The effect of AGTR1, AGТ, LPL, ADRB2 gene polymorphisms on central obesity in adolescents of the Kazakh population

Abstract

BACKGROUND: Abdominal obesity, usually measured by waist circumference and waist-to-hip ratio, is more closely related to metabolic dysfunctions that are associated with cardiovascular diseases than general obesity, which is usually assessed by body mass index. The purpose of our study was to study the distribution of alleles and genotypes AGTR1, AGТ, LPL and ADRB2 among adolescents of the Kazakh population and to identify the relationship of these genes with predictors of obesity. METHODS: The study involved 184 adolescents aged 15-18 years of the Kazakh population. RESULTS: As a result of the study, it was revealed that the G allele of the rs328 polymorphism of the LPL gene reduces the risk of developing abdominal obesity compared to the C allele.The C/G genotype reduces the risk of developing abdominal obesity. We have identifi ed among the studied adolescents of the Kazakh population an increase in the ratio of waist volume (WV) to hip volume (HV) among boys, which may in the future lead to obesity and cardiovascular diseases in general. CONCLUSION: It was also found that the G allele of the rs328 polymorphism of the LPL gene reduces the risk of abdominal obesity. Therefore, in addition to determining BMI, we recommend determining the ratio WV to HP. It was found that an increase in the ratio of WV/HV by 1 cm increases the chance of developing hypoapolipoproteinemia A1 (Tab. 4, Fig. 1, Ref. 23).

Identification of novel prognostic targets in acute kidney injury using bioinformatics and next generation sequencing data analysis

“…PLG (plasminogen) [81] plays an indispensable role in glomerulonephritis. AFM (afamin) [82], AGTR1 [83] and IL1RL1 [84] could be an early detection biomarkers for obesity. AGTR1 [85] and UMOD (uromodulin) [86] expression is a potential target for diabetic nephropathy.…”

“…E2F1 [496], AGTR1 [74], VCAM1 [533], hsa-mir-7847-3p [804], FOXC1 [805], USF2 [796], YY1 [806], STAT3 [807] and BRCA1 [799] have been observed in sepsis patients. Studies have shown that E2F1 [669], VCAM1 [715], AGTR1 [83], hsa-mir-221 [780], YY1 [808], STAT3 [809], PDX1 [810] and BRCA1 [811] are associated with obesity. E2F1 [719] and VCAM1 [736] are altered expressed in patients with renal ischemia.…”

The content of adipokines and myokines in the blood of children and adolescents with different genotypes according to the polymorphism rs662 of the paraoxonase-1 gene

“…Среди многочисленных причин ожирения особое место занимают генетические факторы. К настоящему времени установлено более 100 генов, которые связаны с ожирением [5][6][7]. Очевидная роль среди них принадлежит генетическому полиморфизму ферментов, участвующих в метаболизме липидов, к числу которых относятся печеночная триацилглицероллипаза и липопротеинлипаза, а также параоксоназа-1 (PON-1) имеющие тканеспецифическую локализацию в организме [6,[8][9][10][11].…”

The Association of Adipokines and Myokines in the Blood of Obese Children and Adolescents with Lipoprotein Lipase rs328 Gene Variants

“…Tis isoform alters the blood levels of TAG, cholesterol, and HDLs; however, the data on these shifts are controversial [2,[11][12][13][14]. On the one hand, 447Ter is associated with the reduced risk of abdominal obesity [15], while on the other hand, carriers of the 447Ter genotype sufer from cardiovascular diseases more frequently [16].…”