The effect of ageing on retinal nerve fibre layer thickness: an evaluation by scanning laser polarimetry with variable corneal compensation

Pozzo, Stefano Da; Iacono, Pierluigi; Marchesan, Roberta; Minutola, Daniela; Ravalico, Giuseppe

doi:10.1111/j.1600-0420.2006.00655.x

Cited by 53 publications

(44 citation statements)

References 24 publications

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“…Our study outcome could have been biased by a wide age range: it has been shown that RNFL thickness, as measured by first-generation SLP, decreases with age, and such finding has been confirmed by a recent study performed by means of VCC-SLP [28]. However, it must be observed that such effect is less pronounced using the last-generation device and, in addition, no relevant differences were found in our study.…”

Section: Discussioncontrasting

confidence: 54%

The Influence of Low to Moderate Myopia on Retinal Nerve Fiber Layer as Assessed by Scanning Laser Polarimetry with Variable Corneal Compensator

Vetrugno

Trabucco²,

Sisto³

et al. 2007

Ophthalmologica

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Purpose: To evaluate the influence of different degrees of myopia on retinal nerve fiber layer (RNFL) as measured by scanning laser polarimetry (SLP) with variable corneal compensator (VCC) in healthy eyes. Methods: One hundred and seventy-four healthy age-matched subjects with low to high myopic and emmetropic eyes underwent RNFL measurement by means of GDxVCC. The GDx parameters included in the analysis were: Temporal-superior-nasal-inferior thickness (TSNIT) average, Superior average, Inferior average, TSNIT standard deviation, Inter-eye symmetry, NFI, Symmetry, Superior ratio, Inferior ratio, Superior/nasal, Maximum modulation, Superior maximum, Inferior maximum, Ellipse modulation, Normalized superior area, Normalized inferior area, Ellipse standard deviation, Ellipse average. The mean value of each SLP parameter of myopic eyes was compared with the mean value of the same parameter of emmetropic eyes. Results: Mean myopia was 3.9 ± 1.5 dpt (range: –2 to –8.25 dpt). TNSIT average was higher in myopic group (p = 0.0111), together with Superior average (p = 0.0244), Symmetry (p < 0.0001) and Ellipse average (p = 0.0111). Two ratio parameters, Superior ratio and Inferior ratio, were higher in emmetropic eyes (p = 0.0179 in both cases). In both the myopic and the emmetropic group, all the SLP assessments of the RNFL fell within the normal range, according to the GDx database. Conclusions: Low to high myopia is not related to clinically relevant variations of SLP parameters, as assessed with GDx-VCC.

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Section: Discussioncontrasting

confidence: 54%

The Influence of Low to Moderate Myopia on Retinal Nerve Fiber Layer as Assessed by Scanning Laser Polarimetry with Variable Corneal Compensator

Vetrugno

Trabucco²,

Sisto³

et al. 2007

Ophthalmologica

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“…Crosssectional studies of RNFL thickness using scanning laser polarimetry also have found a decrease in RNFL thickness with age. [9][10][11][12] The human RNFL loses approximately 5000 axons per year from birth to death, approximately 2500 per year before age 50 and 7500 per year after 50. 3 It is not surprising, then, that RNFL thickness decreases with age.…”

Section: Discussionmentioning

confidence: 99%

Determinants of Normal Retinal Nerve Fiber Layer Thickness Measured by Stratus OCT

et al. 2007

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Purpose-To determine the effects of age, optic disc area, ethnicity, eye, gender, and axial length on the retinal nerve fiber layer (RNFL) in the normal human eye as measured by Stratus OCT (optical coherence tomography).Design-Cross-sectional observational study.Participants-Three hundred twenty-eight normal subjects 18 to 85 years old. Methods-PeripapillaryFast RNFL scans performed by Stratus OCT with a nominal diameter of 3.46 mm centered on the optic disc were performed on one randomly selected eye of each subject.Main Outcome Measures-Linear regression analysis of the effects of age, ethnicity, gender, eye, axial length, and optic disc area on peripapillary RNFL thickness.Results-The mean RNFL thickness for the entire population was 100.1 μm (standard deviation, 11.6). Thinner RNFL measurements were associated with older age (P<0.001); being Caucasian, versus being either Hispanic or Asian (P = 0.006); greater axial length (P<0.001); or smaller optic disc area (P = 0.010). For every decade of increased age, mean RNFL thickness measured thinner by approximately 2.0 μm (95% confidence interval [CI], 1.2-2.8). For every 1-mm-greater axial length, mean RNFL thickness measured thinner by approximately 2.2 μm (95% CI, 1.1-3.4). For every increase in square millimeter of optic disc area, mean RNFL thickness increased by approximately 3.3 μm (95% CI, 0.6-5.6). Comparisons between ethnic groups revealed that Caucasians had mean RNFL values (98.1±10.9 μm) slightly thinner than those of Hispanics (103.7±11.6 μm; P = 0.022) or Asians (105.8±9.2 μm; P = 0.043). There was no relationship between RNFL thickness and eye or gender.Correspondence to Donald L. Budenz, MD, MPH, Bascom Palmer Eye Institute, 900 NW 17th Street, Miami, FL 33136. dbudenz@med.miami.edu. Dr Schuman is currently at the Department of Ophthalmology, University of Pittsburgh School of Medicine, Pittsburgh, Pennsylvania. Dr Schuman is a co-patent holder of the optical coherence tomography technology. Dr Patella is an employee of Carl Zeiss Meditec. Dr Quigley is a consultant for Carl Zeiss Meditec. NIH Public Access Author ManuscriptOphthalmology. Author manuscript; available in PMC 2010 August 5. Conclusions-Retinal nerve fiber layer thickness, as measured by Stratus OCT, varies significantly with age, ethnicity, axial length, and optic disc area. These variables may need to be taken into account when evaluating patients for diagnosis and follow-up of glaucoma, particularly at the lower boundary of the normal range. Due to the relatively small numbers of subjects of Asian and African descent in the normative database, conclusions regarding the effect of ethnicity should be interpreted with caution.Glaucoma is an optic neuropathy associated with accelerated apoptosis of retinal ganglion cells (RGCs) that manifests as increased cupping of the optic disc and thinning of the retinal nerve fiber layer (RNFL). The diagnosis of glaucoma is currently based on the appearance of the optic disc, RNFL, and standard achromatic perimetry. 1 The optic disc is ...

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“…They reported an average loss of RNFL thickness of À0.70 mm/year in glaucoma progressors (based on GPA software for standard automated perimetry (SAP)) vs À0.14 mm/year in non-progressors (Po0.001), very similar to rates of change reported elsewhere by the same group (À0.65 and À0.11 mm/year, respectively). 15 Da Pozzo et al, 56 in a cross-sectional design estimated the age-related loss of RNFL thickness in 384 healthy adults and found a rate of À0.08 mm/year attributed to ageing.…”

Section: Cslomentioning

confidence: 99%

Assessment of rates of structural change in glaucoma using imaging technologies

Mansouri

Leite

Medeiros

et al. 2011

Eye

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Purpose To review the ability of current imaging technologies to provide estimates of rates of structural change in glaucoma patients.Patients and methods Review of literature. Results Imaging technologies, such as confocal scanning laser ophthalmoscopy (CSLO), scanning laser polarimetry (SLP), and optical coherence tomography (OCT), provide quantifiable and reproducible measurements of the optic disc and parapapillary retinal nerve fibre layer (RNFL). Rates of change as quantified by the rim area (RA) (for CSLO) and RNFL thickness (for SLP and OCT) are related to glaucoma progression as detected by conventional methods (eg, visual fields and optic disc photography). Evidence shows that rates of RNFL and RA loss are significantly faster in progressing compared with nonprogressing glaucoma patients. Conclusion Measurements of rates of optic disc and RNFL change are becoming increasingly precise and individualized. Currently available imaging technologies have the ability to detect and quantify progression in glaucoma, and their measurements may be suitable end points in glaucoma clinical trials.

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The effect of ageing on retinal nerve fibre layer thickness: an evaluation by scanning laser polarimetry with variable corneal compensation

Cited by 53 publications

References 24 publications

The Influence of Low to Moderate Myopia on Retinal Nerve Fiber Layer as Assessed by Scanning Laser Polarimetry with Variable Corneal Compensator

The Influence of Low to Moderate Myopia on Retinal Nerve Fiber Layer as Assessed by Scanning Laser Polarimetry with Variable Corneal Compensator

Determinants of Normal Retinal Nerve Fiber Layer Thickness Measured by Stratus OCT

Assessment of rates of structural change in glaucoma using imaging technologies

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