The Effect of Adrenal Cortex Hormonal Therapy on Experimental Brucella Uveitis*

Wood, R. M.; Becker, Bernard; Woods, Alan C.

doi:10.1016/0002-9394(53)91883-2

Cited by 7 publications

(2 citation statements)

References 5 publications

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“…Thus, host–pathogen interactions in brucellosis that lead to the development of ocular uveitis can currently be explained by the following two postulated mechanisms. 122 , 123 Brucellae directly invade ocular tissue, via blood or lymphatic tissue circulation, and produce septic emboli in the uveal tissue, resulting in focal chorioretinitis. Immune responses to Brucella infection lead to deposition of immunoglobulins and circulating immune complexes in the uveal tissue, producing an exaggerated autoimmune response.…”

Section: Resultsmentioning

confidence: 99%

“…Thus, host-pathogen interactions in brucellosis that lead to the development of ocular uveitis can currently be explained by the following two postulated mechanisms. 122,123 1. Brucellae directly invade ocular tissue, via blood or lymphatic tissue circulation, and produce septic emboli in the uveal tissue, resulting in focal chorioretinitis.…”

Section: Pathogenesis and Clinical Manifestations Of Uveitismentioning

confidence: 99%

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Ocular Lesions in Brucella Infection: A Review of the Literature

et al. 2022

IDR

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Ocular lesions due to Brucella infection are uncommon and easily overlooked in clinical management, but must be differentiated from non-infectious eye diseases and treated promptly to protect the patient's vision. We reviewed the relevant literature and identified 47 patients with ocular complications of Brucella infection. Among them, 28 showed ocular neuropathy, 15 presented with uveitis, and four patients displayed other ocular symptoms. Ocular symptoms accompanying Brucella infection require prompt diagnosis and treatment. The main methods of diagnosis are intraocular fluid tests and blood tests. Early diagnosis and treatment with suitable antibiotics are central to protecting the patient's vision. Notably, in terms of mechanism of injury, Brucella infection is chronic and cannot be eliminated by phagocytes, and can cause damage to the eye by inducing autoimmune reactions, antigen-antibody complex production, release of endogenous and exogenous toxins, and bacterial production of septic thrombi in the tissues. In this review, we summarize the ocular symptoms, diagnosis, treatment and prognosis of Brucella infection, and discuss the mechanisms of Brucella in ocular lesions, providing a reference for the diagnosis and treatment of Brucella ocular lesions.

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