“…These lesions resulted in severe alterations in the wall of the arteries (FIGURE 12), with rupture of the internal elastica; replacement of media with foam cells, lipid and cholesterol; calcification and thickening of the lipid-laden intima. Only under certain circumstances (Rosenfield, 1960;Sobel, 1962;Sobel, 1963) did these lesions lead to occlusion of coronary or cerebral arteries. In one report (Bevans, 1951) the early atherosclerotic lesions were shown to be reversible.…”