The Effect of Alcoholic Extract of Cyperus rotundus on Acute Inflammatory in Male Mice

Abstract

Introduction:The anti-inflammatory drugs are associated with some side effects. The herbal medicine has fewer side effects. In the present study, the anti-inflammatory effects of the alcoholic extract of Cyperus rotundus were investigated on acute inflammation in male mice. Methods: In this experimental study, 30 mice were randomly assigned into 5 groups of 6, including the solvent group (physiological serum), the control group (carrageenan only), 2 groups of 100 and 300 mg/kg extract, and the last group received ibuprofen. Inflammation in mice with subcutaneous injection of 0.25 ml of 0.5% solution of carrageenan was created into the animal's foot. Results:The results of this study showed that the mean of changes in inflammation was significant among the groups (P < 0.001). The process of inflammatory changes in all tested groups was initially increased and its maximum value was 2 hours after injection. Then, the process of reduction of inflammation started at the same time reducing the inflammation in the treatment groups with extract significantly compared to the negative and positive control groups It happened faster (P ≤ 0.01). Conclusions: The present study showed that Cyperus rotundus extract has significant anti-inflammatory effects; however, additional researches are needed to understand the possible mechanism of this effect.