other hormonal changes.…”

Section: Obstructive Sleep Apnea and Cardiometabolic Riskmentioning

confidence: 99%

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Role of sleep quality in the metabolic syndrome

Koren¹,

Dumin²,

Gozal³

2016

DMSO

152

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Emerging evidence has assigned an important role to sleep as a modulator of metabolic homeostasis. The impact of variations in sleep duration, sleep-disordered breathing, and chronotype to cardiometabolic function encompasses a wide array of perturbations spanning from obesity, insulin resistance, type 2 diabetes, the metabolic syndrome, and cardiovascular disease risk and mortality in both adults and children. Here, we critically and extensively review the published literature on such important issues and provide a comprehensive overview of the most salient pathophysiologic pathways underlying the links between sleep, sleep disorders, and cardiometabolic functioning.

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Section: Obstructive Sleep Apnea and Cardiometabolic Riskmentioning

confidence: 99%

Section: Obstructive Sleep Apnea and Cardiometabolic Riskmentioning

confidence: 99%

Role of sleep quality in the metabolic syndrome

Koren¹,

Dumin²,

Gozal³

2016

DMSO

152

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“…The overgrown Ad and Tn can induce a developmental disorder in the craniofacial region by obstructing the upper airway and changing respiratory conditions 6 , 7 . It has also been reported that adeno-tonsillar hypertrophy can affect growth in height, weight gain, and cardiopulmonary function 8 , 9 . Recently, it has been shown that adeno-tonsillar hypertrophy is the most common cause of obstructive sleep apnoea (OSA) in children; similarly adeno-tonsillar hypertrophy in adults is one of the reasons of sleep-disordered breathing (SDB), featuring obstructive hypoventilation, snoring, and upper airway narrowing 8 .…”

Section: Introductionmentioning

confidence: 99%

“…It has also been reported that adeno-tonsillar hypertrophy can affect growth in height, weight gain, and cardiopulmonary function 8 , 9 . Recently, it has been shown that adeno-tonsillar hypertrophy is the most common cause of obstructive sleep apnoea (OSA) in children; similarly adeno-tonsillar hypertrophy in adults is one of the reasons of sleep-disordered breathing (SDB), featuring obstructive hypoventilation, snoring, and upper airway narrowing 8 . It has been revealed that a qualitative evaluation of adeno-tonsillar hypertrophy is insufficient for evaluation of the severity of SDB 6 , 10 .…”

Section: Introductionmentioning

confidence: 99%

Differential changes in the adenoids and tonsils in Japanese children and teenagers: a cross-sectional study

Manabe

Ishida

Yoon³

et al. 2017

Sci Rep

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When adenoids (Ad) and tonsils (Tn) become hypertrophied, craniofacial and general body growth is affected. However, there are no objective explicit criteria for evaluating the size of the Ad and Tn, and their respective growth patterns remain unclear. This study determined the average proportions of the Ad and Tn sizes to the upper airway area at various developmental stages in Japanese individuals. Lateral cephalometric radiographs were obtained from 300 Japanese children and teenagers (150 boys and 150 girls, aged 6–20 years), and the respective proportions of Ad to the nasopharynx (Ad/Np) and Tn to the oropharynx (Tn/Op) in the upper airway were determined. Average and standard deviation (SD) were calculated for each of the 5 age groups: lower primary school, upper primary school, junior high school, senior high school, and young adults. We investigated the correlation between age and growth patterns of Ad and Tn, and determined the average Ad/Np and Tn/Op. There was an age-related decrease in Ad and Tn size, and a significant positive correlation between Ad/Np and Tn/Op values in the upper primary school group. Both Ad/Np and Tn/Op decrease as individuals approach adulthood. However, the growth patterns of the Ad/Np and Tn/Op differ from each other.

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“…Leptin has a significant role in food consumption and energy balance regulation (14) as it reduces appetite and increases energy consumption (15). Body mass index (BMI) is significantly correlated with leptin, insulin, and IGF-1 levels (15)(16)(17)(18)(19).…”

Section: Introductionmentioning

confidence: 99%

Effects of methylphenidate on appetite and growth in children diagnosed with attention deficit and hyperactivity disorder

Gürbüz

Çelik

et al. 2016

Journal of Pediatric Endocrinology and Metabolism

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The purpose of this study was to determine the levels of leptin, ghrelin, and nesfatin-1 to elucidate the causes of poor appetite and growth retardation in patients receiving methylphenidate therapy for attention deficit hyperactivity disorder. The study was performed on 89 male subjects; 48 patients and 41 healthy controls, aged 7-14 years. Following treatment, patients' leptin levels increased and ghrelin levels decreased while no significant change was found in nesfatin-1 levels. Of the 48 patients, 34 developed lack of appetite. In patients who developed lack of appetite, body weight SDS, body mass index (BMI), and BMI SDS were statistically significantly reduced; moreover, height SDS was reduced, though not to a statistically significant extent. This study attempted to elucidate the mechanisms that mediate the association between methylphenidate and appetite and growth, for which no studies have yet to be published.

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The effect of adenotonsilectomy on ghrelin, leptin, IGF-1 levels and growth parameters in children with adenotonsillar hypertrophy

Cited by 11 publications

References 7 publications

Role of sleep quality in the metabolic syndrome

Role of sleep quality in the metabolic syndrome

Differential changes in the adenoids and tonsils in Japanese children and teenagers: a cross-sectional study

Effects of methylphenidate on appetite and growth in children diagnosed with attention deficit and hyperactivity disorder

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