The effect of adrenergic and cholinergic drugs on methacholine- and histamine-induced bronchoconstriction in monkeys.

Mue, Suetsugu; Ohmi, Toshihito; Suzuki, Shunsuke; Tamura, Gen; Hida, Wataru; Sekizawa, Kiyohisa; Ishihara, Toshiharu; Yamauchi, Kohei; Takishima, Tamotsu

doi:10.1620/tjem.140.109

Cited by 7 publications

(9 citation statements)

References 21 publications

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“…These results are in full coherence with the results of the author Mue Mue et al [25]. In addition to the bronchodilator effect, author Gosens et al suggest that anticholinergic substances, especially those of extended action like tiotropium bromide, might also reduce the constriction of lung functions [26].…”

Section: Discussionsupporting

confidence: 75%

Adrenergic Agonist and Antagonist Action in Airways of Patients with Bronchial Asthma

Islami¹,

Krasniqi²,

Abdullahu³

2011

J Pulmonar Respirat Med

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In this study, the effect of dopamine as agonist dopaminergic receptor and alpha and beta adrenergic receptor was studied both in vivo. The effect of tolazoline as an antagonist of alpha-2 adrenergic receptor was also studied in patients with bronchial asthma and persons with increased bronchial reactibility. Parameters of the lung function are determined by body plethysmography. Raw and ITGV were registered and SRaw was calculated as well. Aerosolization is done with standard aerosolizing machines -Asema. Results gained in vivo shows that stimulation of alpha adrenergic receptor with dopamine (4 µg and 300 µg) causes significant contraction (p > 0.1) of the smooth bronchial musculature. Whereas, blockage of alpha-2 adrenergic receptor with tolazoline (20 mg by inhalator ways) does not change the bronchimotor tonus significantly (p>0.1) when compared to the stimulation of beta-2 adrenergic receptor with hexoprenaline (2 inh. x 0.2 mg) and blocker of cholinergic receptor -ipratropium (2 inh. x 1 mg). Reaction of the smooth musculature to dopamine suggests that this substance may cause constriction through alpha adrenergic receptors. Reaction may also be intermediated in indirect ways through dopaminergic receptor of the cholinergic transmission, with intracellular inhibition of the creation of cAMP.

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Section: Discussionsupporting

confidence: 75%

Adrenergic Agonist and Antagonist Action in Airways of Patients with Bronchial Asthma

Islami¹,

Krasniqi²,

Abdullahu³

2011

J Pulmonar Respirat Med

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“…It was reported that the intravenous injection of atropine decreased the bronchial susceptibility not only to methacholine, but also histamine in monkeys (Mue et al, 1983). In the present study, the participation of the cholinergic pathway in these drug induced broncho-constriction was shown.…”

Section: Discussionmentioning

confidence: 97%

“…Their body weight ranged from 8.7 to 11.9 kg (9.7 kg as mean). The monkeys were regulated for experiments as in previous reports (Mue et al 1980(Mue et al , 1983.…”

Section: Monkeysmentioning

confidence: 99%

The participation of the subepithelial airway receptor in the bronchoconstriction of monkeys.

Mue

Ishihara

Tamura

et al. 1985

Tohoku J. Exp. Med.

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In order to elucidate the mechanism of the bronchial response of monkeys to constrictive stimuli, the effects of pretreatment with aerosolized lidocaine, atropine, and isoproterenol were studied. Treatment with aerosolized lidocaine and atropine not only extinguished the cough reflex, but also decreased bronchial susceptibility to aerosolized methacholine. Moreover, the pretreatment with lidocaine blocked the histamine challenge, but atropine did not. The aerosolized lidocaine decreased the bronchoconstriction induced with methacholine, but not with histamine. Pretreatment with over 1% of isoproterenol did not extinguish the cough reflex. However, this dose of isoproterenol did suppress an increase in Rrs due to the challenge of both methacholine and histamine. Isoproterenol also decreased the bronchoconstriction due to the previous challenge by both methacholine and histamine. The antagonistic effects of lidocaine, atropine, and isoproterenol on the broncho-constriction of monkeys are discussed in relation to the subepithelial receptor.

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“…Isoprenaline has manifested direct myorelaxant effect following the induction of bronchoconstriction with aerosol therapy with methacholine and histamine. Meantime, atropine has manifested the partial bronchodilator effect only after inhalation of methacholine yet not after the inhalatory therapy with histamine (17). …”

Section: Discussionmentioning

confidence: 99%

Importance of Alpha-adrenergic Receptor Subtypes in Regulating of Airways Tonus at Patients with Bronchial Asthma

et al. 2014

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Background:In this work, effect of Tamsulosin hydrochloride as antagonist of alpha1A and alpha1B- adrenergic receptor and effect of Salbutamol as agonist of beta2- adrenergic receptor in patients with bronchial asthma and increased bronchial reactibility was studied.Methods:Parameters of the lung function are determined by Body plethysmography. Raw and ITGV were registered and specific resistance (SRaw) was also calculated. Tamsulosin was administered in per os way as a preparation in the form of the capsules with a brand name of “Prolosin”, producer: Niche Generics Limited, Hitchin, Herts.Results:Results gained from this research show that blockage of alpha1A and alpha1B- adrenergic receptor with Tamsulosin hydrochloride (0.4 mg and 0.8 mg in per os way) has not changed significantly (p > 0.1) the bronchomotor tonus of tracheobronchial tree in comparison to the inhalation of Salbutamol as agonist of beta2- adrenergic receptor (2 inh. x 0.2 mg), (p < 0.05). Arterial blood pressure showed no significant decrease following the administration of the dose of 0.8 mg Tamsulosin.Conclusion:This suggests that the activity of alpha1A and alpha1B- adrenergic receptor in the smooth musculature is not a primary mechanism which causes reaction in patients with increased bronchial reactibility, in comparison to agonists of beta2 – adrenergic receptor which emphasizes their significant action in the reduction of specific resistance of airways.

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The effect of adrenergic and cholinergic drugs on methacholine- and histamine-induced bronchoconstriction in monkeys.

Cited by 7 publications

References 21 publications

Adrenergic Agonist and Antagonist Action in Airways of Patients with Bronchial Asthma

Adrenergic Agonist and Antagonist Action in Airways of Patients with Bronchial Asthma

The participation of the subepithelial airway receptor in the bronchoconstriction of monkeys.

Importance of Alpha-adrenergic Receptor Subtypes in Regulating of Airways Tonus at Patients with Bronchial Asthma

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